Vulnerability of newly synthesized proteins to proteostasis stress

Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB

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Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

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Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis

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The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

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Identification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines

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Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

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TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1

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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis

(2011) M. R. Domingo-Sananes et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A yeast functional screen predicts new candidate ALS disease genes

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Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

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Mitochondrial dynamics in cell death and neurodegeneration

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Autophagy gone awry in neurodegenerative diseases

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Chaperone networks: Tipping the balance in protein folding diseases

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Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

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Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease

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Rapid Label-Free Identification of Estrogen-Induced Differential Protein ExpressionIn Vivofrom Mouse Brain and Uterine Tissue

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Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

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A Limited Role for Disulfide Cross-linking in the Aggregation of Mutant SOD1 Linked to Familial Amyotrophic Lateral Sclerosis

(2008) Celeste M. Karch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

(2008) Balasubrahmanyam Medicherla et al.   JOURNAL OF CELL BIOLOGY

Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies

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TAR-DNA Binding Protein 43 in Pick Disease

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Adapting Proteostasis for Disease Intervention

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TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

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Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis

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