The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

NLRP3 recruitment by NLRC4 duringSalmonellainfection

(2016) Yan Qu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis

(2016) Prajwal Gurung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

(2016) Seth L. Masters et al.   Science Translational Medicine

Mitochondrial damage contributes toPseudomonas aeruginosaactivation of the inflammasome and is downregulated by autophagy

(2015) Majid Sakhi Jabir et al.   Autophagy

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

(2015) Roni Nowarski et al.   CELL

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

(2015) Rajendra Karki et al.   Cell Host & Microbe

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish

(2015) William J.B. Vincent et al.   CELLULAR MICROBIOLOGY

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells

(2015) John R. Lukens et al.   IMMUNITY

CARD- and pyrin-only proteins regulating inflammasome activation and immunity

(2015) Magdalena Matusiak et al.   IMMUNOLOGICAL REVIEWS

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin

(2015) Jens Kortmann et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

(2015) Etienne Meunier et al.   NATURE IMMUNOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

(2015) Pervinder Sagoo et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

(2015) Lorenzo Sborgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nlrp6 regulates intestinal antiviral innate immunity

(2015) Penghua Wang et al.   SCIENCE

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation

(2015) Christoph A. Diebolder et al.   STRUCTURE

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Caspase-1 Cleavage of the TLR Adaptor TRIF Inhibits Autophagy and β-Interferon Production during Pseudomonas aeruginosa Infection

(2014) Majid Sakhi Jabir et al.   Cell Host & Microbe

An inherited mutation inNLRC4causes autoinflammation in human and mice

(2014) Akiko Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

(2014) Jeannette L. Tenthorey et al.   MOLECULAR CELL

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(2014) Susanne Dihlmann et al.   MOLECULAR MEDICINE

Dietary modulation of the microbiome affects autoinflammatory disease

(2014) John R. Lukens et al.   NATURE

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

(2014) Neil Romberg et al.   NATURE GENETICS

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

(2014) Sonal Khare et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Actin polymerization as a key innate immune effector mechanism to controlSalmonellainfection

(2014) Si Ming Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function

(2014) Baptiste Guey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response

(2014) Ting Liu et al.   Cell Reports

The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis

(2014) Aline Dumas et al.   PLoS Pathogens

A Highly Conserved Toxo1 Haplotype Directs Resistance to Toxoplasmosis and Its Associated Caspase-1 Dependent Killing of Parasite and Host Macrophage

(2014) Pierre Cavailles et al.   PLoS Pathogens

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

(2014) Marco A. Ataide et al.   PLoS Pathogens

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

(2014) Kimberly M. Cirelli et al.   PLoS Pathogens

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation

(2013) Y-H Wu et al.   CELL DEATH AND DIFFERENTIATION

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly

(2013) Tengchuan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Mycobacterium tuberculosis but Not Nonvirulent Mycobacteria Inhibits IFN-  and AIM2 Inflammasome-Dependent IL-1  Production via Its ESX-1 Secretion System

(2013) S. Shah et al.   JOURNAL OF IMMUNOLOGY

Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1  Production

(2013) S. M. Man et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein

(2013) M. Rayamajhi et al.   JOURNAL OF IMMUNOLOGY

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

(2013) Larissa Ponomareva et al.   MOLECULAR CANCER RESEARCH

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

(2013) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

(2013) M. H. Zaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1

(2013) Tengchuan Jin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

(2013) Qian Yin et al.   Cell Reports

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling

(2013) He Li et al.   Acta Crystallographica Section F-Structural Biology Communications

The CARD plays a critical role in ASC foci formation and inflammasome signalling

(2012) Martina Proell et al.   BIOCHEMICAL JOURNAL

The mammalian PYHIN gene family: Phylogeny, evolution and expression

(2012) Jasmyn A Cridland et al.   BMC EVOLUTIONARY BIOLOGY

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

(2012) Vincent Compan et al.   IMMUNITY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

(2012) Seth L. Masters et al.   IMMUNITY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility

(2012) Divaker Choubey   IMMUNOLOGY LETTERS

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

(2012) Joshua N. Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion

(2012) C. Peral de Castro et al.   JOURNAL OF IMMUNOLOGY

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

(2012) Jakob von Moltke et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking

(2012) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity

(2012) Bradley C. Frew et al.   PLoS Pathogens

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis

(2011) Kaitian Peng et al.   CELLULAR MICROBIOLOGY

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1

(2011) N. Jounai et al.   JOURNAL OF IMMUNOLOGY

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands

(2011) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

(2010) Sarah Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A coding variant in NLRP1 is associated with autoimmune Addison's disease

(2010) Magdalena Żurawek et al.   HUMAN IMMUNOLOGY

NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate ofToxoplasma gondii-Infected Monocytic Cells

(2010) William H. Witola et al.   INFECTION AND IMMUNITY

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Anthrax Lethal Toxin Triggers the Formation of a Membrane-Associated Inflammasome Complex in Murine Macrophages

(2009) A. M. Nour et al.   INFECTION AND IMMUNITY

Kinetic properties of ASC protein aggregation in epithelial cells

(2009) Jun Cheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

(2009) L. O'Regan et al.   MOLECULAR AND CELLULAR BIOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE