Long-term consumption of green tea EGCG enhances murine healthspan by mitigating multiple aspects of cellular senescence in mitotic and post-mitotic tissues, gut dysbiosis, and immunosenescence

Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice

(2021) Tatiana Dandolini Saccon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

COX2 regulates senescence secretome composition and senescence surveillance through PGE2

(2021) Susana Gonçalves et al.   Cell Reports

Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology

(2021) Rohit Sharma   BIOGERONTOLOGY

Bioactive food components for managing cellular senescence in aging and disease: A critical appraisal and perspectives

(2021) Rohit Sharma   PharmaNutrition

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

(2020) Ravi Kumar et al.   BIOGERONTOLOGY

Plant Polyphenols Based Second Generation Synbiotics: Emerging Concepts, Challenges and Opportunities

(2020) Rohit Sharma et al.   NUTRITION

Senescence in Post-Mitotic Cells: A Driver of Aging?

(2020) Thomas von Zglinicki et al.   ANTIOXIDANTS & REDOX SIGNALING

Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and immunosenescence during aging

(2020) Rohit Sharma et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

(2020) Ping Song et al.   Cells

Decreased autophagy and fuel switching occur in a senescent hepatic cell model system

(2020) Brijesh Kumar Singh et al.   Aging-US

Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control

(2020) Sara Ilari et al.   PHARMACOLOGICAL RESEARCH

Epigallocatechin Gallate Effectively Affects Senescence and Anti-SASP via SIRT3 in 3T3-L1 Preadipocytes in Comparison with Other Bioactive Substances

(2020) Stephanie Lilja et al.   Oxidative Medicine and Cellular Longevity

Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells

(2019) Alcir Luiz Dafre et al.   Oxidative Medicine and Cellular Longevity

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

The role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis

(2019) Alkistis-Maria Papatheodoridi et al.   HEPATOLOGY

Spatio-temporal expression profile of sirtuins during aging of the annual fish Nothobranchius furzeri

(2019) Julijan Kabiljo et al.   GENE EXPRESSION PATTERNS

Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities

(2019) Rohit Sharma et al.   Gut Microbes

Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress

(2018) Marianna Holczer et al.   Oxidative Medicine and Cellular Longevity

Prunus cerasoides fruit extract ameliorates inflammatory stress by modulation of iNOS pathway and Th1/Th2 immune homeostasis in activated murine macrophages and lymphocytes

(2018) Anamika Sharma et al.   INFLAMMOPHARMACOLOGY

Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans

(2018) Li-Gui Xiong et al.   Redox Biology

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway

(2018) Ravi Kumar et al.   BIOGERONTOLOGY

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Restriction Ameliorates Age-Related Increase in DNA Damage, Senescence and Inflammation in Mouse Adipose Tissuey

(2017) A. Ishaq et al.   Journal of Nutrition Health & Aging

Azorella compacta infusion activates human immune cells and scavenges free radicals in vitro

(2017) José Cheel et al.   Pharmacognosy Magazine

A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells

(2017) Lin Zhao et al.   Cell Death & Disease

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

(2016) Christopher D. Wiley et al.   Cell Metabolism

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

“Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes

(2016) Francesco Prattichizzo et al.   Oxidative Medicine and Cellular Longevity

Porcine CD3+NKp46+ Lymphocytes Have NK-Cell Characteristics and Are Present in Increased Frequencies in the Lungs of Influenza-Infected Animals

(2016) Kerstin H. Mair et al.   Frontiers in Immunology

Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B

(2015) Andrew G. Ramstead et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Differential expression of sirtuins in the aging rat brain

(2015) Nady Braidy et al.   Frontiers in Cellular Neuroscience

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases

(2014) Kris Verburgh   AGING CELL

Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers

(2014) Guillermo Mariño et al.   Autophagy

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age-associated inflammation and oxidative stress in healthy rats

(2013) Yucun Niu et al.   AGING CELL

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

(2013) Hae-Suk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

Preventive Effects of Epigallocatechin-3-O-Gallate against Replicative Senescence Associated with p53 Acetylation in Human Dermal Fibroblasts

(2012) Dong-Wook Han et al.   Oxidative Medicine and Cellular Longevity

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Polysaccharides Isolated from Açaí Fruit Induce Innate Immune Responses

(2011) Jeff Holderness et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY