Article
Biochemistry & Molecular Biology
Pingzhou Du, Yu Liu, Lu Deng, Dong Qian, Xiuhua Xue, Ting Yang, Tonghui Li, Yun Xiang, Haiyun Ren
Summary: The newly discovered AtMAC protein is involved in the regulation of phragmoplast organization during centrifugal phragmoplast expansion, playing a crucial role in cytokinesis.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Cell Biology
Shumei Chia, Thomas Leung, Ivan Tan
Summary: LRAP35a plays a crucial role in cell migration by coordinating lamellar contractility and microtubule polarization for efficient directional movement. Its regulation of actomyosin and microtubule networks is tightly controlled by a series of phosphorylation events, influencing the interaction and dissociation of key proteins involved in cellular movement.
Article
Cell Biology
Jorge Ibanez-Vega, Felipe Del Valle, Juan Jose Saez, Fanny Guzman, Jheimmy Diaz, Andrea Soza, Maria Isabel Yuseff
Summary: The study reveals that the asymmetric distribution of the proteasome, mediated by Ecm29, coordinates actin dynamics at the centrosome and the IS in B cells, promoting lysosome recruitment and cell spreading.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Santimoy Sen, Sheetal Lagas, Abhishek Roy, Hemant Kumar
Summary: Cells rely on a balanced cytoskeleton to maintain cellular integrity and regulate signaling pathways. Dysregulation of the cytoskeleton can lead to various pathological conditions, and targeting cytoskeletal dynamics may provide new therapeutic approaches for these diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel A. D. Flormann, Moritz Schu, Emmanuel Terriac, Divyendu Thalla, Lucina Kainka, Marcus Koch, Annica K. B. Gad, Franziska Lautenschlaeger
Summary: Advancements in advanced microscopy techniques have enhanced imaging quality and understanding of subcellular structures, but computational analysis techniques have not progressed at the same pace. A new algorithm for tracing filament networks has been developed, capable of extracting important parameters and distinguishing sub-networks in two-dimensional images. This algorithm can be widely applied in analyzing images obtained from different advanced microscopy methods.
Article
Biochemistry & Molecular Biology
Prasad Vaddepalli, Thijs de Zeeuw, Soeren Strauss, Katharina Buerstenbinder, Che-Yang Liao, Joao Jacob Ramalho, Richard S. Smith, Dolf Weijers
Summary: Premitotic control of cell division orientation is critical for plant development, with formative divisions often producing daughters with different fates. Auxin-dependent division plane control involves alterations in cell geometry by regulating genes controlling cell wall and cytoskeleton properties. This interaction with cell geometry generates asymmetric divisions during the earliest steps in plant development.
Article
Multidisciplinary Sciences
Kaitlin Katsura, Yukiko Nakano, Yan Zhang, Rozana Shemirani, Wu Li, Pamela Den Besten
Summary: Tooth enamel formation is a complex process regulated by multiple differentiation stages and key genes. WDR72, a gene found in various organs, including the teeth, has been discovered to cause enamel defects when deleted or mutated. Unlike other enamel regulation genes, WDR72 functions intracellularly and regulates endocytosis of proteins. The study suggests that WDR72 plays a role in microtubule assembly and directs membrane mobilization and vesicle transport, providing insights into tissue mineralization.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Jianyan Zeng, Jing Xi, Baoxia Li, Xingying Yan, Yonglu Dai, Yiping Wu, Yuehua Xiao, Yan Pei, Mi Zhang
Summary: This study elucidates the roles of actin and microtubule cytoskeletons in the initiation of cotton fiber growth. Both cytoskeletons align along the growth axis in initiating fibers. Dense and bundled actin filaments (AFs) are observed in fiber cells, while microtubules (MTs) are randomized. Pharmacological experiments demonstrate that depolymerization of both AFs and MTs assist fiber initiation, while AF stabilization and depolymerization inhibit elongation. Notably, the organization of AFs is correlated with MT dynamics.
PLANT CELL REPORTS
(2022)
Article
Neurosciences
Congwei Wang, Marco Terrigno, Juan Li, Tania Distler, Nikhil J. Pandya, Martin Ebeling, Stefka Tyanova, Jeroen J. M. Hoozemans, Anke A. Dijkstra, Luisa Fuchs, Shengqi Xiang, Azad Bonni, Fiona Grueuroninger, Ravi Jagasia
Summary: RNA-binding protein G3BP2 interacts with Tau and inhibits Tau aggregation, serving as a line of defense against tauopathies.
Article
Endocrinology & Metabolism
Prajna Udupa, Abhishek Kumar, Rahul Parit, Debasish Kumar Ghosh
Summary: The human diazepam-binding inhibitor (DBI) inhibits autophagy initiation by binding to phosphatidylethanolamine under nutrient-rich conditions and triggers autophagy initiation by releasing phosphorylated DBI under nutrient-deficient conditions.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Chemistry, Multidisciplinary
Ondrej Kucera, Jeremie Gaillard, Christophe Guerin, Clothilde Utzschneider, Manuel Thery, Laurent Blanchoin
Summary: This study investigates the interaction between gliding microtubules and networks of actin filaments, showing that the behavior of microtubules depends on the actin architecture. Unbranched actin networks can effectively guide microtubules during gliding.
Article
Neurosciences
Cristopher Villablanca, Rene Vidal, Christian Gonzalez-Billault
Summary: Astrocytes in the Central Nervous System (CNS) play important roles in both normal functioning and disease. Aging leads to reactive astrogliosis and cellular senescence in astrocytes, resulting in harmful proinflammatory effects. The changes in the cytoskeleton of astrocytes, which have not been extensively studied, may contribute to these alterations associated with aging and pathologies.
BRAIN RESEARCH BULLETIN
(2023)
Editorial Material
Plant Sciences
Huanquan Zheng
Summary: This commentary explores how the ER mediates actin and microtubule dynamics in plant cells, highlighting the role of the ER in cytoskeletal dynamics.
JOURNAL OF PLANT PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Guilherme G. Moreira, Francois-Xavier Cantrelle, Andrea Quezada, Filipa S. Carvalho, Joana S. Cristovao, Urmi Sengupta, Nicha Puangmalai, Ana P. Carapeto, Mario S. Rodrigues, Isabel Cardoso, Guenter Fritz, Federico Herrera, Rakez Kayed, Isabelle Landrieu, Claudio M. Gomes
Summary: The study demonstrates that S100B protein acts as an extracellular chaperone for Tau, inhibiting its aggregation and providing evidence for neuro-protective functions.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Kodai Fukumoto, Yuya Miyazono, Takuya Ueda, Yoshie Harada, Hisashi Tadakuma
Summary: Cellular transport systems are complex and efficient, and there is a need to design artificial transport systems using nanotechnology. However, the design principles have been difficult to establish due to the lack of understanding on how motor layout affects motile activity. In this study, a DNA origami platform was used to evaluate the effect of motor protein layout on transporter motility. The densely packed layout of kinesin motor protein was found to decrease the run length of the transporter, highlighting the importance of considering steric hindrance in transport system design.
NANOSCALE ADVANCES
(2023)
Article
Cell Biology
Junya Kirima, Kazuhiro Oiwa
CELL STRUCTURE AND FUNCTION
(2018)
Correction
Multidisciplinary Sciences
Tomoki Yano, Takayuki Torisawa, Kazuhiro Oiwa, Sachiko Tsukita
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Ryota Ibusuki, Misaki Shiraga, Akane Furuta, Maki Yoshio, Hiroaki Kojima, Kazuhiro Oiwa, Ken'ya Furuta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Taikopaul Kaneko, Ken'ya Furuta, Kazuhiro Oiwa, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa
Review
Biochemistry & Molecular Biology
Kenta Ishibashi, Hitoshi Sakakibara, Kazuhiro Oiwa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Sampreeth Thayyil, Yukinori Nishigami, Md Jahirul Islam, P. K. Hashim, Ken'ya Furuta, Kazuhiro Oiwa, Jian Yu, Min Yao, Toshiyuki Nakagaki, Nobuyuki Tamaoki
Summary: In this study, we developed azobenzene-based photoswitchable ATP antagonists to control the activity of motor proteins cytoplasmic and axonemal dyneins. Our ATP antagonists showed reversible photoswitching of cytoplasmic dynein activity and regulated axonemal dynein motor activity in a force generation model.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Multidisciplinary Sciences
Ryota Ibusuki, Tatsuya Morishita, Akane Furuta, Shintaro Nakayama, Maki Yoshio, Hiroaki Kojima, Kazuhiro Oiwa, Ken'ya Furuta
Summary: This study developed a new protein and DNA-based system for intracellular transport, which can be used for multiplexed cargo transport and control on DNA nanotubes. This technology is expected to have significant applications in the future.
Article
Chemistry, Multidisciplinary
Isabella Guido, Andrej Vilfan, Kenta Ishibashi, Hitoshi Sakakibara, Misaki Shiraga, Eberhard Bodenschatz, Ramin Golestanian, Kazuhiro Oiwa
Summary: This study reports the bottom-up engineering of a sustained beating nanoscale machine capable of mimicking ciliary beating and achieving fluid transport, using a pair of microtubules connected by axonemal dynein.
Article
Chemistry, Multidisciplinary
Hiroki Sakuta, Naoki Nakatani, Takayuki Torisawa, Yutaka Sumino, Kanta Tsumoto, Kazuhiro Oiwa, Kenichi Yoshikawa
Summary: Water phase separation in cells can lead to mechanical motion by entrapping protein motors and generating vortex flow inside cell-sized droplets. This study reveals that the water phase separation interface can drive translational motion of droplets by spontaneously entrapping kinesins and microtubules and generating vortex flow. The findings highlight the importance of water phase separation in both chemical and mechanical processes.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Syeda Rubaiya Nasrin, Tanjina Afrin, Arif Rashedul Md Kabir, Daisuke Inoue, Takayuki Torisawa, Kazuhiro Oiwa, Kazuki Sada, Akira Kakugo
ACS APPLIED BIO MATERIALS
(2020)
Article
Physics, Fluids & Plasmas
Sakurako Tanida, Ken'ya Furuta, Kaori Nishikawa, Tetsuya Hiraiwa, Hiroaki Kojima, Kazuhiro Oiwa, Masaki Sano
Article
Materials Science, Biomaterials
Hideaki Yamamoto, Leroy Grob, Takuma Sumi, Kazuhiro Oiwa, Ayumi Hirano-Iwata, Bernhard Wolfrum
ADVANCED BIOSYSTEMS
(2019)
Article
Chemistry, Multidisciplinary
Taikopaul Kaneko, Suguru Ando, Ken'ya Furuta, Kazuhiro Oiwa, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa
Proceedings Paper
Engineering, Electrical & Electronic
Taikopaul Kaneko, Kazushi Sasakura, Ken'ya Furuta, Kazuhiro Oiwa, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa
2017 IEEE 17TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO)
(2017)