Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection

(2013) Pierre Guermonprez et al.   NATURE MEDICINE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Clinical Profile of Concurrent Dengue Fever and Plasmodium vivax Malaria in the Brazilian Amazon: Case Series of 11 Hospitalized Patients

(2012) Belisa M. L. Magalhães et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Postmortem Characterization of Patients With Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent Does This Parasite Kill?

(2012) Marcus V. G. Lacerda et al.   CLINICAL INFECTIOUS DISEASES

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

Global malaria mortality between 1980 and 2010: a systematic analysis

(2012) Christopher JL Murray et al.   LANCET

Pathogen sensors and chemokine receptors in dendritic cell subsets

(2012) Tsuneyasu Kaisho   VACCINE

Neutrophil Paralysis in Plasmodium vivax Malaria

(2012) Fabiana Maria de Souza Leoratti et al.   PLoS Neglected Tropical Diseases

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Identification and functional consequences of a recurrent NLRP12 missense mutation in periodic fever syndromes

(2011) Isabelle Jéru et al.   ARTHRITIS AND RHEUMATISM

Role of interleukin-1β in NLRP12-associated autoinflammatory disorders and resistance to anti-interleukin-1 therapy

(2011) Isabelle Jéru et al.   ARTHRITIS AND RHEUMATISM

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

(2011) Shruti Sharma et al.   IMMUNITY

Caspase-1 Activation of Interleukin-1β (IL-1β) and IL-18 Is Dispensable for Induction of Experimental Cerebral Malaria

(2011) Maximilian Kordes et al.   INFECTION AND IMMUNITY

Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study

(2011) J Anthony G Scott et al.   LANCET

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Malaria impairs resistance to Salmonella through heme- and heme oxygenase–dependent dysfunctional granulocyte mobilization

(2011) Aubrey J Cunnington et al.   NATURE MEDICINE

Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria

(2011) Bernardo S. Franklin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR9 Polymorphisms Are Associated with Altered IFN-γ Levels in Children with Cerebral Malaria

(2010) Nadia A. Sam-Agudu et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Tumour necrosis factor-dependent parasite-killing effects during paroxysms in non-immune Plasmodium vivax malaria patients

(2010) N. D. KARUNAWEERA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Bacteremia in Kenyan Children Presenting with Malaria

(2010) T. Were et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-12 Dampens the Immune Response to Malaria Independently of the Inflammasome by Targeting NF- B Signaling

(2010) K. Labbe et al.   JOURNAL OF IMMUNOLOGY

Protein-DNA Complex Is the Exclusive Malaria Parasite Component That Activates Dendritic Cells and Triggers Innate Immune Responses

(2010) X. Wu et al.   JOURNAL OF IMMUNOLOGY

Interaction of Saccharomyces boulardii with Salmonella enterica Serovar Typhimurium Protects Mice and Modifies T84 Cell Response to the Infection

(2010) Flaviano S. Martins et al.   PLoS One

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

(2009) Thornik Reimer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Pure Hemozoin Is Inflammatory In Vivo and Activates the NALP3 Inflammasome via Release of Uric Acid

(2009) J. W. Griffith et al.   JOURNAL OF IMMUNOLOGY

Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite

(2009) Ivo Mueller et al.   LANCET INFECTIOUS DISEASES

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Malaria primes the innate immune response due to interferon-  induced enhancement of toll-like receptor expression and function

(2009) B. S. Franklin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Enhanced Toll-Like Receptor Responsiveness Associated with Mitogen-Activated Protein Kinase Activation in Plasmodium falciparum-Infected Children

(2008) F. C. Hartgers et al.   INFECTION AND IMMUNITY

Alterations of Splenic Architecture in Malaria Are Induced Independently of Toll-Like Receptors 2, 4, and 9 or MyD88 and May Affect Antibody Affinity

(2008) E. T. Cadman et al.   INFECTION AND IMMUNITY

Variants in the Toll‐Like Receptor Signaling Pathway and Clinical Outcomes of Malaria

(2008) Fabiana M. S. Leoratti et al.   JOURNAL OF INFECTIOUS DISEASES

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

ATP-gated P2X cation-channels

(2008) Michael F. Jarvis et al.   NEUROPHARMACOLOGY