Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating Snail transcriptional activity and stability

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition

(2021) Qiu-di Deng et al.   ACTA PHARMACOLOGICA SINICA

Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition

(2021) Jie Gao et al.   CELL DEATH AND DIFFERENTIATION

Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma

(2021) Silvia Pietrobono et al.   ONCOGENE

The essential role of PRAK in tumor metastasis and its therapeutic potential

(2021) Yuqing Wang et al.   Nature Communications

Communication Between Epithelial–Mesenchymal Plasticity and Cancer Stem Cells: New Insights Into Cancer Progression

(2021) Xiaobo Zheng et al.   Frontiers in Oncology

SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3

(2021) Yong Teng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease

(2021) Ashley N. Sigafoos et al.   Cancers

Aurora B induces epithelial–mesenchymal transition by stabilizing Snail1 to promote basal-like breast cancer metastasis

(2020) Jianchao Zhang et al.   ONCOGENE

Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer

(2020) Xueping Lei et al.   Cell Death & Disease

GANT-61 Induces Autophagy and Apoptosis in Glioblastoma Cells despite their heterogeneity

(2020) Gabriela Basile Carballo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

HDAC8 promotes the dissemination of breast cancer cells via AKT/GSK-3β/Snail signals

(2020) Panpan An et al.   ONCOGENE

EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability

(2020) Xiaobin Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs

(2020) Joshua Kapere Ochieng et al.   ONCOGENE

AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation

(2020) Han Tian et al.   Nature Communications

Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis

(2019) Chen Wei et al.   Molecular Cancer

p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation that is Required for GSK3β-βTrCP-Induced Snail Degradation

(2019) Ki-Jun Ryu et al.   CANCER RESEARCH

GLI1 activation by non-classical pathway integrin αvβ3/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis

(2019) Hui Dong et al.   Cell Death & Disease

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

(2019) Silvia Pietrobono et al.   Frontiers in Genetics

TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment

(2019) Sherona R. Sirkisoon et al.   ONCOGENE

Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells

(2019) Michael Torsten Meister et al.   CANCER LETTERS

Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

(2018) Jente van Staalduinen et al.   ONCOGENE

Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma

(2018) Zhihong Yao et al.   Cell Death & Disease

Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer

(2018) Zachary A. Yochum et al.   ONCOGENE

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

(2017) Shucai Yang et al.   Molecular Cancer

SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis

(2017) Y Liu et al.   ONCOGENE

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

(2017) A Po et al.   ONCOGENE

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

(2017) Deepika Neelakantan et al.   Nature Communications

Gli is activated and promotes epithelial-mesenchymal transition in human esophageal adenocarcinoma

(2017) Lei Wang et al.   Oncotarget

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

(2016) Jill E. Larsen et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription factor glioma-associated oncogene homolog 1 is required for transforming growth factor-β1-induced epithelial-mesenchymal transition of non-small cell lung cancer cells

(2015) HUA LI et al.   Molecular Medicine Reports

Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions

(2015) Dongsheng Gu et al.   Cancers

Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas

(2014) Dongsheng Yue et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The effects of sonic hedgehog signaling pathway components on non-small-cell lung cancer progression and clinical outcome

(2014) Jinwook Hwang et al.   World Journal of Surgical Oncology

The glioma-associated oncogene homolog 1 promotes epithelial–mesenchymal transition in human esophageal squamous cell cancer by inhibiting E-cadherin via Snail

(2013) S Min et al.   CANCER GENE THERAPY

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GLI1 Inhibition Promotes Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells

(2011) S. Joost et al.   CANCER RESEARCH

Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer

(2011) Guy Raz et al.   LUNG CANCER