The central role of DNA damage in the ageing process

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

(2020) K. Brazhnik et al.   Science Advances

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

(2020) Yuka Nakazawa et al.   CELL

Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act

(2020) Sjoukje Lubberts et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

(2020) Erika Kelmer Sacramento et al.   Molecular Systems Biology

H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage

(2020) Siyao Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A C. elegans model for neurodegeneration in Cockayne syndrome

(2020) Amanda F C Lopes et al.   NUCLEIC ACIDS RESEARCH

Determinants of telomere length across human tissues

(2020) Kathryn Demanelis et al.   SCIENCE

DNA methylation GrimAge strongly predicts lifespan and healthspan

(2019) Ake T. Lu et al.   Aging-US

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

(2019) Khalid Alyodawi et al.   Journal of Cachexia Sarcopenia and Muscle

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

High levels of oxidatively generated DNA damage 8,5’-cyclo-2’-deoxyadenosine accumulate in the brain tissues of xeroderma pigmentosum group A gene-knockout mice

(2019) Toshio Mori et al.   DNA REPAIR

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

(2019) Lei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

(2019) Rui Gao et al.   eLife

Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells

(2019) Hui-Ling Ou et al.   DEVELOPMENTAL CELL

Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans

(2019) Ashley B. Williams et al.   GENETICS

DNA damage in aging, the stem cell perspective

(2019) Taylor McNeely et al.   HUMAN GENETICS

The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

(2019) Débora Kristina Alves-Fernandes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

(2019) Keren Yizhak et al.   SCIENCE

Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single cell resolution

(2019) Ryan O'Hara et al.   GENOME RESEARCH

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Nuclear Genomic Instability and Aging

(2018) Laura J. Niedernhofer et al.   Annual Review of Biochemistry

mTORC1 pathway in DNA damage response

(2018) Yinxing Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

(2018) Irene Franco et al.   Nature Communications

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

(2018) Panagiotis Kotsantis et al.   Cancer Discovery

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

(2018) Takahiro Ito et al.   Cell Reports

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging

(2018) Lei Zhang et al.   Annual Review of Genetics

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

(2018) Ling Liu et al.   Cell Stem Cell

Population dynamics of normal human blood inferred from somatic mutations

(2018) Henry Lee-Six et al.   NATURE

Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides

(2018) Franziska R. Traube et al.   Nature Protocols

Chromatin and nucleosome dynamics in DNA damage and repair

(2017) Michael H. Hauer et al.   GENES & DEVELOPMENT

Telomere-driven diseases and telomere-targeting therapies

(2017) Paula Martínez et al.   JOURNAL OF CELL BIOLOGY

DNA repair in the trinucleotide repeat disorders

(2017) Lesley Jones et al.   LANCET NEUROLOGY

Genome instability: Linking ageing and brain degeneration

(2017) Ari Barzilai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Crosstalk Among UV-Induced Inflammatory Mediators, DNA Damage and Epigenetic Regulators Facilitates Suppression of the Immune System

(2017) Ram Prasad et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans

(2017) Diletta Edifizi et al.   Cell Reports

mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice

(2016) Graham Dominick et al.   AGING CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Menopause: Genome stability as new paradigm

(2016) Joop S.E. Laven et al.   MATURITAS

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia

(2016) Nicolas C. Hoch et al.   NATURE

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

(2016) H. Matsumura et al.   SCIENCE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Role of Telomeres and Telomerase in Aging and Cancer

(2016) J. W. Shay   Cancer Discovery

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

(2016) Sara Sepe et al.   Cell Reports

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex

(2016) Marek Adamowicz et al.   Cell Reports

Whole Chromosome Instability induces senescence and promotes SASP

(2016) Grasiella Angelina Andriani et al.   Scientific Reports

Genetic evidence for common pathways in human age-related diseases

(2015) Simon C. Johnson et al.   AGING CELL

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

(2015) Felix R Day et al.   NATURE GENETICS

Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes

(2015) Mikhail Shaposhnikov et al.   Scientific Reports

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging

(2014) Z. Hu et al.   GENES & DEVELOPMENT

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances

(2014) Jérôme D. Robin et al.   GENES & DEVELOPMENT

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

(2014) Michael M. Mueller et al.   NATURE CELL BIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

DNA-repair in mild cognitive impairment and Alzheimer's disease

(2013) Nina Bucholtz et al.   DNA REPAIR

Nucleotide excision repair in chronic neurodegenerative diseases

(2013) Sara Sepe et al.   DNA REPAIR

Lymphocytes of Patients with Alzheimer’s Disease Display Different DNA Damage Repair Kinetics and Expression Profiles of DNA Repair and Stress Response Genes

(2013) Giovana Leandro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

(2013) Maria A. Ermolaeva et al.   NATURE

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Role of AMPK in UVB-induced DNA damage repair and growth control

(2012) C L Wu et al.   ONCOGENE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

DNA Damage and Impairment of DNA Repair in Alzheimer's Disease

(2010) M. Obulesu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

(2009) George A. Garinis et al.   NATURE CELL BIOLOGY

A two-step model for senescence triggered by a single critically short telomere

(2009) Pauline Abdallah et al.   NATURE CELL BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

(2008) Björn Schumacher et al.   PLoS Genetics