Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers

(2015) Silvia Federici et al.   ANNALS OF THE RHEUMATIC DISEASES

GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles

(2015) Agne Antanaviciute et al.   BIOINFORMATICS

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β

(2015) Man Lyang Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

14-3-3 Proteins in Plant-Pathogen Interactions

(2015) Rosa Lozano-Durán et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Sweet's Syndrome in Patients with MDS and MEFV Mutations

(2015) Tatsuro Jo et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Plant Phosphoswitch Platform Repeatedly Targeted by Type III Effector Proteins Regulates the Output of Both Tiers of Plant Immune Receptors

(2014) Eui-Hwan Chung et al.   Cell Host & Microbe

A Novel Flow Cytometric Method To Assess Inflammasome Formation

(2014) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification

(2014) Pitter F Huesgen et al.   NATURE METHODS

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEFVmutations affecting pyrin amino acid 577 cause autosomal dominant autoinflammatory disease

(2013) Monique Stoffels et al.   ANNALS OF THE RHEUMATIC DISEASES

Specific Threonine Phosphorylation of a Host Target by Two Unrelated Type III Effectors Activates a Host Innate Immune Receptor in Plants

(2011) Eui-Hwan Chung et al.   Cell Host & Microbe

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin

(2008) Helmut Wittkowski et al.   ARTHRITIS AND RHEUMATISM

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF- B through its N-terminal fragment

(2008) J. J. Chae et al.   BLOOD

Pyrin and ASC Co-Localize to Cellular Sites that Are Rich in Polymerizing Actin

(2008) Andrea L. Waite et al.   EXPERIMENTAL BIOLOGY AND MEDICINE