标题
The role of the STAT3 signaling transduction pathways in radioresistance
作者
关键词
Four Rs of radiotherapy, cancer stemness, DNA damage repair, Reoxygenation, Redistribution of the cell cycle, Repopulation
出版物
PHARMACOLOGY & THERAPEUTICS
Volume 234, Issue -, Pages 108118
出版商
Elsevier BV
发表日期
2022-01-24
DOI
10.1016/j.pharmthera.2022.108118
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- CXCR4 uses STAT3-mediated slug expression to maintain radioresistance of non-small cell lung cancer cells: emerges as a potential prognostic biomarker for lung cancer
- (2021) Jeong-Yub Kim et al. Cell Death & Disease
- Sinularin, an Anti-Cancer Agent Causing Mitochondria-Modulated Apoptosis and Cytoskeleton Disruption in Human Hepatocellular Carcinoma
- (2021) Chou-Yuan Ko et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies
- (2021) Vivek Kumar et al. Frontiers in Cell and Developmental Biology
- Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation
- (2021) Jinyun Dong et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Role of Cancer Stem Cells in Radiation Resistance
- (2020) Christoph Reinhold Arnold et al. Frontiers in Oncology
- The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells
- (2020) Chien-Han Yuan et al. BIOCHEMICAL PHARMACOLOGY
- Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response
- (2020) Emma McCann et al. Translational Oncology
- The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
- (2019) So-Yeon Park et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Revisiting the development of small molecular inhibitors that directly target the signal transducer and activator of transcription 3 (STAT3) domains
- (2019) Po-Chang Shih LIFE SCIENCES
- Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development
- (2018) Jacopo Sgrignani et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Enhancer of zeste homolog 2 (EZH2) inhibitors
- (2018) Nitya Gulati et al. LEUKEMIA & LYMPHOMA
- Targeting the PI3K pathway in cancer: are we making headway?
- (2018) Filip Janku et al. Nature Reviews Clinical Oncology
- Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide
- (2018) Lu Lu et al. ONCOGENE
- PI3K/AKT inhibition induces compensatory activation of the MET/STAT3 pathway in non‑small cell lung cancer
- (2018) Chunan Bian et al. Oncology Letters
- A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3)
- (2018) Po-Chang Shih et al. Oncotarget
- The STAT3/Slug Axis Enhances Radiation-Induced Tumor Invasion and Cancer Stem-like Properties in Radioresistant Glioblastoma
- (2018) Jang-Chun Lin et al. Cancers
- Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2
- (2017) Jia Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients
- (2017) Renata A. Tassi et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Overview of Cancer Stem Cells and Stemness for Community Oncologists
- (2017) Justin D. Lathia et al. Targeted Oncology
- IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma
- (2017) Chunbao Zang et al. Oncotarget
- Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization
- (2017) Hua Xiong et al. Journal of Cancer
- Targeting NEK2 as a promising therapeutic approach for cancer treatment
- (2016) Yanfen Fang et al. CELL CYCLE
- Targeting the AKT/cyclin D1 pathway to overcome intrinsic and acquired radioresistance of tumors for effective radiotherapy
- (2016) Tsutomu Shimura INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling
- (2016) Xiaoqing Wu et al. Oncotarget
- Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells
- (2016) Natalie Grinshtein et al. Oncotarget
- FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells
- (2016) Uday B. Maachani et al. Oncotarget
- Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer
- (2015) Gissela Borrego-Soto et al. GENETICS AND MOLECULAR BIOLOGY
- Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma
- (2015) Cheolhee Won et al. HEPATOLOGY
- Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)
- (2015) GEORGE MIHAI NITULESCU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- STAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in human hepatocellular carcinoma cells
- (2015) CHUANHAI ZHANG et al. ONCOLOGY REPORTS
- Suppression of cancer relapse and metastasis by inhibiting cancer stemness
- (2015) Youzhi Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STAT3-driven transcription depends upon the dimethylation of K49 by EZH2
- (2015) Maupali Dasgupta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner
- (2015) Sung-Hak Kim et al. Stem Cell Reports
- Myc Enforces Overexpression of EZH2 in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms
- (2015) Cheryl M. Koh et al. Oncotarget
- Hypoxia-mediated carbohydrate metabolism and transport promote early-stage murine follicle growth and survival
- (2014) Yogeshwar Makanji et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance
- (2014) Stefania Zona et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer
- (2014) L Chen et al. BRITISH JOURNAL OF CANCER
- Cancer stem cells and radioresistance
- (2014) Kiera Rycaj et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition
- (2014) Mutsuko Minata et al. PLoS One
- Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
- (2014) Yanjie Kong et al. PLoS One
- Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer
- (2014) Uddalak Bharadwaj et al. Cancers
- STAT3 Target Genes Relevant to Human Cancers
- (2014) Richard Carpenter et al. Cancers
- Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
- (2013) Eunhee Kim et al. CANCER CELL
- STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapyin vitroandin vivo
- (2013) Melanie Spitzner et al. INTERNATIONAL JOURNAL OF CANCER
- Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
- (2013) S. You et al. MOLECULAR CANCER THERAPEUTICS
- Stat3 Inhibitor Stattic Exhibits Potent Antitumor Activity and Induces Chemo- and Radio-Sensitivity in Nasopharyngeal Carcinoma
- (2013) Yunbao Pan et al. PLoS One
- Twist1 Promotes Gastric Cancer Cell Proliferation through Up-Regulation of FoxM1
- (2013) Jianxin Qian et al. PLoS One
- Targeting Head and Neck Cancer Stem Cells to Overcome Resistance to Photon and Carbon Ion Radiation
- (2013) Gérald Bertrand et al. Stem Cell Reviews and Reports
- Cucurbitacin E Induces G2/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes ApoptosisviaFas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells
- (2012) Wen-Wen Huang et al. Evidence-based Complementary and Alternative Medicine
- Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma
- (2012) Makoto Adachi et al. ORAL ONCOLOGY
- Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation, Survival and DNA Repair of K562 Cell Line
- (2012) André L. Mencalha et al. PLoS One
- HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway
- (2011) L Qiang et al. CELL DEATH AND DIFFERENTIATION
- CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation
- (2011) Terence Kin Wah Lee et al. Cell Stem Cell
- Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis
- (2011) Yi-Ping Yang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Inhibition of JAK2 Signaling by TG101209 Enhances Radiotherapy in Lung Cancer Models
- (2011) Yunguang Sun et al. Journal of Thoracic Oncology
- Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma
- (2011) James A. Bonner et al. RADIOTHERAPY AND ONCOLOGY
- The Src Inhibitor AZD0530 Blocks Invasion and May Act as a Radiosensitizer in Lung Cancer Cells
- (2010) Phillip R. Purnell et al. Journal of Thoracic Oncology
- Radiation Resistance of Cancer Stem Cells: The 4 R's of Radiobiology Revisited
- (2010) Frank Pajonk et al. STEM CELLS
- FoxM1, a critical regulator of oxidative stress during oncogenesis
- (2009) Hyun Jung Park et al. EMBO JOURNAL
- Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells
- (2009) Hui-Fang Li et al. Radiation Oncology
- Notch Promotes Radioresistance of Glioma Stem Cells
- (2009) Jialiang Wang et al. STEM CELLS
- STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells
- (2009) Maureen M. Sherry et al. STEM CELLS
- FoxM1B Transcriptionally Regulates Vascular Endothelial Growth Factor Expression and Promotes the Angiogenesis and Growth of Glioma Cells
- (2008) Yujian Zhang et al. CANCER RESEARCH
- The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition
- (2008) A. Vigneron et al. CANCER RESEARCH
- The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
- (2008) Sophie Beyer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia induces a hedgehog response mediated by HIF-1α
- (2008) Maarten F. Bijlsma et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Transcriptional up-regulation of FoxM1 in response to hypoxia is mediated by HIF-1
- (2008) Li-Min Xia et al. JOURNAL OF CELLULAR BIOCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now