Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.

(2020) Antonella Messore et al.   ACS Medicinal Chemistry Letters

Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

(2020) Angela Corona et al.   Viruses-Basel

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker

(2019) Jing Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus

(2019) Enzo Tramontano et al.   ANTIVIRAL RESEARCH

Discovery of Novel Integrase Inhibitors Acting outside the Active Site Through High-Throughput Screening

(2019) Cindy Aknin et al.   MOLECULES

Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2019) Lei Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3- d ]pyrimidines as kinase inhibitors

(2018) Silvia Salerno et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase

(2018) Paul L. Boyer et al.   JOURNAL OF VIROLOGY

A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other “Shock” Drugs

(2018) Erik Abner et al.   JOURNAL OF VIROLOGY

HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis

(2018) Ravindra K Gupta et al.   LANCET INFECTIOUS DISEASES

Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid

(2018) Lan Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques

(2018) Giosuè Costa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy

(2018) Stephen K Burley et al.   NUCLEIC ACIDS RESEARCH

Synthesis of novel 3,4,6-trisubstituted quinolines enabled by a Gould-Jacobs cyclization

(2017) Stephan Trah et al.   TETRAHEDRON LETTERS

The Stoichiometry of Isoquercitrin Complex with Iron or Copper Is Highly Dependent on Experimental Conditions

(2017) Maria Catapano et al.   Nutrients

New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H

(2016) Angela Corona et al.   ANTIVIRAL RESEARCH

Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors

(2016) Angela Corona et al.   ChemMedChem

Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study

(2016) John Gregson et al.   LANCET INFECTIOUS DISEASES

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors

(2016) Anna Schneider et al.   NUCLEIC ACIDS RESEARCH

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

(2016) Angela Corona et al.   PLoS One

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1

(2015) Mathieu Métifiot et al.   BIOCHIMIE

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Structure–Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

(2015) Giuliana Cuzzucoli Crucitti et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase

(2015) Luca Pescatori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

(2014) Angela Corona et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Foamy Virus Reverse Transcriptase by Human Immunodeficiency Virus Type 1 RNase H Inhibitors

(2014) Angela Corona et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development?

(2014) Angela Corona et al.   Future Virology

Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

(2014) Roberta Costi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

(2014) Sanjeev Kumar V. Vernekar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

(2013) Angela Corona et al.   Future Medicinal Chemistry

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic Acids as Dual Inhibitors of Recombinant HIV-1 Integrase and Ribonuclease H, Synthesized by a Parallel Synthesis Approach

(2013) Roberta Costi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibiting the HIV Integration Process: Past, Present, and the Future

(2013) Roberto Di Santo   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase

(2012) Inna V. Krieger et al.   CHEMISTRY & BIOLOGY

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid andN-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

(2011) Eric B. Lansdon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors

(2011) Fatih Sonmez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diketo Acids Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain

(2011) R. Di Santo   CURRENT MEDICINAL CHEMISTRY

HIV-1 RT-Associated RNase H Function Inhibitors: Recent Advances in Drug Development

(2010) E. Tramontano et al.   CURRENT MEDICINAL CHEMISTRY

Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

(2010) H.-P. Su et al.   JOURNAL OF VIROLOGY

HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors

(2010) Greg L. Beilhartz et al.   Viruses-Basel

Design, synthesis, and biological evaluation of novel quinoline derivatives as HIV-1 Tat–TAR interaction inhibitors

(2009) Shuguang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration

(2009) Christopher J. Lunniss et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities

(2008) Roberto Di Santo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 2. Synthesis and Structure−Activity Relationship of Potent and Selective Cannabinoid-2 Receptor Agonists Endowed with Analgesic Activity in Vivo⊥

(2008) Serena Pasquini et al.   JOURNAL OF MEDICINAL CHEMISTRY