Article
Pharmacology & Pharmacy
Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Shi
Summary: Glucocappasalin (GCP) from Descurainia sophia seeds shows potential antitumor activity in HeLa cervical carcinoma cells. GCP induces cell cycle G2/M-phase arrest, apoptosis, and autophagy by acting on the PI3K/AKT/mTOR signaling pathways, making it a promising agent for cervical cancer eradication.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Chen
Summary: The study suggests that Licochalcone A (LCA) has great therapeutic potential for esophageal cancer (EC) by regulating the p53 signaling pathway to induce cell cycle arrest and apoptosis. In vitro experiments showed that LCA inhibited EC cell proliferation, migration, and invasion, and promoted apoptosis. In vivo experiments demonstrated that LCA administration inhibited tumor growth without causing significant toxicities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tai-Hsin Tsai, Kuan-Ting Lee, Yi-Chiang Hsu
Summary: Cucurbitacin I (JSI-124) derived from Cucurbitaceae has the potential to induce apoptosis and cell cycle arrest in glioblastoma multiforme (GBM) cells. JSI-124 effectively reduced cell viability in GBM cells, leading to apoptosis and cell cycle arrest.
Article
Biochemistry & Molecular Biology
Jia-feng Tang, Guo-li Li, Tao Zhang, Yu-mei Du, Shi-ying Huang, Jian-hua Ran, Jing Li, Di-long Chen
Summary: In this study, it was found that HHT effectively inhibits the proliferation of melanoma cells by inducing DNA damage, apoptosis, and cell cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effect of HHT on melanoma, providing evidence for its potential as an anti-melanoma agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Zhiping He, Xingquan Liu, Fenghua Wu, Shaozhen Wu, Gary O'Neal Rankin, Ivan Martinez, Yon Rojanasakul, Yi Charlie Chen
Summary: The study demonstrated that gallic acid (GA) can inhibit ovarian cancer cell proliferation by promoting apoptosis and blocking cell cycle progression, indicating its potential preventive and therapeutic effects in ovarian cancer.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Shuai Man, Zhuzhu Wu, Rui Sun, Qi Guan, Zengqiang Li, Daiying Zuo, Weige Zhang, Yingliang Wu
Summary: The novel SMART analog W436 showed higher solubility, stability, and antitumor activity against HCC cells compared to SMART. It inhibited cell proliferation in a dose-dependent manner, with superior anticancer effects and mechanisms involving G2/M cell cycle arrest, apoptosis, and suppression of autophagy and epithelial-to-mesenchymal transition. W436 has promising potential for therapeutic treatment of HCC.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mengjiao Hao, Yijun Guo, Zhikang Zhang, Huihao Zhou, Qiong Gu, Jun Xu
Summary: This study discovers the anti-cancer effect of compound 5o on colorectal cancer cells. It inhibits cell proliferation and induces apoptosis through multiple signaling pathways. The target of compound 5o is identified as GRP94.
BIOORGANIC CHEMISTRY
(2022)
Article
Environmental Sciences
Yuan Liang, Tiehua Zhang, Li Ren, Siyuan Jing, Zhuolin Li, Peng Zuo, Tiezhu Li, Yongjun Wang, Jie Zhang, Zhengyi Wei
Summary: CuIIb was confirmed to induce apoptosis and inhibit proliferation in A549 cells via the STAT3 pathway, as well as suppress cell cycle and induce G2/M phase cell cycle arrest. CuIIb also suppressed the EGFR/MAPK pathway signal transmitting, highlighting its potential as an EGFR tyrosine kinase inhibitor.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siriphorn Chimplee, Sittiruk Roytrakul, Suchada Sukrong, Theera Srisawat, Potchanapond Graidist, Kanyanatt Kanokwiroon
Summary: The study found that 7HF derived from Grangea maderaspatana exhibits strong anti-TNBC activity and low toxicity to normal breast cells. The mechanism of action of 7HF involves regulating signal transduction associated with G2/M phase arrest and apoptosis.
Article
Oncology
Huocong He, Keyu Lin, Changyan Zou, Jianru Pan, Wankai Fu, Yan Zhou, Huamei Lin, Chao Chen, Ying Su
Summary: Annexin A2 (ANXA2) is associated with prognosis in nasopharyngeal carcinoma (NPC), with high expression leading to radioresistance. Knockdown of ANXA2 enhances radiosensitivity in NPC cells by inducing G2/M phase arrest, apoptosis, and activating the p38 MAPK-HSP27 pathway. ANXA2 may be a promising therapeutic target for overcoming radioresistance in NPC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Gazdova, Radka Michalkova, Martin Kello, Maria Vilkova, Zuzana Kudlickova, Janette Baloghova, Ladislav Mirossay, Jan Mojzis
Summary: This study focused on investigating the antiproliferative effects of chalcone hybrids, particularly the chalcone-acridine hybrid 1C, in melanoma cancer cells. The study revealed that 1C exhibited potent antiproliferative effects by inducing cell cycle arrest and apoptosis. Additionally, the study found that 1C modulated the expression or phosphorylation of specific cell cycle-associated proteins and activated the DNA damage response pathway. Furthermore, 1C also induced apoptosis by causing mitochondrial dysfunction and activating caspase 3/7. The study suggests that the chalcone-acridine hybrid 1C may have potential as an antimelanoma agent in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jiajing Niu, Jiamei Wang, Qi Zhang, Zhihua Zou, Yushuang Ding
Summary: The study revealed that sublethal doses of cinobufagin suppressed the viability of cancer cells by inducing oxidative stress, leading to DNA damage and cell cycle regulation that ultimately resulted in the induction of apoptosis.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Sanchari Dasgupta, Kanisha Kar, Atish Barua, Diya Ghosh, Bikash Kabi, Koushik Dewan, Arpita Chandra
Summary: A novel cobalt complex 1 exhibits significant anticancer activity with lower toxicity compared to oxaliplatin against MCF-7 cells, and shows no significant toxicity to the host. This complex has the potential to be a new chemotherapeutic agent for anti-tumor medication.
Article
Oncology
Fuyan Xu, Huizhi Xi, Mengya Liao, Yiqian Zhang, Hongbo Ma, Mengling Wu, Qiang Xue, Hongbao Sun, Yiwen Zhang, Yong Xia
Summary: Chlorpromazine effectively suppresses colorectal cancer by inducing cell cycle arrest and apoptosis. It also inhibits autophagic flux and induces cytotoxic autophagy in cancer cells. Furthermore, it suppresses tumor growth in mouse models and has no effect on the proportions of immune cells.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huan Liu, Wenchao Zhang, Lijie Jin, Shasha Liu, Liying Liang, Yanfei Wei
Summary: This study investigates the anticancer mechanism of Plumbagin (PLB) and its potential connections with oxidative stress, genotoxicity, and cell cycle arrest. The results indicate that PLB significantly inhibits HCC cell viability and colony formation, induces G2/M cell cycle arrest, oxidative stress, and DNA damage. These effects can be attenuated by NAC pretreatment. PLB triggers a DNA damage response by activating ATM, Chk1, Chk2, and p53. Furthermore, the key modulator of the G2/M transition factor, cdc25C, is downregulated in an ROS-dependent manner. Inhibition of the ATM-p53 pathway can reduce the occurrence of G2/M cell cycle arrest. Therefore, ROS-mediated oxidative stress plays a crucial role in PLB-induced G2/M cell cycle arrest mediated by the ATM-p53 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Guang-Zhe Ge, Hou-Jun Xia, Bao-Li He, Hai-Lin Zhang, Wen-Jing Liu, Ming Shao, Chun-Yan Wang, Ji Xiao, Fei Ge, Fu-Bing Li, Yi Li, Ceshi Chen
INTERNATIONAL JOURNAL OF CANCER
(2016)
Article
Multidisciplinary Sciences
Junying Qin, Zhongmei Zhou, Wenlin Chen, Chunyan Wang, Hailin Zhang, Guangzhe Ge, Ming Shao, Dingyun You, Zhixiang Fan, Houjun Xia, Rong Liu, Ceshi Chen
NATURE COMMUNICATIONS
(2015)
Article
Immunology
Lin-Tao Zhang, Ren-Rong Tian, Hong-Yi Zheng, Guo-Qing Pan, Xiao-Yu Tuo, Hou-Jun Xia, Xue-Shan Xia, Wei Pang, Yong-Tang Zheng
Article
Medicine, Research & Experimental
Liang Guo, Peng Zhang, Zhimin Chen, Houjun Xia, Siming Li, Yanqiao Zhang, Sune Kobberup, Weiping Zou, Jiandie D. Lin
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Cell Biology
Wei Li, Takashi Tanikawa, Ilona Kryczek, Houjun Xia, Gaopeng Li, Ke Wu, Shuang Wei, Lili Zhao, Linda Vatan, Bo Wen, Pan Shu, Duxin Sun, Celina Kleer, Max Wicha, Michael Sabel, Kaixiong Tao, Guobin Wang, Weiping Zou
Article
Medicine, Research & Experimental
Fubing Li, Yang Li, Huichun Liang, Tao Xu, Yanjie Kong, Maobo Huang, Ji Xiao, Xi Chen, Houjun Xia, Yingying Wu, Zhongmei Zhou, Xiaomin Guo, Chunmiao Hu, Chuanyu Yang, Xu Cheng, Ceshi Chen, Xiaopeng Qi
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Multidisciplinary Sciences
Weimin Wang, Michael Green, Jae Eun Choi, Miguel Gijon, Paul D. Kennedy, Jeffrey K. Johnson, Peng Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gaopeng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, Wei Gu, Rebecca Liu, Theodore S. Lawrence, Candice Lamb, Yuri Tanno, Marcin Cieslik, Everett Stone, George Georgiou, Timothy A. Chan, Arul Chinnaiyan, Weiping Zou
Article
Medicine, Research & Experimental
Houjun Xia, Shasha Li, Xiong Li, Weichao Wang, Yingjie Bian, Shuang Wei, Sara Grove, Weimin Wang, Linda Vatan, J. Rebecca Liu, Karen McLean, Ramandeep Rattan, Adnan Munkarah, Jun-Lin Guan, Ilona Kryczek, Weiping Zou
Article
Multidisciplinary Sciences
Yingjie Bian, Wei Li, Daniel M. Kremer, Peter Sajjakulnukit, Shasha Li, Joel Crespo, Zeribe C. Nwosu, Li Zhang, Arkadiusz Czerwonka, Anna Pawlowska, Houjun Xia, Jing Li, Peng Liao, Jiali Yu, Linda Vatan, Wojciech Szeliga, Shuang Wei, Sara Grove, J. Rebecca Liu, Karen McLean, Marcin Cieslik, Arul M. Chinnaiyan, Witold Zgodzinski, Grzegorz Wallner, Iwona Wertel, Karolina Okla, Ilona Kryczek, Costas A. Lyssiotis, Weiping Zou
Article
Oncology
Heng Lin, Ilona Kryczek, Shasha Li, Michael D. Green, Alicia Ali, Reema Hamasha, Shuang Wei, Linda Vatan, Wojciech Szeliga, Sara Grove, Xiong Li, Jing Li, Weichao Wang, Yijian Yan, Jae Eun Choi, Gaopeng Li, Yingjie Bian, Ying Xu, Jiajia Zhou, Jiali Yu, Houjun Xia, Weimin Wang, Ajjai Alva, Arul M. Chinnaiyan, Marcin Cieslik, Weiping Zou
Summary: Immunotherapy can induce durable clinical responses in some cancer patients, but resistance poses a major challenge. The expression of tumor STC1 is correlated with immunotherapy efficacy and negatively associated with patient survival across different cancer types. This study suggests that tumor STC1 may inhibit APC phagocytosis and contribute to tumor immune evasion and immunotherapy resistance.
Review
Cell Biology
Yu Zhang, Dongyun Ouyang, Youhai H. Chen, Houjun Xia
Summary: Macrophages in the peritoneum play crucial roles in controlling immune response and influencing the efficacy of anti-tumor therapy. Research on peritoneal resident macrophages may benefit the development of targeted treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fubing Li, Huichun Liang, Hua You, Ji Xiao, Houjun Xia, Xi Chen, Maobo Huang, Zhuo Cheng, Chuanyu Yang, Wenjing Liu, Hailin Zhang, Li Zeng, Yingying Wu, Fei Ge, Zhen Li, Wenhui Zhou, Yi Wen, Zhongmei Zhou, Rong Liu, Dewei Jiang, Ni Xie, Bin Liang, Zhenzhen Liu, Yanjie Kong, Ceshi Chen
Summary: Metastasis is a major cause of cancer-related deaths. Surgical trauma and inflammation promote tumor cell metastasis. This study reveals that deficiency of HECTD3 reduces tumor metastasis by inhibiting tumor cell adhesion to endothelial cells.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Oncology
Houjun Xia, Douglas R. Green, Weiping Zou
Summary: Autophagy plays a crucial role in cancer by influencing tumor progression, immune responses, and therapy outcomes. Modulating the autophagy pathway can enhance antitumor immune responses and improve treatment efficacy.
NATURE REVIEWS CANCER
(2021)
Article
Immunology
Houjun Xia, Wei Wang, Joel Crespo, Ilona Kryczek, Wei Li, Shuang Wei, Zhaoqun Bian, Tomasz Maj, Mingxiao He, Rebecca J. Liu, Youwen He, Ramandeep Rattan, Adnan Munkarah, Jun-Lin Guan, Weiping Zou
SCIENCE IMMUNOLOGY
(2017)
Article
Oncology
Ming Shao, Guang-Zhe Ge, Wen-Jing Liu, Ji Xiao, Hou-Jun Xia, Yu Fan, Feng Zhao, Bao-Li He, Ceshi Chen