Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Altered mitochondrial quality control in Atg7-deficient VSMCs promotes enhanced apoptosis and is linked to unstable atherosclerotic plaque phenotype

(2019) Hripsimé Nahapetyan et al.   Cell Death & Disease

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Somatic Mutations and Clonal Hematopoiesis

(2018) José J. Fuster et al.   CIRCULATION RESEARCH

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

(2018) Michelle R. Marasco et al.   DIABETES

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

The regulation of skeletal muscle fatigability and mitochondrial function by chronically elevated interleukin-6

(2018) Brandon N. VanderVeen et al.   EXPERIMENTAL PHYSIOLOGY

Monocyte-Macrophages and T Cells in Atherosclerosis

(2017) Ira Tabas et al.   IMMUNITY

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction

(2017) Paishiun N. Hsieh et al.   Nature Communications

Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice

(2017) Aleksandr E. Vendrov et al.   Journal of the American Heart Association

Age-associated vascular inflammation promotes monocytosis during atherogenesis

(2016) Wei Du et al.   AGING CELL

Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy

(2016) Cédéric F. Michiels et al.   ATHEROSCLEROSIS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Intracellular pH Modulates Autophagy and Mitophagy

(2016) Alexey V. Berezhnov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Prevalence and determinants of carotid plaque in the cross-sectional REFINE-Reykjavik study

(2016) Ran Sturlaugsdottir et al.   BMJ Open

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

(2016) Larisa V. Kovtonyuk et al.   Frontiers in Immunology

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

(2015) Mandy OJ Grootaert et al.   Autophagy

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function

(2015) Rui Yang et al.   eLife

Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering

(2014) Martin Mæng Bjørklund et al.   CIRCULATION RESEARCH

Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue

(2014) JIAN-ZHENG ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

IL-6 biology: implications for clinical targeting in rheumatic disease

(2014) Leonard H. Calabrese et al.   Nature Reviews Rheumatology

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations

(2013) Randall C Thompson et al.   LANCET

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Nix: A receptor protein for mitophagy in mammals

(2010) Tomotake Kanki   Autophagy

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Resistance to High-Fat Diet-Induced Obesity and Insulin Resistance in Mice with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency

(2010) Dongyan Zhang et al.   Cell Metabolism

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes

(2009) Alan R. Collins et al.   CIRCULATION RESEARCH

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model

(2007) Monika Madan et al.   ATHEROSCLEROSIS