p53 isoforms regulate premature aging in human cells

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

(2016) Phillip R. Musich et al.   Aging-US

p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage

(2015) Lu Gong et al.   CELL RESEARCH

DNA repair defects and genome instability in Hutchinson–Gilford Progeria Syndrome

(2015) Susana Gonzalo et al.   CURRENT OPINION IN CELL BIOLOGY

Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins

(2015) Sandra Vidak et al.   GENES & DEVELOPMENT

NF-κB activation impairs somatic cell reprogramming in ageing

(2015) Clara Soria-Valles et al.   NATURE CELL BIOLOGY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1

(2014) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence

(2014) Izumi Horikawa et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

(2013) Abdul M. Mondal et al.   JOURNAL OF CLINICAL INVESTIGATION

Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

(2012) R. P. McCord et al.   GENOME RESEARCH

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

(2012) Y Tang et al.   ONCOGENE

Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses

(2012) J. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-damage accumulation and replicative arrest in Hutchinson–Gilford progeria syndrome

(2011) Phillip R. Musich et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

(2011) F. G. Osorio et al.   Science Translational Medicine

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

(2010) Michelle Olive et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage

(2010) M Aoubala et al.   CELL DEATH AND DIFFERENTIATION

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Downregulation of Homologous Recombination DNA Repair Genes by HDAC Inhibition in Prostate Cancer Is Mediated through the E2F1 Transcription Factor

(2010) Sushant K. Kachhap et al.   PLoS One

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

(2009) Olga A. Sedelnikova et al.   AGING CELL

Lamin B1 controls oxidative stress responses via Oct-1

(2009) Ashraf N. Malhas et al.   JOURNAL OF CELL BIOLOGY

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

(2009) Kaori Fujita et al.   NATURE CELL BIOLOGY

The Isoforms of the p53 Protein

(2009) M. P. Khoury et al.   Cold Spring Harbor Perspectives in Biology

HGPS and related premature aging disorders: From genomic identification to the first therapeutic approaches

(2008) Sandrine Pereira et al.   MECHANISMS OF AGEING AND DEVELOPMENT

p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation

(2008) Ran Brosh et al.   Molecular Systems Biology

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A

(2007) Yiyong Liu et al.   FASEB JOURNAL