Review
Oncology
Jian Xiong, Yinshuang Chen, Weipeng Wang, Jing Sun
Summary: SRSF3, abnormally expressed in tumors, plays important roles in promoting tumorigenesis and cell proliferation, inhibiting cell senescence and apoptosis, and significantly inhibiting the proliferation and metastasis of tumor cells.
Article
Developmental Biology
Brenna J. C. Dennison, Eric D. Larson, Rui Fu, Julia Mo, Katherine A. Fantauzzol
Summary: Signaling through PDGFR alpha is important for craniofacial development, and this study reveals that Srsf3, phosphorylated downstream of PI3K-mediated signaling, plays a critical role in regulating gene expression changes and neural crest cell proliferation. The ablation of Srsf3 in mouse neural crest lineage leads to facial clefting, highlighting the significance of alternative RNA splicing in PDGFR alpha-dependent intracellular signaling in craniofacial development.
Article
Oncology
Chunxia Zhang, Yinshuang Chen, Fuchao Li, Man Yang, Fanyi Meng, Yawen Zhang, Weichang Chen, Weipeng Wang
Summary: The study identified SRSF3 as a splicing factor involved in the regulation of B7-H3 expression, impacting the prognosis of CRC patients. High expression of SRSF3 and B7-H3 correlates with poor patient outcomes, suggesting SRSF3 as a potential target for regulating B7-H3 expression and CRC therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Yinshuang Chen, Man Yang, Fanyi Meng, Yawen Zhang, Mengmeng Wang, Xuqin Guo, Jie Yang, Hongjian Zhang, Haiyang Zhang, Jing Sun, Weipeng Wang
Summary: SRSF3 is involved in the angiogenesis of colorectal cancer (CRC) by regulating the splicing of SRF. Silencing of SRSF3 inhibits angiogenesis and provides a new direction for antiangiogenic therapy in CRC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rong Jia, Zhi-Ming Zheng
Summary: This article summarizes the important role of SRSF3 in cellular processes, including regulation of RNA biogenesis and processing, and its involvement in tumorigenesis. It also introduces the gene, mRNA, and protein structure of SRSF3, the regulatory mechanisms of SRSF3 expression, and the characteristics of SRSF3 targets and binding sequences that contribute to its diverse molecular and cellular functions in tumorigenesis and human diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shenglei Feng, Jinmei Li, Hui Wen, Kuan Liu, Yiqian Gui, Yujiao Wen, Xiaoli Wang, Shuiqiao Yuan
Summary: This study reveals the mechanism of alternative splicing regulation by hnRNPH1 in germ cells and demonstrates its roles in both male and female germ cells, highlighting its importance in germ cell development.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Anthony J. Murphy, Alex H. Li, Peichao Li, Hong Sun
Summary: Alternative splicing plays a crucial role in diversifying the proteome and has significant implications in cancer development. Recent studies have highlighted the important roles of SR proteins in cancer progression. Understanding the spliceosome and its relationship to cancer has opened up new opportunities for therapeutic interventions based on alternative splicing.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yang Pan, John W. Phillips, Beatrice D. Zhang, Miyako Noguchi, Eric Kutschera, Jami McLaughlin, Pavlo A. Nesterenko, Zhiyuan Mao, Nathanael J. Bangayan, Robert Wang, Wendy Tran, Harry T. Yang, Yuanyuan Wang, Yang Xu, Matthew B. Obusan, Donghui Cheng, Alex H. Lee, Kathryn E. Kadash-Edmondson, Ameya Champhekar, Cristina Puig-Saus, Antoni Ribas, Robert M. Prins, Christopher S. Seet, Gay M. Crooks, Owen N. Witte, Yi Xing
Summary: This study describes a computational platform called IRIS that can discover tumor antigens derived from alternative splicing, providing potential targets for TCR and CAR-T immunotherapies. Through the analysis of transcriptomics and immuno-peptidomics data, the study demonstrates that the predicted targets by IRIS can bind with HLA molecules. The study illustrates the contribution of alternative splicing to the repertoire of tumor antigens and demonstrates the utility of IRIS in discovering AS-derived antigens and expanding cancer immunotherapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Yawen Zhang, Mengmeng Wang, Fanyi Meng, Man Yang, Yinshuang Chen, Xuqin Guo, Weiwei Wang, Yifan Zhu, Yundi Guo, Chunlai Feng, Shen Tian, Hongjian Zhang, Huanqiu Li, Jing Sun, Weipeng Wang
Summary: The high expression of SRSF3 in colorectal cancer (CRC) tissues plays a key role in the proliferation and migration of CRC cells. The novel SRSF3 inhibitor, SFI003, effectively suppresses CRC cell growth through the SRSF3/DHCR24/reactive oxygen species (ROS) pathway.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Carmelo Gurnari, Simona Pagliuca, Valeria Visconte
Summary: Alternative RNA splicing is an essential physiological function that plays a crucial role in cellular development. RNA splicing dysfunction has been implicated in the development of several cancers, including myeloid malignancies. Cancer cells exhibit marked gene expression alterations, including different usage of AS isoforms, potentially causing tissue-specific effects and disruptions of downstream pathways.
Review
Oncology
Zhi-Man Zhu, Fu-Chun Huo, Jian Zhang, Hong-Jian Shan, Dong-Sheng Pei
Summary: N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes, and it significantly influences various aspects of RNA metabolism. Pre-mRNA alternative splicing, a process that generates multiple splice isoforms, contributes to protein diversity in mammals. There is crosstalk between m6A modification and alternative splicing, where m6A modifications on pre-mRNAs regulate alternative splicing patterns by recruiting specific RNA-binding proteins or directly influencing the interaction between proteins and RNAs. Alternative splicing can also impact the deposition or recognition of m6A modification on mRNAs.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Zhi-Man Zhu, Fu-Chun Huo, Jian Zhang, Hong-Jian Shan, Dong-Sheng Pei
Summary: The crosstalk between m6A modification and alternative splicing plays crucial biological roles in tumorigenesis. Understanding the regulation of alternative splicing by m6A modification contributes to the development of tumor therapy strategies.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Yunze Liu, Xin Liu, Changwei Lin, Xianhong Jia, Hongmei Zhu, Jun Song, Yi Zhang
Summary: AS and ncRNAs play crucial roles in cancer by influencing the development of various diseases, especially in different aspects of cancer progression. Acting as regulatory molecules, ncRNAs can affect cell signaling pathways by influencing AS, thus impacting cancer progression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Endocrinology & Metabolism
Panyisha Wu, Moya Zhang, Nicholas J. G. Webster
Summary: Alternative RNA splicing is an important biological process that has been linked to various clinical syndromes, but its applicability to common diseases is still uncertain. This review focuses on the changes in alternative RNA splicing in fatty liver disease and the role of splicing regulation in disease progression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chaowei Wen, Zhujun Tian, Lan Li, Tongke Chen, Huajian Chen, Jichen Dai, Zhenzhen Liang, Shumei Ma, Xiaodong Liu
Summary: This study reveals the competitive antagonistic interaction of SRSF3 and HNRNPH1 in regulating the alternative splicing of PRMT5 induced by ionizing radiation (IR). Downregulation of SRSF3 leads to an increased level of PRMT5-ISO5, which enhances cancer cell radiosensitivity. In vivo experiments confirm that IR induces increased levels of PRMT5-ISO5, which in turn enhances tumor killing and regression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Zhixia Zhou, Zhan Wang, Jie Gao, Zhijuan Lin, Yin Wang, Peipei Shan, Mengkun Li, Tingting Zhou, Peifeng Li
Summary: This review focuses on the regulation of noncoding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, in the crosstalk between macrophages and tumor cells in hepatocellular carcinoma (HCC). These ncRNAs act as oncogenes or tumor suppressors, contributing to tumor progression by regulating the physiological and pathological processes of tumor cells as well as controlling macrophage infiltration, activation, polarization, and function. The review also explores the potential therapeutic strategies targeting crosstalk-related ncRNAs for HCC treatment.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Cell Biology
Yanyan Gao, Deyu Zhang, Fei Wang, Dejiu Zhang, Peifeng Li, Kun Wang
Summary: The BRAF V600E mutation in thyroid cancer regulates cell death resistance by modulating the mitochondrial permeability transition. Overexpression of BRAF V600E attenuates cell death, while knockdown aggravates it. This study provides new intervention targets for BRAF V600E mutant tumors.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Lei Zhang, Yuan Zhang, Fei Yu, Xin Li, Huijuan Gao, Peifeng Li
Summary: This paper systematically reviews the role of circRNAs in myocardial infarction (MI) and explores their potential in diagnosis and clinical therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Hongjing Cai, Pengchao Tian, Jie Ju, Tao Wang, Xinzhe Chen, Kai Wang, Fei Wang, Xue Yu, Shaocong Wang, Yin Wang, Chan Shan, Peifeng Li
Summary: This study demonstrates that doxorubicin induces apoptosis in cardiomyocytes and identified a dysregulated long noncoding RNA (lncRNA), lnc5745, in doxorubicin-treated cardiomyocytes. Overexpression of lnc5745 alleviates cardiomyocyte apoptosis induced by doxorubicin both in vitro and in vivo, while silencing lnc5745 promotes cardiomyocyte apoptosis. Additionally, Rab2A, a direct target of lnc5745, has a protective effect in doxorubicin-induced cardiotoxicity. Mechanistically, Rab2A interacts with p53 and promotes its phosphorylation, thereby activating the apoptotic pathway.
CELL DEATH DISCOVERY
(2022)
Review
Fisheries
Zhixia Zhou, Yanxin He, Shoushi Wang, Yin Wang, Peipei Shan, Peifeng Li
Summary: Autophagy is a conserved cellular process essential for maintaining metabolism and energy balance, with implications in various physiological functions and clinical diseases. However, little is known about autophagy in teleost fish. This review provides an overview of the current knowledge of autophagy in teleosts, focusing on its physiological and pathological regulation in different processes. The potential options for targeting autophagy in teleosts for domestication, farming, or therapeutic strategies are also explored.
Review
Biotechnology & Applied Microbiology
Huijuan Gao, Xin Li, Xiatian Chen, Deng Hai, Chuang Wei, Lei Zhang, Peifeng Li
Summary: Probiotics are live microorganisms with health-promoting effects that are widely used in various fields. Lactobacillus acidophilus, an important human intestinal probiotic, has been extensively studied since its discovery in 1900, and has key roles in human health with potential applications in functional, edible probiotic preparations due to its resistance to acid and bile salts. Discussions on the research progress and future development of probiotic products are ongoing.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Qinrui Fu, Leilei Yu, Yin Wang, Peifeng Li, Jibin Song
Summary: Chronic diseases claim millions of lives every year, and it is important to develop advanced drugs for better treatment. Nanotheranostics, which integrate diagnosis and treatment into a single nanosystem, have shown great potential. However, their applications in nanomedicine are still in the early stages.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Medicine, Research & Experimental
Zeyu Jiang, Meihua Zhang, Peifeng Li, Yin Wang, Qinru Fu
Summary: Computed tomography (CT) is a widely used diagnostic tool in hospitals worldwide, but it faces limitations in distinguishing soft tissues from normal organs and tumors. To improve imaging sensitivity and contrast, various nanomaterial-based CT contrast agents have been developed. In this review, we discuss CT contrast agents based on gold (Au), bismuth (Bi), lanthanide (Ln), and transition metal (TM) nanomaterials, along with their applications in image-guided therapy. Additionally, we summarize the use of CT image-guided therapy for various diseases and highlight the future perspectives of CT contrast agents and their biomedical applications.
Review
Engineering, Biomedical
Congcong Li, Yin Wang, Pei-Feng Li, Qinrui Fu
Summary: Nucleic acid nanomaterials, which have good biocompatibility, biodegradability, and programmability, are often combined with inorganic nanomaterials to improve their biological stability. However, the undefined toxic side effects of composite nanocarriers hinder their in vivo application. Recently, nanostructures composed entirely of DNA oligonucleotides have been rapidly developed as a nanotool to avoid potential biotoxicity and have been applied in biomedicine. This review discusses the assembly strategies of pure nucleic acid nanomaterials based on rolling circle amplification products and their applications in biosensing, bioimaging, and biomedicine.
ACTA BIOMATERIALIA
(2023)
Review
Immunology
Zhixia Zhou, Cuibo Leng, Zhan Wang, Linhai Long, Yiju Lv, Ziru Gao, Yin Wang, Shoushi Wang, Peifeng Li
Summary: Research in the past two decades has confirmed that noncoding RNAs (ncRNAs), present in cells from yeast to vertebrates, are functional regulators involved in cellular and physiological processes. Dysregulation of ncRNAs is linked to imbalances in cellular homeostasis and the development of diseases. In mammals, ncRNAs like long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs), is the predominant mode of lncRNA-miRNA crosstalk. However, the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species have received little attention. This review provides an overview of the physiological and pathological regulation of the teleost lncRNA-miRNA-mRNA axis in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and stress-related immune responses. It also explores the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Xiao-Ru Liang, Yan-Fei Liu, Feng Chen, Zhi-Xia Zhou, Li-Jie Zhang, Zhi-Juan Lin
Summary: Long non-coding RNAs (lncRNAs) are involved in various biological processes and regulate key proteins in the cell cycle of cancer cells. Understanding their role in cell cycle regulation can lead to new therapeutic strategies for cancer treatment. This review article summarizes recent studies on lncRNA control of cell cycle-related proteins and discusses their emerging role in cancer diagnosis and therapy.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Cheng-Xi Li, Yu-Meng Wang, Wen-Jing Zhang, Shu Zhang, Jian-Ping Li, Tong Zhou, Jin-Ao Duan, Jian-Ming Guo
Summary: Inflammatory bowel disease can be alleviated by Chinese herbal medicine Abelmoschus manihot through promoting IL-10 secretion and modulating gut microbiota. This study provides evidence that the protective effects of AM on IBD are IL-10-dependent and mediated by its regulation on gut microbial dysbiosis.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tianxiang Li, Yanyan Yang, Hongzhao Qi, Weigang Cui, Lin Zhang, Xiuxiu Fu, Xiangqin He, Meixin Liu, Pei-feng Li, Tao Yu
Summary: CRISPR/Cas9 gene-editing technology is an ideal tool for treating diseases by repairing mutations or disrupting disease-causing genes. However, effectively delivering the CRISPR system to diseased cells in vivo is currently lacking, and nonviral vectors with target recognition functions may be the focus of future research. Pathological and physiological changes resulting from disease onset can be used for targeted delivery or gene editing.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Otorhinolaryngology
Changjiang Li, Yi Fang, Min Chen, Jian Chen, Haitao Wu, Peijie He, Lei Cheng
Summary: The application of CO2 laser surgery combined with a self-made laryngeal dilator is feasible and effective for the treatment of adult glottic stenosis.
ACTA OTO-LARYNGOLOGICA
(2023)
