Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase

(2015) Rita Meleddu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis

(2015) Gilberto Betancor et al.   NUCLEIC ACIDS RESEARCH

Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

(2014) Angela Corona et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe

(2014) Dineke Frentz et al.   BMC INFECTIOUS DISEASES

Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development?

(2014) Angela Corona et al.   Future Virology

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

(2014) Sanjeev Kumar V. Vernekar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue

(2013) Brian D. Herman et al.   BIOCHEMICAL JOURNAL

Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors

(2013) Simona Distinto et al.   CURRENT PHARMACEUTICAL DESIGN

Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

(2013) Angela Corona et al.   Future Medicinal Chemistry

Exploiting Drug-Resistant Enzymes as Tools To Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2013) Takashi Masaoka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis

(2013) Mar Álvarez et al.   NUCLEIC ACIDS RESEARCH

Structural Basis of the Allosteric Inhibitor Interaction on the HIV-1 Reverse Transcriptase RNase H Domain

(2012) Martin T. Christen et al.   Chemical Biology & Drug Design

Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach

(2012) Simona Distinto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases

(2011) Francesca Esposito et al.   FEBS Journal

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity

(2011) Suhman Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies

(2011) Anthony K. Felts et al.   Journal of Chemical Information and Modeling

Crystal Structure oftert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket

(2011) Kalyan Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interaction of HIV-1 Reverse Transcriptase Ribonuclease H with an Acylhydrazone Inhibitor

(2010) Qingguo Gong et al.   Chemical Biology & Drug Design

Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

(2010) H.-P. Su et al.   JOURNAL OF VIROLOGY

Conformational Landscape of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Non-Nucleoside Inhibitor Binding Pocket: Lessons for Inhibitor Design from a Cluster Analysis of Many Crystal Structures

(2009) Kristina A. Paris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased Thermostability and Fidelity of DNA Synthesis of Wild-Type and Mutant HIV-1 Group O Reverse Transcriptases

(2009) Mar Álvarez et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

(2009) Daniel M. Himmel et al.   STRUCTURE

The involvement of HIV-1 RNAse H in resistance to nucleoside analogues

(2008) B. Roquebert et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase

(2008) Luis Menéndez-Arias   VIRUS RESEARCH