Article
Oncology
Huiru Yang, Zhen Wei, Yifan Song, Kexin Du, Nannan Yin, Hong Lu, Bingbing Li, Lili Hou, Panfei Xing, Liang Chen, Chaojie Wang, Songqiang Xie
Summary: This study found that NUAK1 is highly expressed in esophageal squamous cell carcinoma (ESCC) and is associated with tumor invasion depth, lymph node metastasis, and poor prognosis. Moreover, NUAK1 promotes the migration and invasion of ESCC cells by activating the JNK/c-Jun/Slug signaling pathway.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
Xiuying Chen, Li Yu, Junyang Zhou, Ji Ren, Shan Wang, Yujie Tan, Yan Ding
Summary: In esophageal squamous cell carcinoma, both NFE2L2 and SQSTM1 (p62) are upregulated and promote tumor progression and epithelial-mesenchymal transition (EMT) through autophagy activity. Inhibiting both proteins simultaneously can reverse the migration and EMT characteristics of the tumor, suggesting that targeting both proteins may be a viable treatment option for esophageal squamous cell carcinoma.
Article
Oncology
Meng Gao, Chengjie Mei, Yonghua Guo, Peng Xia, Hao Zhang, Yinyi Liu, Ye Yao, Xiang Jiang, Yufeng Yuan, Yawei Qian
Summary: Intrahepatic cholangiocarcinoma (ICC) is a commonly diagnosed malignancy with poor prognosis due to lack of effective treatment methods. The protein aPKC-iota plays a role in promoting metastasis of ICC cells through regulating epithelial mesenchymal transition (EMT) and glucose metabolism. Additionally, FBP1 is found to inhibit malignant properties of ICC cells by antagonizing aPKC-iota, providing insights into potential new treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xiang Long, Ding-Guo Wang, Zhi-Bo Wu, Zhong-Min Liao, Jian-Jun Xu
Summary: This study investigated the potential role of SWT1-derived circRNAs in non-small-cell lung cancer (NSCLC) and found that circSWT1 promoted the invasion, migration, and epithelial-mesenchymal transition (EMT) of NSCLC. These findings suggest that circSWT1 could serve as a potential biomarker and therapeutic target for NSCLC.
Article
Oncology
Yan Zhao, Jiajia Gao, Xiufeng Xie, Peng Nan, Fang Liu, Yulin Sun, Xiaohang Zhao
Summary: The study demonstrated that BACH1 is overexpressed in ESCC tissues, associated with poor prognosis. BACH1 enhances migration and invasion in ESCC, promotes EMT and angiogenesis, and may serve as a promising therapeutic target or molecular marker in ESCC.
Article
Oncology
Boli Yang, Qiuyu Chen, Changshan Wan, Siyuan Sun, Lanping Zhu, Zhizhong Zhao, Weilong Zhong, Bangmang Wang
Summary: Transgelin is found to be expressed at low levels in ESCC, and its expression is positively correlated with the prognosis of ESCC patients. It inhibits the malignant progression of ESCC by suppressing the occurrence of EMT, as its overexpression significantly reduces cell invasion and proliferation abilities, while its knockdown promotes cell proliferation, migration, and invasion.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Viktoria Pider, Ira-Ida Skvortsova, Dragana Savic, Herbert Riechelmann
Summary: Mitochondrial dysfunction can induce epithelial mesenchymal transition in head and neck cancer cell lines, thereby promoting cancer aggressiveness and metastasis. However, this phenomenon is observed only in one of the cell lines.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jinping Liu, Huajun Feng, Dingting Wang, Yuanyuan Wang, Jian Luo, Shengen Xu, Feipeng Zhao, Gang Qin
Summary: This study aims to explore the role and mechanism of HOXA13 in nasopharyngeal carcinoma (NPC). The results show that HOXA13 is upregulated in NPC and promotes the proliferation, migration, and invasion of tumor cells. Additionally, the expression of HOXA13 is correlated with Snail and MMP-2.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Jinping Liu, Huajun Feng, Dingting Wang, Yuanyuan Wang, Jian Luo, Shengen Xu, Feipeng Zhao, Gang Qin
Summary: This study aimed to explore the role of HOXA13 in nasopharyngeal carcinoma (NPC) and its underlying mechanism. The results showed that upregulation of HOXA13 promoted proliferation, migration, and invasion of NPC cells, and was associated with increased expression of Snail and MMP-2. Therefore, HOXA13 acts as a cancer-promoting gene in NPC.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Xingjie Ma, Weibo Qi, Fan Yang, Huan Pan
Summary: JOSD1 is significantly overexpressed in LUAD and stabilizes Snail protein through deubiquitination, thereby promoting LUAD metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ying Huang, Yun Guo, Yi Xu, Fei Liu, Suli Dai
Summary: In this study, the upregulation of Flotillin-1 in gastric cancer was observed and correlated with a worse prognosis. Overexpression of Flotillin-1 enhanced the migration and invasion ability of gastric cancer cells, while knockdown of Flotillin-1 inhibited metastasis. Flotillin-1 promoted gastric cancer cell metastasis through inducing EMT process.
Review
Medicine, General & Internal
Katarzyna Wieczorek-Szukala, Andrzej Lewinski
Summary: Despite the usually indolent behavior and relatively good overall prognosis of thyroid carcinomas, they can exhibit high invasiveness and metastatic tendencies in some cases. The zinc-finger transcription factor Snail-1 is a well-known regulator of cancer invasiveness, playing a key role in inducing EMT and regulating chemoresistance and CSC formation in thyroid cancer cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yan Luo, Qingyun Zhu, Shasha Xiang, Qi Wang, Jun Li, Xiguang Chen, Wen Yan, Jianbo Feng, Xuyu Zu
Summary: A novel metastasis suppressive circular RNA, circPOKE, has been identified in breast cancer. circPOKE binds to USP10 and reduces its binding to Snail, thereby affecting Snail stability and inhibiting the metastatic potential of breast cancer cells through the protein-ubiquitination degradation pathway. Additionally, circPOKE can be secreted into the extracellular space via exosomes and significantly inhibits the invasive capabilities of breast cancer cells. These findings suggest that circPOKE may serve as a potential therapeutic target for breast cancer metastasis.
Article
Multidisciplinary Sciences
Shipra Kanti Jena, Shreya Das, Shreeta Chakraborty, Rupasri Ain
Summary: Trophectoderm cells of the blastocyst are the precursor of the placenta that is comprised of trophoblast, endothelial and smooth muscle cells. The molecular regulation of EMT during placental development and trophoblast differentiation still remained elusive.
SCIENTIFIC REPORTS
(2023)