Cingulin binds to the ZU5 domain of scaffolding protein ZO-1 to promote its extended conformation, stabilization, and tight junction accumulation

PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

(2021) Sophie Sluysmans et al.   MOLECULAR BIOLOGY OF THE CELL

Cell Biology: Tight Junctions as Biomolecular Condensates

(2020) Sandra Citi   CURRENT BIOLOGY

Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics

(2020) Florian Rouaud et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tight Junction Structure and Function Revisited

(2020) Tetsuhisa Otani et al.   TRENDS IN CELL BIOLOGY

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow

(2019) Cornelia Schwayer et al.   CELL

The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo.

(2018) Matthew A Odenwald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK-dependent phosphorylation of cingulin reversibly regulates its binding to actin filaments and microtubules

(2018) Tomoki Yano et al.   Scientific Reports

A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity

(2018) Jimit Shah et al.   Cell Reports

The Claudins: From Tight Junctions to Biological Systems

(2018) Sachiko Tsukita et al.   TRENDS IN BIOCHEMICAL SCIENCES

PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins

(2016) Diego Guerrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells

(2016) Anthony J. Mangan et al.   Nature Communications

ZO Proteins Redundantly Regulate the Transcription Factor DbpA/ZONAB

(2014) Domenica Spadaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer

(2014) Mathieu Unbekandt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The N and C Termini of ZO-1 Are Surrounded by Distinct Proteins and Functional Protein Networks

(2013) Christina M. Van Itallie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium Transport Is Modulated by p38 Kinase-Dependent Cross-Talk between ENaC and Na,K-ATPase in Collecting Duct Principal Cells

(2013) Y.-B. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex

(2012) Sandra Citi et al.   Annals of the New York Academy of Sciences

Distinct Domains of Paracingulin Are Involved in Its Targeting to the Actin Cytoskeleton and Regulation of Apical Junction Assembly

(2012) Serge Paschoud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-Myosin II signaling

(2012) M. Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration

(2011) Lin Huo et al.   EMBO JOURNAL

A Role for ZO-1 and PLEKHA7 in Recruiting Paracingulin to Tight and Adherens Junctions of Epithelial Cells

(2011) Pamela Pulimeno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

PLEKHA7 Is an Adherens Junction Protein with a Tissue Distribution and Subcellular Localization Distinct from ZO-1 and E-Cadherin

(2010) Pamela Pulimeno et al.   PLoS One

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function

(2010) D. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zonula Occludens-1 and -2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions

(2009) Alan S. Fanning et al.   Annals of the New York Academy of Sciences

The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription

(2009) Mei Nie et al.   EMBO REPORTS

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

(2009) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

(2008) Le Shen et al.   JOURNAL OF CELL BIOLOGY

Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells

(2008) Tatsuya Katsuno et al.   MOLECULAR BIOLOGY OF THE CELL