TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms

Alternative splicing modulates cancer aggressiveness: role in EMT/metastasis and chemoresistance

(2021) Debanwita Roy Burman et al.   MOLECULAR BIOLOGY REPORTS

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer

(2021) Maciej Cieśla et al.   MOLECULAR CELL

CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation

(2021) Qian Guo et al.   ONCOLOGY REPORTS

SRp20: a potential therapeutic target for human tumors

(2021) Han Wang et al.   PATHOLOGY RESEARCH AND PRACTICE

Alternative splicing perturbation landscape identifies RNA binding proteins as potential therapeutic targets in cancer

(2021) Junyi Li et al.   Molecular Therapy-Nucleic Acids

Targeting TDP‐43 proteinopathy with drugs and drug‐like small molecules.

(2020) Emanuele Buratti   BRITISH JOURNAL OF PHARMACOLOGY

Roles and mechanisms of alternative splicing in cancer — implications for care

(2020) Sophie C. Bonnal et al.   Nature Reviews Clinical Oncology

CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy

(2020) Yuncheng Bei et al.   Advanced Science

Emerging Roles of SRSF3 as a Therapeutic Target for Cancer

(2020) Zhixia Zhou et al.   Frontiers in Oncology

Drug delivery systems based on CD44-targeted glycosaminoglycans for cancer therapy

(2020) Min Li et al.   CARBOHYDRATE POLYMERS

CD44 as a tumor biomarker and therapeutic target

(2020) Hanxiao Xu et al.   Experimental Hematology & Oncology

CD44 splice isoform switching determines breast cancer stem cell state

(2019) Honghong Zhang et al.   GENES & DEVELOPMENT

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

(2019) Eric Wang et al.   CANCER CELL

Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence

(2019) Ting Shen et al.   Aging-US

Targeting mRNA processing as an anticancer strategy

(2019) Joana Desterro et al.   NATURE REVIEWS DRUG DISCOVERY

Inducible formation of leader cells driven by CD44 switching gives rise to collective invasion and metastases in luminal breast carcinomas

(2019) Cuixia Yang et al.   ONCOGENE

Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis

(2019) SungHee Park et al.   Cell Reports

The biology and role of CD44 in cancer progression: therapeutic implications

(2018) Chen Chen et al.   Journal of Hematology & Oncology

Sequence, Structure, and Context Preferences of Human RNA Binding Proteins

(2018) Daniel Dominguez et al.   MOLECULAR CELL

CD44v9 as a poor prognostic factor of triple-negative breast cancer treated with neoadjuvant chemotherapy

(2018) Eriko Tokunaga et al.   Breast Cancer

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

(2018) Teruo Yamauchi et al.   Oncotarget

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells

(2018) Xiaobai Liu et al.   Molecular Therapy-Nucleic Acids

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

(2018) André Kahles et al.   CANCER CELL

Cancer stem cells (CSCs) in cancer progression and therapy

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transcription and Splicing Factor TDP-43: Role in Regulation of Gene Expression in Testis

(2017) Prabhakara Reddi   SEMINARS IN REPRODUCTIVE MEDICINE

A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity

(2017) Jing Hu et al.   Cell Death & Disease

Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines

(2017) Yung-Lung Chang et al.   Oncotarget

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

(2016) Dany Nassar et al.   Annual Review of Pathology-Mechanisms of Disease

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration

(2016) C Turnquist et al.   CELL DEATH AND DIFFERENTIATION

CD44: More than a mere stem cell marker

(2016) I. Morath et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Increased cytoplasmicTARDBPmRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43

(2016) Akihide Koyama et al.   NUCLEIC ACIDS RESEARCH

Splicing-factor alterations in cancers

(2016) Olga Anczuków et al.   RNA

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells

(2015) Masahiko Ajiro et al.   NUCLEIC ACIDS RESEARCH

Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis

(2015) S Zhu et al.   ONCOGENE

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target

(2015) Yongmin Yan et al.   Stem Cells Translational Medicine

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520

(2013) Yun-Yong Park et al.   HEPATOLOGY

Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing

(2013) Shatakshi Pandit et al.   MOLECULAR CELL

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

(2012) Y Tang et al.   ONCOGENE

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

(2012) Toshifumi Yae et al.   Nature Communications

Muscle-Specific Splicing Factors ASD-2 and SUP-12 Cooperatively Switch Alternative Pre-mRNA Processing Patterns of the ADF/Cofilin Gene in Caenorhabditis elegans

(2012) Genta Ohno et al.   PLoS Genetics

The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes

(2012) Minna-Liisa Änkö et al.   GENOME BIOLOGY

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

(2011) James R Tollervey et al.   NATURE NEUROSCIENCE

TDP-43 regulates its mRNA levels through a negative feedback loop

(2010) Youhna M Ayala et al.   EMBO JOURNAL

Computational identification of tissue-specific alternative splicing elements in mouse genes from RNA-Seq

(2010) Ji Wen et al.   NUCLEIC ACIDS RESEARCH

SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans

(2009) F. Piva et al.   BIOINFORMATICS

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

The  -catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression

(2008) V. Goncalves et al.   RNA

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

(2007) Emanuele Buratti   Frontiers in Bioscience-Landmark