Review
Biochemistry & Molecular Biology
Hyunjoong Kim, Jihye Jung, Sungeon Park, Younglan Joo, Sangbong Lee, Jeongu Sim, Jinhyeong Choi, Hyun Lee, Gyujeong Hwang, Seungwon Lee
Summary: This systematic review synthesized and quantified the changes in fibroblast growth factor-21 (FGF-21) induced by exercise. Through searching and analysis of 10 studies with 376 participants, it was found that FGF-21 levels significantly increased after exercise compared to no exercise. The results suggest that chronic exercise leads to higher FGF-21 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xiaoru Hu, Zhengwei Ma, Siyao Li, Lu Wen, Yuqing Huo, Guangyu Wu, Santhakumar Manicassamy, Zheng Dong
Summary: Kidney repair after injury involves the interaction between injured kidney tubules, interstitial fibroblasts, and immune cells. In this study, the induction of fibroblast growth factor 2 (FGF2) was detected in mouse kidneys and renal tubule cells treated with repeated low-dose cisplatin (RLDC). RLDC treatment led to increased FGF2 expression and secretion, promoting fibroblast proliferation and the expression of fibrosis-related proteins. FGF2 deficiency partially prevented RLDC-induced kidney dysfunction, fibrosis, and inflammation in mice. These findings highlight the important role of FGF2 as a paracrine factor in maladaptive kidney repair and disease progression.
LABORATORY INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Ramy Alam, Yara Mrad, Hussein Hammoud, Zahraa Saker, Youssef Fares, Elias Estephan, Hisham F. Bahmad, Hayat Harati, Sanaa Nabha
Summary: Alzheimer's disease is the leading cause of dementia in the elderly, with characteristic pathological features such as senile plaque formation, neurofibrillary tangles, and synaptic loss. Studies suggest that fibroblast growth factors play important roles in the pathogenesis of AD.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yu Ran Na, Jin Young Kim, Chang Ho Song, Mikyung Kim, Yen Thi Do, Tam Thuy Lu Vo, Eunsom Choi, Eunyoung Ha, Ji Hae Seo, So-Jin Shin
Summary: This study demonstrated the promising antitumor effects of AZD4547 in ovarian cancer cells, including inhibition of proliferation, induction of apoptosis, suppression of migration and invasion, reduction of stem cell activity and angiogenesis, as well as inhibition of in vivo tumor growth in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xu Zhou, Ruth A. Franklin, Miri Adler, Trevor S. Carter, Emily Condiff, Taylor S. Adams, Scott D. Pope, Naomi H. Philip, Matthew L. Meizlish, Naftali Kaminski, Ruslan Medzhitov
Summary: This article reports on the mechanisms controlling the population numbers of different cell types in animal tissues. The study shows that fibroblasts are limited in proliferation due to space availability, while macrophages are constrained by growth factor availability. The transcriptional coactivator YAP1 in fibroblasts directly regulates the expression of the macrophage-specific growth factor Csf1. The findings suggest that tissue environment sensing is a general strategy for controlling tissue composition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nutrition & Dietetics
Mehmet Kanbay, Begum Guler, Lale A. Ertuglu, Tuncay Dagel, Baris Afsar, Said Incir, Arzu Baygul, Adrian Covic, Ana Andres-Hernando, Laura Gabriela Sanchez-Lozada, Miguel A. Lanaspa, Richard J. Johnson
Summary: The study found that fast ingestion of 100% apple juice causes a significantly greater metabolic response, which may be associated with negative long-term outcomes. Therefore, the rate of ingestion must be considered when evaluating the metabolic impacts of sweetened beverage consumption.
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo, Xiuyuan Hao
Summary: This study investigated the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results showed that CS patients had increased FGF23 mRNA levels in the peripheral blood and decreased bone mineral density. Additionally, FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo
Summary: The study investigates the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results show that CS patients have increased peripheral blood FGF23 mRNA levels and decreased bone mineral density, suggesting that FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Review
Endocrinology & Metabolism
Tarana Arman, Peter S. Nelson
Summary: Prostate cancer, including uncommon tumor types with neuroendocrine cell features, is influenced by therapeutic repression of the androgen receptor signaling program. Immunohistochemical staining can identify neuroendocrine tumors, which can impact tumor progression and therapeutic response.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Tokarzewicz, Lukasz Oldak, Grzegorz Mlynarczyk, Urszula Klekotka, Ewa Gorodkiewicz
Summary: A new biosensor based on surface plasmon resonance imaging (SPRi) detection technique has been developed for quantifying fibroblast growth factor 23 (FGF23). The biosensor showed acceptable precision, accuracy, and selectivity, with a wide linear response range and low limits of detection and quantification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Haijun Wang, Jie Yang, Ke Zhang, Jia Liu, Yushan Li, Wei Su, Na Song
Summary: Hepatocellular carcinoma (HCC) is a primary liver cancer with increasing incidence and mortality rates globally. The FGF/FGFR signaling axis has been shown to play an important role in HCC development, and targeted therapies are currently being developed to inhibit this pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Leah R. Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim
Summary: This study aimed to develop stable formulations of FGF-2 using pharmaceutical excipients to withstand physical stressors encountered in processing and storage. Formulations containing MC and alanine (F5) or MC and HSA (F6) were the most effective in stabilizing FGF-2 against thermal and processing stressors. These stabilized solutions have potential applications in medicinal products or in more advanced forms for wound healing and tissue regeneration.
Review
Biochemistry & Molecular Biology
Yue Sui, Jianping Chen
Summary: Fibroblast growth factor 21 (FGF21) is a unique member of the FGF family with special endocrine properties. It has been extensively studied for its physiological functions in response to dietary manipulation, pharmacological benefits in improving macronutrient metabolism, and clinical values as a biomarker of various human diseases. This review focuses on the molecular biology of endocrine FGF21, particularly its regulation of circulating levels and emerging roles in inter-organ crosstalk and cancer development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Sevgi Onal, Merve Turker-Burhan, Gizem Bati-Ayaz, Hamdullah Yanik, Devrim Pesen-Okvur
Summary: The study found that macrophages exhibited chemotaxis towards BCC while BCC required direct contact to interact with macrophage-derived EGF. The interaction between breast cancer cells and macrophages is proposed to be a paracrine-juxtacrine loop involving CSF-1 and EGF, respectively.
Review
Genetics & Heredity
Allen Zinkle, Moosa Mohammadi
FRONTIERS IN GENETICS
(2019)
Article
Biochemistry & Molecular Biology
William M. Marsiglia, Joseph Katigbak, Sijin Zheng, Moosa Mohammadi, Yingkai Zhang, Nathaniel J. Traasethl
Article
Biochemistry & Molecular Biology
Lingfeng Chen, William M. Marsiglia, Huaibin Chen, Joseph Katigbak, Hediye Erdjument-Bromage, David J. Kemble, Lili Fu, Jinghong Ma, Gongqin Sun, Yingkai Zhang, Guang Liang, Thomas A. Neubert, Xiaokun Li, Nathaniel J. Traaseth, Moosa Mohammadi
NATURE CHEMICAL BIOLOGY
(2020)
Article
Hematology
Rafiou Agoro, Min Young Park, Carole Le Henaff, Stanislovas Jankauskas, Alina Gaias, Gaozhi Chen, Moosa Mohammadi, Despina Sitara
Summary: Hypoferremia is an acute response to infection and inflammation, regulated by hepcidin and erythroferrone, while FGF23 may play a key role in contributing to hypoferremia and inhibiting its activity may alleviate LPS-induced hypoferremia. The study showed that inhibiting FGF23 signaling can reduce LPS-induced hepatic and circulating hepcidin levels, leading to alleviation of iron sequestration and improvement in serum iron and transferrin saturation.
Article
Multidisciplinary Sciences
Farnaz Shamsi, Ruidan Xue, Tian Lian Huang, Morten Lundh, Yang Liu, Luiz O. Leiria, Matthew D. Lynes, Elena Kempf, Chih-Hao Wang, Satoru Sugimoto, Pasquale Nigro, Kathrin Landgraf, Tim Schulz, Yiming Li, Brice Emanuelli, Srinivas Kothakota, Lewis T. Williams, Niels Jessen, Steen Bonlokke Pedersen, Yvonne Boettcher, Matthias Blueher, Antje Koerner, Laurie J. Goodyear, Moosa Mohammadi, C. Ronald Kahn, Yu-Hua Tseng
NATURE COMMUNICATIONS
(2020)
Article
Gastroenterology & Hepatology
Qian Lin, Zhifeng Huang, Genxiang Cai, Xia Fan, Xiaoqing Yan, Zhengshuai Liu, Zehua Zhao, Jingya Li, Jia Li, Hongxue Shi, Maiying Kong, Ming-Hua Zheng, Daniel J. Conklin, Paul N. Epstein, Kupper A. Wintergerst, Moosa Mohammadi, Lu Cai, Xiaokun Li, Yu Li, Yi Tan
Summary: The study demonstrated that FGF1(oHBS) is effective in preventing and reversing liver steatosis and steatohepatitis by activating AMPK through hepatocyte FGFR4.
Review
Rheumatology
Yangli Xie, Allen Zinkle, Lin Chen, Moosa Mohammadi
NATURE REVIEWS RHEUMATOLOGY
(2020)
Article
Oncology
Alice Domenichini, Ilaria Casari, Peter V. Simpson, Nima Maheshkumar Desai, Lingfeng Chen, Christopher Dustin, Jeanne S. Edmands, Albert van der Vliet, Moosa Mohammadi, Massimiliano Massi, Marco Falasca
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Junya Wada, Udumbara Rathnayake, Lisa M. Jenkins, Avinash Singh, Moosa Mohammadi, Ettore Appella, Paul A. Randazzo, Lawrence E. Samelson
Summary: Activation of T cells involves various events including phosphorylation and recruitment of proteins to the plasma membrane. This study investigates the recruitment and activation of phospholipase-C gamma 1 (PLC-gamma 1) in T cell activation. The findings suggest that recruitment of PLC-gamma 1 to phosphorylated LAT, formation of the LAT-Gads-SLP-76-PLC-gamma 1 complex, and tyrosine phosphorylation of PLC-gamma 1 regulate its recruitment to liposomes and activation. The study also proposes that these cooperative steps lead to conformational changes in PLC-gamma 1, enabling its interaction with the membrane and enzymatic activity for T cell activation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Lei Ying, Luyao Wang, Kaiwen Guo, Yushu Hou, Na Li, Shuyi Wang, Xingfeng Liu, Qijin Zhao, Jie Zhou, Longwei Zhao, Jianlou Niu, Chuchu Chen, Lintao Song, Shaocong Hou, Lijuan Kong, Xiaokun Li, Jun Ren, Pingping Li, Moosa Mohammadi, Zhifeng Huang
Summary: This study identifies paracrine FGF4 as an anti-hyperglycemic FGF that targets skeletal muscle to increase the abundance of the glucose transporter GLUT4 on the cell surface. Compared to endocrine FGF21, the paracrine FGF4 shows superior glycemic control in diabetic mice and has anti-inflammatory properties, suggesting its potential for treating type 2 diabetes and related metabolic disorders.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jianlou Niu, Jing Zhao, Jiamin Wu, Guanting Qiao, Junlian Gu, Chuanren Zhou, Qi Li, Lei Ying, Dezhong Wang, Huan Lin, Xiaokun Li, Moosa Mohammadi, Zhifeng Huang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Meeting Abstract
Biophysics
William Marsiglia, Joseph Katigbak, Sijin Zheng, Moosa Mohammadi, Yingkai Zhang, Nate Traaseth
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biophysics
Alida Besch, William Marsiglia, Moosa Mohammadi, Yingkai Zhang, Nate Traaseth
BIOPHYSICAL JOURNAL
(2020)
Article
Medicine, Research & Experimental
Qing He, Lauren T. Shumate, Julia Matthias, Cumhur Aydin, Marc N. Wein, Jordan M. Spatz, Regina Goetz, Moosa Mohammadi, Antonius Plagge, Paola Divieti Pajevic, Murat Bastepe