Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophy

Cell cycle re-entry and arrest in G2/M phase induces senescence and fibrosis in Fuchs Endothelial Corneal Dystrophy

(2021) Tomas L. White et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing

(2021) Anna Altshuler et al.   Cell Stem Cell

Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea

(2021) De-Quan Li et al.   Ocular Surface

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics

(2020) Gaurang Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis

(2020) Tavé van Zyl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis

(2020) Stephan Ong Tone et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina

(2019) Yi-Rong Peng et al.   CELL

Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification

(2019) Brian S. Clark et al.   NEURON

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

NEAT1 is overexpressed in Parkinson’s disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress

(2019) Alon Simchovitz et al.   FASEB JOURNAL

Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis

(2019) Yuqiong Hu et al.   PLOS BIOLOGY

Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis

(2019) Min Zhang et al.   Artificial Cells Nanomedicine and Biotechnology

Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa

(2019) Cia-Hin Lau et al.   Molecular Therapy-Nucleic Acids

A single‐cell transcriptome atlas of the adult human retina

(2019) Samuel W Lukowski et al.   EMBO JOURNAL

Passaging capability of human corneal endothelial cells derived from old donors with and without accelerating cell attachment

(2019) Mohit Parekh et al.   EXPERIMENTAL EYE RESEARCH

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

(2019) Madhvi Menon et al.   Nature Communications

Loss of NQO1 generates genotoxic estrogen-DNA adducts in Fuchs Endothelial Corneal Dystrophy

(2019) Taiga Miyajima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation

(2019) Sébastien J. Dumas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected

(2019) Cailing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling

(2019) Qingnan Liang et al.   Nature Communications

Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation

(2018) Szandor Simmons et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gene expression in the corneal endothelium of Fuchs endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4

(2018) Eric D. Wieben et al.   PLoS One

Scleral hypoxia is a target for myopia control

(2018) Hao Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

(2018) Bruce A. Rheaume et al.   Nature Communications

Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells

(2018) Abu Shufian Ishtiaq Ahmed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fuchs Endothelial Corneal Dystrophy Through the Prism of Oxidative Stress

(2018) Ula V. Jurkunas   CORNEA

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma

(2017) Jeffrey O’Callaghan et al.   HUMAN MOLECULAR GENETICS

Characterization and Prospective of Human Corneal Endothelial Progenitors

(2017) Yongsong Liu et al.   International Journal of Medical Sciences

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

(2017) Julia Joung et al.   Nature Protocols

Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics

(2016) Karthik Shekhar et al.   CELL

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

(2015) Monika S. Kowalczyk et al.   GENOME RESEARCH

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli

(2014) Katsutoshi Imamura et al.   MOLECULAR CELL

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

(2014) H Choudhry et al.   ONCOGENE

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

(2014) Dimple Chakravarty et al.   Nature Communications

Paraspeckle formation during the biogenesis of long non-coding RNAs

(2013) Takao Naganuma et al.   RNA Biology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Corneal transplantation

(2012) Donald TH Tan et al.   LANCET

Cochlin, Intraocular Pressure Regulation and Mechanosensing

(2012) Manik Goel et al.   PLoS One

Differing Roles for TCF4 and COL8A2 in Central Corneal Thickness and Fuchs Endothelial Corneal Dystrophy

(2012) Robert P. Igo et al.   PLoS One

Mitochondrial DNA copy number and function decrease with age in the short-lived fishNothobranchius furzeri

(2011) Nils Hartmann et al.   AGING CELL

Proliferative capacity of corneal endothelial cells

(2011) Nancy C. Joyce   EXPERIMENTAL EYE RESEARCH

An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis

(2011) A. S. Jun et al.   HUMAN MOLECULAR GENETICS

Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo

(2010) Ping-Pin Zheng et al.   ANNALS OF NEUROLOGY

N-acetylcysteine, reactive oxygen species and beyond

(2010) Shi-Yong Sun   CANCER BIOLOGY & THERAPY

New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8

(2010) Veronique Vitart et al.   HUMAN MOLECULAR GENETICS

Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts

(2009) Ajay Sharma et al.   BRAIN RESEARCH BULLETIN

E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases

(2009) Shweta Tyagi et al.   EMBO JOURNAL

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH