Current Understanding of the Pivotal Role of Mitochondrial Dynamics in Cardiovascular Diseases and Senescence

Irisin alleviates vascular calcification by inhibiting VSMC osteoblastic transformation and mitochondria dysfunction via AMPK/Drp1 signaling pathway in chronic kidney disease

(2022) Pei-Wen Wang et al.   ATHEROSCLEROSIS

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

(2021) Yoshikazu Johmura et al.   SCIENCE

The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy

(2021) Mohamed Bekhite et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial protective effects of PARP-inhibition in hypertension-induced myocardial remodeling and in stressed cardiomyocytes

(2021) K. Ordog et al.   LIFE SCIENCES

High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy

(2021) Qing-Rui Wu et al.   Cell Death & Disease

Transcriptomic and Functional Analyses of Mitochondrial Dysfunction in Pressure Overload‐Induced Right Ventricular Failure

(2021) HyunTae V. Hwang et al.   Journal of the American Heart Association

ERK/Drp1‐dependent mitochondrial fission contributes to HMGB1‐induced autophagy in pulmonary arterial hypertension

(2021) Wei Feng et al.   CELL PROLIFERATION

Different characteristics of mitochondrial dynamics-related miRNAs on the hemodynamics of pulmonary artery hypertension and chronic thromboembolic pulmonary hypertension

(2021) Noriko Iwatani et al.   Journal of Cardiology

Cardiac‐specific overexpression of miR‐122 induces mitochondria‐dependent cardiomyocyte apoptosis and promotes heart failure by inhibiting Hand2

(2021) Yajuan Shi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction

(2021) Xiaodong Zhuang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The changing landscape of atherosclerosis

(2021) Peter Libby   NATURE

Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy

(2021) Yung Ting Hsiao et al.   Scientific Reports

Estrogen Plays a Crucial Role in Rab9‐Dependent Mitochondrial Autophagy, Delaying Arterial Senescence

(2021) Yuichi Sasaki et al.   Journal of the American Heart Association

The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamics

(2021) Yuqiong Chen et al.   Redox Biology

Mdivi-1, a mitochondrial fission inhibitor, reduces angiotensin-II- induced hypertension by mediating VSMC phenotypic switch

(2021) Yue Deng et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective role of the mitochondrial fusion protein OPA1 in hypertension

(2021) Pauline Robert et al.   FASEB JOURNAL

PINK1‐induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension

(2021) Asish Dasgupta et al.   FASEB JOURNAL

WNT5B promotes vascular smooth muscle cell dedifferentiation via mitochondrial dynamics regulation in chronic thromboembolic pulmonary hypertension

(2021) Feng Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective Effect of Optic Atrophy 1 on Cardiomyocyte Oxidative Stress: Roles of Mitophagy, Mitochondrial Fission, and MAPK/ERK Signaling

(2021) Yue Wang et al.   Oxidative Medicine and Cellular Longevity

Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension

(2021) Olga Tura-Ceide et al.   Scientific Reports

Nicorandil, an ATP-sensitive potassium channel activation, attenuates myocardial injury in rats with ischemic cardiomyopathy

(2021) Li Shaoqing et al.   Medical Molecular Morphology

Cordycepin Decreases Ischemia/Reperfusion Injury in Diabetic Hearts via Upregulating AMPK/Mfn2-dependent Mitochondrial Fusion

(2021) Houyou Yu et al.   Frontiers in Pharmacology

Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy

(2021) Chaoyang Liu et al.   Redox Biology

Association of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 With Angiotensin II Type 1 Receptor Impacts Mitochondrial Quality Control, Offering Promise for the Treatment of Vascular Senescence

(2021) Yoshihiro Uchikado et al.   Frontiers in Cardiovascular Medicine

Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy

(2020) Yi Zhu et al.   APOPTOSIS

Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction

(2020) Qingxun Hu et al.   CIRCULATION RESEARCH

Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy

(2020) Shawn Yongshun Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

(2020) Ting Xin et al.   Aging-US

Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm

(2020) Hannah A Cooper et al.   CARDIOVASCULAR RESEARCH

Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis

(2020) Lian Tian et al.   CIRCULATION RESEARCH

Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction

(2020) Adam R. Wende et al.   DIABETES

Melatonin attenuates vascular calcification by inhibiting mitochondria fission via an AMPK/Drp1 signalling pathway

(2020) Wei Ren Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism

(2020) Tianqi Xie et al.   Frontiers in Pharmacology

Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6

(2020) Li‐Ming Yu et al.   JOURNAL OF PINEAL RESEARCH

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission

(2020) Dong Ma et al.   PLOS BIOLOGY

Moderate Exercise in Spontaneously Hypertensive Rats Is Unable to Activate the Expression of Genes Linked to Mitochondrial Dynamics and Biogenesis in Cardiomyocytes

(2020) Clara Quiroga et al.   Frontiers in Endocrinology

Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress

(2020) Bing Zhuan et al.   Aging-US

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

(2020) Siavash Beikoghli Kalkhoran et al.   CARDIOVASCULAR RESEARCH

Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy

(2020) Thawatchai Khuanjing et al.   Translational Research

A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats

(2019) Julio C. B. Ferreira et al.   Nature Communications

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration

(2019) Chowdhury S. Abdullah et al.   Scientific Reports

Resveratrol attenuates oxidative injury in human umbilical vein endothelial cells through regulating mitochondrial fusion via TyrRS-PARP1 pathway

(2019) Jining Yang et al.   Nutrition & Metabolism

Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction

(2019) Antoine H. Chaanine et al.   Circulation-Heart Failure

Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy

(2019) Bereketeab Haileselassie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides

(2019) Phung N. Thai et al.   Frontiers in Physiology

Targeting HSP90 attenuates angiotensin II-induced adventitial remodeling via suppression of mitochondrial fission

(2019) Gaojian Huang et al.   CARDIOVASCULAR RESEARCH

Glucagon-Like Peptide-1 Receptor Agonist Attenuates Autophagy to Ameliorate Pulmonary Arterial Hypertension through Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3β Pathways

(2019) Yi-Chia Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases

(2019) Wei Wu et al.   Cell Death & Disease

Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

(2019) Daniel J. Tyrrell et al.   CIRCULATION RESEARCH

Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury

(2019) Ivonne Olmedo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury

(2018) Lei Qin et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats

(2018) Prottoy Hasan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

(2018) Gian-Luca McLelland et al.   eLife

Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor

(2018) Yuxuan Guo et al.   Nature Communications

PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions

(2018) Lu He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin attenuates myocardial ischemia reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways

(2018) Ying Zhang et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial dynamics as an underlying mechanism involved in aerobic exercise training-induced cardioprotection against ischemia-reperfusion injury

(2018) Reza Ghahremani et al.   LIFE SCIENCES

Penehyclidine hydrochloride preconditioning provides cardiac protection in a rat model of myocardial ischemia/reperfusion injury via the mechanism of mitochondrial dynamics mechanism

(2017) Yanli Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial PKC-ε deficiency promotes I/R-mediated myocardial injury via GSK3β-dependent mitochondrial permeability transition pore opening

(2017) Shijun Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling

(2017) Cui Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ferulic acid, a bioactive component of rice bran, improves oxidative stress and mitochondrial biogenesis and dynamics in mice and in human mononuclear cells

(2017) Cristina Perez-Ternero et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission

(2017) Lei Cui et al.   VASCULAR PHARMACOLOGY

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission

(2017) Kensuke Tsushima et al.   CIRCULATION RESEARCH

High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects

(2016) J. Yu et al.   Acta Physiologica

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo

(2016) Scott J. Bultman et al.   CARDIOVASCULAR PATHOLOGY

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Reactive oxygen species effect PASMCs apoptosis via regulation of dynamin-related protein 1 in hypoxic pulmonary hypertension

(2016) Lixin Zhang et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

(2016) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Rg1 prevents myocardial hypoxia/reoxygenation injury by regulating mitochondrial dynamics imbalance via modulation of glutamate dehydrogenase and mitofusin 2

(2016) Gengting Dong et al.   MITOCHONDRION

Remote Ischemic Conditioning Influences Mitochondrial Dynamics

(2016) Laura Cellier et al.   SHOCK

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

(2016) A R Hall et al.   Cell Death & Disease

Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids

(2016) Audrey Swiader et al.   Oncotarget

Increase in Cardiac Ischemia-Reperfusion Injuries in Opa1+/- Mouse Model

(2016) Sophie Le Page et al.   PLoS One

The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons

(2016) Haibin Wang et al.   PLoS One

Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2016) Wenyan Sun et al.   Scientific Reports

Heat shock protein 90 inhibition by 17-DMAG attenuates abdominal aortic aneurysm formation in mice

(2015) Jia Qi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Downregulation of Dynamin-Related Protein 1 Contributes to Impaired Autophagic Flux and Angiogenic Function in Senescent Endothelial Cells

(2015) J.-R. Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA

(2015) Liang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse HeartsNovelty and Significance

(2015) Moshi Song et al.   CIRCULATION RESEARCH

The Critical Role of Dynamin-Related Protein 1 in Hypoxia-Induced Pulmonary Vascular Angiogenesis

(2015) Tingting Shen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of Mitochondrial Morphology by Positive Feedback Interaction Between PKCδ and Drp1 in Vascular Smooth Muscle Cell

(2015) Soyeon Lim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adiponectin affects vascular smooth muscle cell proliferation and apoptosis through modulation of the mitofusin-2-mediated Ras-Raf-Erk1/2 signaling pathway

(2015) WENBO ZHANG et al.   Molecular Medicine Reports

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

(2015) G. Gong et al.   SCIENCE

Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance

(2015) Peng Yu et al.   PLoS One

Dietary supplementation with fish oil alters the expression levels of proteins governing mitochondrial dynamics and prevents high-fat diet-induced endothelial dysfunction

(2014) Ruifang Sun et al.   BRITISH JOURNAL OF NUTRITION

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

The Right Ventricle in Pulmonary Arterial Hypertension

(2014) John J. Ryan et al.   CIRCULATION RESEARCH

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

Roles of mitochondrial fragmentation and reactive oxygen species in mitochondrial dysfunction and myocardial insulin resistance

(2014) Tomoyuki Watanabe et al.   EXPERIMENTAL CELL RESEARCH

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway

(2014) C. Pennanen et al.   JOURNAL OF CELL SCIENCE

Mitofusin 1 Is Negatively Regulated by MicroRNA 140 in Cardiomyocyte Apoptosis

(2014) J. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension

(2013) John J. Ryan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion

(2013) Christelle Kamga Pride et al.   CARDIOVASCULAR RESEARCH

Mitochondrial DNA Damage, Oxidative Stress, and Atherosclerosis

(2013) Sean M. Davidson et al.   CIRCULATION

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

Cardiac Metabolism in Heart Failure

(2013) Torsten Doenst et al.   CIRCULATION RESEARCH

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB–Mediated Inflammation in Macrophages

(2013) Ying Wang et al.   CIRCULATION RESEARCH

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein

(2013) Chris Fröhlich et al.   EMBO JOURNAL

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation

(2013) S. Din et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

OPA1 Mutation and Late‐Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability

(2013) Le Chen et al.   Journal of the American Heart Association

Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation

(2013) Joshua K. Salabei et al.   Redox Biology

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates

(2012) Jian Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk

(2012) Yun Chen et al.   CIRCULATION RESEARCH

Mitofusins 1 and 2 Are Essential for Postnatal Metabolic Remodeling in Heart

(2012) Kyriakos N. Papanicolaou et al.   CIRCULATION RESEARCH

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

(2012) Glenn Marsboom et al.   CIRCULATION RESEARCH

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes

(2012) Ting Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Dynamin-related Protein 1 (DRP1) Function by IncreasedO-linked-β-N-acetylglucosamine Modification (O-GlcNAc) in Cardiac Myocytes

(2012) Thomas Gawlowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valsartan inhibits angiotensin II-induced proliferation of vascular smooth muscle cells via regulating the expression of mitofusin 2

(2012) Hua Liao et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

GSK3beta-Mediated Drp1 Phosphorylation Induced Elongated Mitochondrial Morphology against Oxidative Stress

(2012) Chia-Hua Chou et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

(2011) Youngil Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death

(2011) Kyriakos N. Papanicolaou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes

(2011) Ayako Makino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

(2011) Yun Chen et al.   CIRCULATION RESEARCH

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

(2011) K. N. Papanicolaou et al.   MOLECULAR AND CELLULAR BIOLOGY

The Soluble Form of Bax Regulates Mitochondrial Fusion via MFN2 Homotypic Complexes

(2011) Suzanne Hoppins et al.   MOLECULAR CELL

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

(2011) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Glucose Stimulation Increases Reactive Oxygen Species Production Through the Calcium and Mitogen-Activated Protein Kinase-Mediated Activation of Mitochondrial Fission

(2010) Tianzheng Yu et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes

(2010) Jennifer Hom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Proteomic Approach to Determine Changes in Proteins Involved in the Myocardial Metabolism in Left Ventricles of Spontaneously Hypertensive Rats

(2010) Jose Zamorano-León et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo

(2010) Xin Qi et al.   MOLECULAR BIOLOGY OF THE CELL

miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1

(2010) Jian-Xun Wang et al.   NATURE MEDICINE

Mitochondrial OPA1, apoptosis, and heart failure

(2009) Le Chen et al.   CARDIOVASCULAR RESEARCH

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

(2009) Ethan J. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects

(2008) W-C Cheng et al.   CELL DEATH AND DIFFERENTIATION

Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

(2008) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

(2008) Philippe A. Parone et al.   PLoS One