The p53 network: cellular and systemic DNA damage responses in cancer and aging

Targeting a neoantigen derived from a common TP53 mutation

(2021) Emily Han-Chung Hsiue et al.   SCIENCE

Bispecific antibodies targeting mutant RAS neoantigens

(2021) Jacqueline Douglass et al.   Science Immunology

The central role of DNA damage in the ageing process

(2021) Björn Schumacher et al.   NATURE

Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance

(2021) Yong-Li Dong et al.   Communications Biology

Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens

(2020) Parisa Malekzadeh et al.   CLINICAL CANCER RESEARCH

P53 Mutant p53N236S Regulates Cancer-Associated Fibroblasts Properties Through Stat3 Pathway

(2020) Qing Liu et al.   OncoTargets and Therapy

p53 dynamics in single cells are temperature-sensitive

(2020) Marcel Jentsch et al.   Scientific Reports

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

(2020) Julianna Blagih et al.   Cell Reports

MDM2 inhibition: an important step forward in cancer therapy

(2020) Marina Konopleva et al.   LEUKEMIA

A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2

(2020) Dana Mamriev et al.   Cell Death & Disease

Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

(2020) Valeria Capaci et al.   Nature Communications

Unique TP53 neoantigen and the immune microenvironment in long-term survivors of Hepatocellular carcinoma

(2020) Huayu Yang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phosphorylation control of p53 DNA binding cooperativity balances tumorigenesis and aging

(2020) Oleg Timofeev et al.   CANCER RESEARCH

p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo

(2020) Sydney M. Moyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P53 ICE CRIM mouse: a tool to generate mutant allelic series in somatic cells and germ lines for cancer studies

(2019) Hsiang-Hsuan Fan et al.   FASEB JOURNAL

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

(2019) Winifred Lo et al.   Cancer Immunology Research

Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs

(2019) Betul Gok Yavuz et al.   Scientific Reports

Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells

(2019) Hui-Ling Ou et al.   DEVELOPMENTAL CELL

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

DNA damage responses in ageing

(2019) Paulo F. L. da Silva et al.   Open Biology

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment

(2019) Douglas D. Fang et al.   Journal for ImmunoTherapy of Cancer

Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis

(2019) Yan Stein et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Cell Death and Immunity by XIAP

(2019) Philipp J. Jost et al.   Cold Spring Harbor Perspectives in Biology

p53 isoforms regulate premature aging in human cells

(2018) Natalia von Muhlinen et al.   ONCOGENE

Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

(2018) Sharathchandra Arandkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner

(2018) Meital Charni-Natan et al.   Cell Death & Disease

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

(2018) Qiang Zhang et al.   Cell Death & Disease

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

(2018) Tomer Cooks et al.   Nature Communications

A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models

(2018) Yuhan Zhao et al.   eLife

Hypoxia and IF1 Expression Promote ROS Decrease in Cancer Cells

(2018) Gianluca Sgarbi et al.   Cells

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

(2018) Ling Liu et al.   Cell Stem Cell

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

(2018) David Novo et al.   Nature Communications

The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression

(2018) Alessandro Torgovnick et al.   Cell Reports

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

(2018) Tracy L. Habermehl et al.   GeroScience

Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death

(2017) Ludger Hauck et al.   PLoS One

InheritedTP53Mutations and the Li–Fraumeni Syndrome

(2017) Tanya Guha et al.   Cold Spring Harbor Perspectives in Medicine

Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres

(2017) Caitlin M. Roake et al.   Cold Spring Harbor Perspectives in Medicine

LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse

(2016) Valerio Rossi et al.   CELL DEATH AND DIFFERENTIATION

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

(2016) Leena Ackermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The tumour suppressor CYLD regulates the p53 DNA damage response

(2016) Vanesa Fernández-Majada et al.   Nature Communications

E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

(2016) Leena Ackermann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p53 in the DNA-Damage-Repair Process

(2016) Ashley B. Williams et al.   Cold Spring Harbor Perspectives in Medicine

Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation

(2015) M Charni et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

(2013) Valentina Gambino et al.   AGING CELL

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta

(2013) Shalom Madar et al.   PLoS One

Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function

(2012) Zhangfa Song et al.   AGING CELL

Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin

(2011) Hugh S. Gannon et al.   DEVELOPMENTAL BIOLOGY

Missense Mutations Located in Structural p53 DNA-Binding Motifs Are Associated With Extremely Poor Survival in Chronic Lymphocytic Leukemia

(2011) Martin Trbusek et al.   JOURNAL OF CLINICAL ONCOLOGY

HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase

(2010) Ataman Sendoel et al.   NATURE

Puma is required for p53-induced depletion of adult stem cells

(2010) Dongping Liu et al.   NATURE CELL BIOLOGY

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

The SCFFSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans

(2008) M X Gao et al.   CELL DEATH AND DIFFERENTIATION