Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

Release of a disordered domain enhances HspB1 chaperone activity toward tau

(2020) Hannah E. R. Baughman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nuclear phosphoinositide kinase complex regulates p53

(2019) Suyong Choi et al.   NATURE CELL BIOLOGY

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis

(2019) Riccardo De Santis et al.   Cell Reports

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

(2018) Takuya Yoshizawa et al.   CELL

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

(2018) Lin Guo et al.   CELL

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

(2018) Seema Qamar et al.   CELL

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

(2018) Dezerae Cox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation

(2018) Feng Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation

(2018) Feng Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization

(2018) Zhenying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

(2018) Rebecca Freilich et al.   Nature Communications

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

(2018) Javier Oroz et al.   Nature Communications

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ALS-Related Mutant FUS Protein Is Mislocalized to Cytoplasm and Is Recruited into Stress Granules of Fibroblasts from Asymptomatic FUS P525L Mutation Carriers

(2017) Margherita Lo Bello et al.   Neurodegenerative Diseases

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

(2017) Lorenzo Errichelli et al.   Nature Communications

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

(2016) Massimo Ganassi et al.   MOLECULAR CELL

Phase Separation: Linking Cellular Compartmentalization to Disease

(2016) Adriano Aguzzi et al.   TRENDS IN CELL BIOLOGY

A molecular mechanism of chaperone-client recognition

(2016) L. He et al.   Science Advances

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Phosphomimics Destabilize Hsp27 Oligomeric Assemblies and Enhance Chaperone Activity

(2015) Blagojce Jovcevski et al.   CHEMISTRY & BIOLOGY

Structure of the α-crystallin domain from the redox-sensitive chaperone, HSPB1

(2015) Ponni Rajagopal et al.   JOURNAL OF BIOMOLECULAR NMR

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

(2015) Kathleen A. Burke et al.   MOLECULAR CELL

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

(2015) Andi Mainz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuropathy- and myopathy-associated mutations in human small heat shock proteins: Characteristics and evolutionary history of the mutation sites

(2014) Rainer Benndorf et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The structured core domain of  B-crystallin can prevent amyloid fibrillation and associated toxicity

(2014) G. K. A. Hochberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Regulated structural transitions unleash the chaperone activity of  B-crystallin

(2013) J. Peschek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

(2012) Justin J. Yerbury et al.   CELL STRESS & CHAPERONES

Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau

(2011) Stefan Bibow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

P525L FUS mutation is consistently associated with a severe form of juvenile Amyotrophic Lateral Sclerosis

(2011) Amelia Conte et al.   NEUROMUSCULAR DISORDERS

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

(2010) Dorothee Dormann et al.   EMBO JOURNAL

Kinetics of Amyloid β Monomer-to-Oligomer Exchange by NMR Relaxation

(2010) Nicolas L. Fawzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation Dependence of Hsp27 Multimeric Size and Molecular Chaperone Function

(2009) David Hayes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation

(2009) Adriano Chiò et al.   NEUROBIOLOGY OF AGING

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

(2007) Paul S. Sharp et al.   NEUROBIOLOGY OF DISEASE