New Insights into the Immune System Using Dirty Mice

Healthy Human Gastrointestinal Microbiome: Composition and Function After a Decade of Exploration

(2020) Wenly Ruan et al.   DIGESTIVE DISEASES AND SCIENCES

Cutting Edge: Antitumor Immunity by Pathogen-Specific CD8 T Cells in the Absence of Cognate Antigen Recognition

(2020) Derek B. Danahy et al.   JOURNAL OF IMMUNOLOGY

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

(2020) Rachel Thomas et al.   Immunity & Ageing

Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

(2020) Frank Yeung et al.   Cell Host & Microbe

Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

(2020) Jian-Da Lin et al.   Cell Host & Microbe

Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross

(2020) Matthew D. Martin et al.   Cell Reports

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

(2019) Pamela C. Rosato et al.   Nature Communications

Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival

(2019) Derek B. Danahy et al.   JOURNAL OF IMMUNOLOGY

Mouse Vendor Influence on the Bacterial and Viral Gut Composition Exceeds the Effect of Diet

(2019) Torben Sølbeck Rasmussen et al.   Viruses-Basel

Comparison of Co-housing and Littermate Methods for Microbiota Standardization in Mouse Models

(2019) Susan J. Robertson et al.   Cell Reports

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Laboratory mice born to wild mice have natural microbiota and model human immune responses

(2019) Stephan P. Rosshart et al.   SCIENCE

The Fluctuations of Leukocytes and Circulating Cytokines in Septic Humanized Mice Vary With Outcome

(2019) Tomasz Skirecki et al.   Frontiers in Immunology

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

(2019) Simone L. Park et al.   TRENDS IN IMMUNOLOGY

Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization

(2019) Matthew A. Huggins et al.   Cell Reports

Targeting senescent cells in translational medicine

(2019) Marta Paez‐Ribes et al.   EMBO Molecular Medicine

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Immune Training Unlocks Innate Potential

(2018) Wilbur M. Song et al.   CELL

The hygiene hypothesis: immunological mechanisms of airway tolerance

(2018) Eline Haspeslagh et al.   CURRENT OPINION IN IMMUNOLOGY

Tissue-resident memory T cells at the center of immunity to solid tumors

(2018) Derk Amsen et al.   NATURE IMMUNOLOGY

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

Regulators of Intestinal Epithelial Migration in Sepsis

(2018) Mei Meng et al.   SHOCK

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Rapid environmental effects on gut nematode susceptibility in rewilded mice

(2018) Jacqueline M. Leung et al.   PLOS BIOLOGY

Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis?

(2018) Yuan Chao Xue et al.   Frontiers in Molecular Neuroscience

Embracing microbial exposure in mouse research

(2018) Mathew A. Huggins et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Virtual memory CD8 T cells expanded by helminth infection confer broad protection against bacterial infection

(2018) J. S. Lin et al.   Mucosal Immunology

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

(2018) Wouter Scheper et al.   NATURE MEDICINE

Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection

(2018) Marion Rolot et al.   Nature Communications

Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections

(2018) Isaac J. Jensen et al.   PLoS Pathogens

Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses

(2018) Frances V. Sjaastad et al.   Frontiers in Immunology

Murine Models of Sepsis and Trauma: Can We Bridge the Gap?

(2017) Julie A. Stortz et al.   ILAR JOURNAL

Targeting Immune Cell Checkpoints during Sepsis

(2017) Naeem Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology

(2017) David Masopust et al.   JOURNAL OF IMMUNOLOGY

Virus-Specific CD8+T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression

(2017) Dan A. Erkes et al.   JOURNAL OF IMMUNOLOGY

Heterogeneity of Rotavirus Vaccine Efficacy Among Infants in Developing Countries

(2017) Joann F. Gruber et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice

(2017) Krzysztof Laudanski et al.   PLoS One

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells

(2017) Derek B. Danahy et al.   PLoS Pathogens

Long-term Monocyte Dysfunction after Sepsis in Humanized Mice Is Related to Persisted Activation of Macrophage-Colony Stimulation Factor (M-CSF) and Demethylation of PU.1, and It Can Be Reversed by Blocking M-CSF In Vitro or by Transplanting Naïve Autologous Stem Cells In Vivo

(2017) Natalia Lapko et al.   Frontiers in Immunology

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

(2016) Tiffany A. Reese et al.   Cell Host & Microbe

Wild immunology assessed by multidimensional mass cytometry

(2016) Alberto Sada Japp et al.   CYTOMETRY PART A

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

(2016) Manu Shankar-Hari et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis

(2016) Javier Cabrera-Perez et al.   JOURNAL OF IMMUNOLOGY

Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo

(2016) Robert K. Strother et al.   JOURNAL OF IMMUNOLOGY

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Composition of the gut microbiota modulates the severity of malaria

(2016) Nicolas F. Villarino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+T Cell Exhaustion

(2015) Stephanie A. Condotta et al.   JOURNAL OF IMMUNOLOGY

Alterations in Antigen-Specific Naive CD4 T Cell Precursors after Sepsis Impairs Their Responsiveness to Pathogen Challenge

(2015) Javier Cabrera-Perez et al.   JOURNAL OF IMMUNOLOGY

Sepsis: a roadmap for future research

(2015) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

(2015) Cornelia Lindner et al.   NATURE IMMUNOLOGY

Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model

(2015) Tomasz Skirecki et al.   Stem Cell Research & Therapy

Aging of the human innate immune system in HIV infection

(2014) Heidi J Zapata et al.   CURRENT OPINION IN IMMUNOLOGY

Bystander Chronic Infection Negatively Impacts Development of CD8+ T Cell Memory

(2014) Erietta Stelekati et al.   IMMUNITY

Polymicrobial Sepsis Alters Antigen-Dependent and -Independent Memory CD8 T Cell Functions

(2014) S. Duong et al.   JOURNAL OF IMMUNOLOGY

Immunopathogenesis of abdominal sepsis

(2014) Georg F. Weber et al.   LANGENBECKS ARCHIVES OF SURGERY

Engagement of NKG2D on Bystander Memory CD8 T Cells Promotes Increased Immunopathology following Leishmania major Infection

(2014) Erika J. Crosby et al.   PLoS Pathogens

Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit

(2014) Jean-Louis Vincent et al.   Lancet Respiratory Medicine

Overcoming Current Limitations in Humanized Mouse Research

(2013) Michael A. Brehm et al.   JOURNAL OF INFECTIOUS DISEASES

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View

(2013) Wibke Schulte et al.   MEDIATORS OF INFLAMMATION

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner

(2013) Talyn Chu et al.   Cell Reports

Chronic Bystander Infections and Immunity to Unrelated Antigens

(2012) Erietta Stelekati et al.   Cell Host & Microbe

Infectious Agents and Neurodegeneration

(2012) Giovanna De Chiara et al.   MOLECULAR NEUROBIOLOGY

Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model

(2012) C. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Immune Unresponsiveness to Secondary Heterologous Bacterial Infection after Sepsis Induction Is TRAIL Dependent

(2011) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

HIV infection and aging of the innate immune system

(2011) Anna C. Hearps et al.   Sexual Health

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Sepsis-induced human lymphocyte apoptosis and cytokine production in “humanized” mice

(2009) Jacqueline Unsinger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Bacterial Community Variation in Human Body Habitats Across Space and Time

(2009) E. K. Costello et al.   SCIENCE