Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

PML nuclear bodies: from architecture to function

(2018) Valérie Lallemand-Breitenbach et al.   CURRENT OPINION IN CELL BIOLOGY

Quality Control of Membraneless Organelles

(2018) Simon Alberti et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications

(2018) Ruth Chia et al.   LANCET NEUROLOGY

mRNA Translation Gone Awry: Translation Fidelity and Neurological Disease

(2018) Mridu Kapur et al.   TRENDS IN GENETICS

Stress-Induced Low Complexity RNA Activates Physiological Amyloidogenesis

(2018) Miling Wang et al.   Cell Reports

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

C9orf72 expansion disrupts ATM-mediated chromosomal break repair

(2017) Callum Walker et al.   NATURE NEUROSCIENCE

Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response

(2017) Adi Ben Yehuda et al.   PLoS One

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

(2016) Kyung-Ha Lee et al.   CELL

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Adaptation to Stressors by Systemic Protein Amyloidogenesis

(2016) Timothy E. Audas et al.   DEVELOPMENTAL CELL

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

(2016) Massimo Ganassi et al.   MOLECULAR CELL

Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

(2016) Petra Schwertman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress

(2016) K Chroma et al.   ONCOGENE

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

(2015) Tina Thorslund et al.   NATURE

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

(2015) Brian D. Freibaum et al.   NATURE

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

How the Nucleus Copes with Proteotoxic Stress

(2014) Yoko Shibata et al.   CURRENT BIOLOGY

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

Most Human Proteins Made in Both Nucleus and Cytoplasm Turn Over within Minutes

(2014) Sabyasachi Baboo et al.   PLoS One

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

(2014) I. Kwon et al.   SCIENCE

Ribosome Profiling Reveals Pervasive Translation Outside of Annotated Protein-Coding Genes

(2014) Nicholas T. Ingolia et al.   Cell Reports

Ubiquitin-independent proteasomal degradation

(2013) Jenny Erales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Environmental cues induce a long noncoding RNA–dependent remodeling of the nucleolus

(2013) Mathieu D. Jacob et al.   MOLECULAR BIOLOGY OF THE CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

SIRT2 directs the replication stress response through CDK9 deacetylation

(2013) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

(2013) Prajwal Ciryam et al.   Cell Reports

The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress

(2013) Erika Shor et al.   PLoS Genetics

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

(2012) Kylie M. Wagstaff et al.   BIOCHEMICAL JOURNAL

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA

(2012) Timothy E. Audas et al.   MOLECULAR CELL

The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication

(2011) Alexandra Deichsel et al.   CELL CYCLE

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

(2011) Mayura Meerang et al.   NATURE CELL BIOLOGY

TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97

(2010) G. P. Ritson et al.   JOURNAL OF NEUROSCIENCE

Characterization and prediction of protein nucleolar localization sequences

(2010) Michelle S. Scott et al.   NUCLEIC ACIDS RESEARCH

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

(2010) L Latonen et al.   ONCOGENE

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

(2009) Y.-J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

(2008) Ina Poser et al.   NATURE METHODS