Intracellular localization of the proteasome in response to stress conditions

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PA28γ: New Insights on an Ancient Proteasome Activator

(2021) Paolo Cascio   Biomolecules

Ubiquitin protein helps cells to recover from stress

(2021) Titus Franzmann et al.   NATURE

p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin–proteasome system

(2021) Afu Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitination is essential for recovery of cellular activities after heat shock

(2021) Brian A. Maxwell et al.   SCIENCE

Formation of Non-Nucleoplasmic Proteasome Foci during the Late Stage of Hyperosmotic Stress

(2021) Jeeyoung Lee et al.   Cells

AKIRIN2 controls the nuclear import of proteasomes in vertebrates

(2021) Melanie de Almeida et al.   NATURE

Nuclear pores dilate and constrict in cellulo

(2021) Christian E. Zimmerli et al.   SCIENCE

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

(2021) Aixin Song et al.   eLife

Microautophagy regulates proteasome homeostasis

(2020) Jianhui Li et al.   CURRENT GENETICS

The Sts1 nuclear import adaptor uses a noncanonical bipartite NLS and is directly degraded by the proteasome

(2020) Lauren Budenholzer et al.   JOURNAL OF CELL SCIENCE

The Cellular Location of Rad23, a Polyubiquitin Chain-Binding Protein, Plays a Key Role in its Interaction with Substrates of the Proteasome

(2020) Evelyn Okeke et al.   JOURNAL OF MOLECULAR BIOLOGY

Stress- and ubiquitylation-dependent phase separation of the proteasome

(2020) Sayaka Yasuda et al.   NATURE

Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures

(2020) Hongxin Guan et al.   PLOS BIOLOGY

Reporter-Based Screens for the Ubiquitin/Proteasome System

(2020) Maria E. Gierisch et al.   Frontiers in Chemistry

Deubiquitination Reactions on the Proteasome for Proteasome Versatility

(2020) Ji Yeong Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular and cellular dynamics of the 26S proteasome

(2020) Eri Sakata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mechanisms of substrate recognition by the 26S proteasome

(2020) Caroline Davis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

(2019) Blake W Tye et al.   eLife

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

(2019) Laura Mediani et al.   EMBO JOURNAL

Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes

(2019) Ana Toste Rêgo et al.   MOLECULAR CELL

AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation

(2019) Jianhui Li et al.   PLoS Genetics

Direct visualization of degradation microcompartments at the ER membrane

(2019) Sahradha Albert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment

(2018) Qiang Guo et al.   CELL

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation

(2018) Daxiao Sun et al.   CELL RESEARCH

p62 filaments capture and present ubiquitinated cargos for autophagy

(2018) Gabriele Zaffagnini et al.   EMBO JOURNAL

Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions

(2018) Thuy P. Dao et al.   MOLECULAR CELL

Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome

(2018) Kapil V. Ramachandran et al.   MOLECULAR CELL

Nuclear export of ubiquitinated proteins via the UBIN-POST system

(2018) Shoshiro Hirayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

(2018) Richard S Marshall et al.   eLife

Multiple Modes of Protein–Protein Interactions Promote RNP Granule Assembly

(2018) Tanja Mittag et al.   JOURNAL OF MOLECULAR BIOLOGY

Phase Separation in Biology and Disease

(2018) Julie D. Forman-Kay et al.   JOURNAL OF MOLECULAR BIOLOGY

The cryo-electron microscopy structure of huntingtin

(2018) Qiang Guo et al.   NATURE

Studying Spatial Protein Quality Control, Proteopathies, and Aging Using Different Model Misfolding Proteins in S. cerevisiae

(2018) Kara L. Schneider et al.   Frontiers in Molecular Neuroscience

Specific Modification of Aged Proteasomes Revealed by Tag-Exchangeable Knock-In Mice

(2018) Takuya Tomita et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4

(2017) Antonia A. Nemec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

(2017) Xiaorong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast

(2017) Zhu Chao Gu et al.   MOLECULAR BIOLOGY OF THE CELL

An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome

(2017) Evan J. Worden et al.   MOLECULAR CELL

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

(2017) Kapil V Ramachandran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

(2017) Kapil V Ramachandran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

(2016) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

(2016) Y. Shi et al.   SCIENCE

A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

(2016) Matthias Christoph Munder et al.   eLife

Structural characterization of the interaction of Ubp6 with the 26S proteasome

(2015) Antje Aufderheide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

(2015) Oren Moscovitz et al.   MOLECULAR CELL

Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome

(2014) Chan-Gi Pack et al.   Nature Communications

Proteasome dynamics

(2013) Cordula Enenkel   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ubiquitin-independent proteasomal degradation

(2013) Jenny Erales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Backbone 1H, 13C, and 15N assignments of yeast Ump1, an intrinsically disordered protein that functions as a proteasome assembly chaperone

(2013) Yoshinori Uekusa et al.   Biomolecular NMR Assignments

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

(2013) Sae-Hun Park et al.   CELL

Blm10 facilitates nuclear import of proteasome core particles

(2013) Marion H Weberruss et al.   EMBO JOURNAL

Formation and dissociation of proteasome storage granules are regulated by cytosolic pH

(2013) Lee Zeev Peters et al.   JOURNAL OF CELL BIOLOGY

Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains

(2013) Rui Hao et al.   MOLECULAR CELL

Molecular regulation of stem cell quiescence

(2013) Tom H. Cheung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrity of the Saccharomyces cerevisiae Rpn11 Protein Is Critical for Formation of Proteasome Storage Granules (PSG) and Survival in Stationary Phase

(2013) Rémy Saunier et al.   PLoS One

BIOCHEMICAL AND BIOPHYSICAL CHARACTERIZATION OF RECOMBINANT YEAST PROTEASOME MATURATION FACTOR UMP1

(2013) Bebiana Sá-Moura et al.   Computational and Structural Biotechnology Journal

Quantitative Analysis of Fission Yeast Transcriptomes and Proteomes in Proliferating and Quiescent Cells

(2012) Samuel Marguerat et al.   CELL

The Ubiquitin-Proteasome System of Saccharomyces cerevisiae

(2012) D. Finley et al.   GENETICS

Spg5 Protein Regulates the Proteasome in Quiescence

(2012) John Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation

(2012) Nitzan Shabek et al.   MOLECULAR CELL

Molecular mechanisms of spatial protein quality control

(2012) Simon Alberti   Prion

Loss of a 20S Proteasome Activator in Saccharomyces cerevisiae Downregulates Genes Important for Genomic Integrity, Increases DNA Damage, and Selectively Sensitizes Cells to Agents With Diverse Mechanisms of Action

(2012) Kevin M. Doherty et al.   G3-Genes Genomes Genetics

The Cdc48 machine in endoplasmic reticulum associated protein degradation

(2011) Dieter H. Wolf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural Defects in the Regulatory Particle-Core Particle Interface of the Proteasome Induce a Novel Proteasome Stress Response

(2011) Soyeon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic status rather than cell cycle signals control quiescence entry and exit

(2011) Damien Laporte et al.   JOURNAL OF CELL BIOLOGY

Illuminating the ubiquitin/proteasome system

(2010) Florian A. Salomons et al.   EXPERIMENTAL CELL RESEARCH

Sts1 Plays a Key Role in Targeting Proteasomes to the Nucleus

(2010) Li Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Nucleus-based Quality Control Mechanism for Cytosolic Proteins

(2010) Rupali Prasad et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate Opening

(2010) Kianoush Sadre-Bazzaz et al.   MOLECULAR CELL

Ecm29 Fulfils Quality Control Functions in Proteasome Assembly

(2010) Andrea Lehmann et al.   MOLECULAR CELL

The nanny model for IDPs

(2009) Peter Tsvetkov et al.   Nature Chemical Biology

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversible cytoplasmic localization of the proteasome in quiescent yeast cells

(2008) Damien Laporte et al.   JOURNAL OF CELL BIOLOGY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE