The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer

Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

(2013) Koji Ando et al.   JOURNAL OF CELL BIOLOGY

The benzophenanthridine alkaloid chelerythrine binds to DNA by intercalation: Photophysical aspects and thermodynamic results of iminium versus alkanolamine interaction

(2013) Pritha Basu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells

(2013) C.-S. Loo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine

(2012) Gerda Brunhofer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro

(2012) Henry I C Lowe et al.   Cancer Cell International

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

(2012) Nicola Rath et al.   EMBO REPORTS

ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression

(2012) Bo Rafn et al.   MOLECULAR CELL

Serine-71 Phosphorylation of Rac1 Modulates Downstream Signaling

(2012) Janett Schwarz et al.   PLoS One

Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration

(2011) Lin Huo et al.   EMBO JOURNAL

Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase

(2011) Ivan Tan et al.   FEBS LETTERS

Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion

(2011) Timo Heikkila et al.   PLoS One

A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma

(2010) S. Balasenthil et al.   Cancer Prevention Research

Prognostic Biomarkers for Esophageal Adenocarcinoma Identified by Analysis of Tumor Transcriptome

(2010) Soo Mi Kim et al.   PLoS One

Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles

(2009) C. Gally et al.   DEVELOPMENT

MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices

(2009) Kevin E. Fisher et al.   JOURNAL OF CELL SCIENCE

Non-muscle myosin II takes centre stage in cell adhesion and migration

(2009) Miguel Vicente-Manzanares et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of dystrophia myotonica protein kinase

(2009) Jonathan M. Elkins et al.   PROTEIN SCIENCE

TiGER: a database for tissue-specific gene expression and regulation

(2008) Xiong Liu et al.   BMC BIOINFORMATICS

A Tripartite Complex Containing MRCK Modulates Lamellar Actomyosin Retrograde Flow

(2008) Ivan Tan et al.   CELL

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Applications for ROCK kinase inhibition

(2008) Michael F Olson   CURRENT OPINION IN CELL BIOLOGY

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

(2008) Sung Hee Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

(2008) Dirk A. Heerding et al.   JOURNAL OF MEDICINAL CHEMISTRY