PACT Establishes a Post-transcriptional Brake on Mitochondrial Biogenesis by Promoting the Maturation of miR-181c

The RNA-binding protein HuR is a negative regulator in adipogenesis

(2020) Diana Teh Chee Siang et al.   Nature Communications

Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress-induced toxicity by miR-181/SIRT1/PGC-1α/Nrf2 signaling pathway in human neuroblastoma SH-SY5Y cells: Implication for association between chlorpyrifos and Parkinson's

(2019) Meng-Wen Zhao et al.   ENVIRONMENTAL TOXICOLOGY

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models

(2019) Alessia Indrieri et al.   EMBO Molecular Medicine

QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity

(2019) Huanyu Lu et al.   EMBO REPORTS

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

(2018) Elahu G. Sustarsic et al.   Cell Metabolism

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

The prevalence of PRKRA mutations in idiopathic dystonia

(2018) Camila Oliveira dos Santos et al.   PARKINSONISM & RELATED DISORDERS

Upregulation of miR-181 Decreases c-Fos and SIRT-1 in the Hippocampus of 3xTg-AD Mice

(2018) Carlos J. Rodriguez-Ortiz et al.   JOURNAL OF ALZHEIMERS DISEASE

PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization

(2017) Pak-Yin Lui et al.   JOURNAL OF IMMUNOLOGY

Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

(2017) Ozlem Tufanli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial homeostasis in adipose tissue remodeling

(2017) Svetlana Altshuler-Keylin et al.   Science Signaling

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT

(2017) Stephanie Dabo et al.   Scientific Reports

Mitochondrial homeostasis in adipose tissue remodeling

(2017) Svetlana Altshuler-Keylin et al.   Science Signaling

MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure

(2017) Farnaz Shamsi et al.   Frontiers in Endocrinology

Metabolic heterogeneity of activated beige/brite adipocytes in inguinal adipose tissue

(2017) Yun-Hee Lee et al.   Scientific Reports

Mitochondrial remodeling: Rearranging, recycling, and reprogramming

(2016) Roberta A. Gottlieb et al.   CELL CALCIUM

Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function

(2016) Matteo Oliverio et al.   NATURE CELL BIOLOGY

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

miR-30 Promotes Thermogenesis and the Development of Beige Fat by Targeting RIP140

(2015) Fang Hu et al.   DIABETES

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1  signaling network

(2015) H. Zhang et al.   EMBO REPORTS

Brown adipose tissue: physiological function and evolutionary significance

(2015) R. Oelkrug et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis

(2015) Ross C. Wilson et al.   MOLECULAR CELL

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

(2014) Deborah M. Muoio   CELL

KSRP Ablation Enhances Brown Fat Gene Program in White Adipose Tissue Through Reduced miR-150 Expression

(2014) C.-F. Chou et al.   DIABETES

Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

(2014) Emilio P. Mottillo et al.   JOURNAL OF LIPID RESEARCH

The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing

(2013) Lukas Stalder et al.   EMBO JOURNAL

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

MiR-27 orchestrates the transcriptional regulation of brown adipogenesis

(2013) Lei Sun et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

(2013) Ho Young Lee et al.   NUCLEIC ACIDS RESEARCH

Multiple sensors ensure guide strand selection in human RNAi pathways

(2013) C. L. Noland et al.   RNA

MicroRNA networks regulate development of brown adipocytes

(2013) Mirko Trajkovski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

miR-133a Regulates Adipocyte Browning In Vivo

(2013) Weiyi Liu et al.   PLoS Genetics

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Nuclear miRNA Regulates the Mitochondrial Genome in the Heart

(2012) Samarjit Das et al.   CIRCULATION RESEARCH

Increased interaction between PACT molecules in response to stress signals is required for PKR activation

(2012) Madhurima Singh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Sam68 STAR RNA-Binding Protein Regulates mTOR Alternative Splicing during Adipogenesis

(2012) Marc-Étienne Huot et al.   MOLECULAR CELL

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis

(2011) Jussi Pihlajamäki et al.   Cell Metabolism

siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes

(2011) Cameron L. Noland et al.   MOLECULAR CELL

The Role of Dicer Protein Partners in the Processing of MicroRNA Precursors

(2011) Edyta Koscianska et al.   PLoS One

Substrate-Specific Kinetics of Dicer-Catalyzed RNA Processing

(2010) Srinivas Chakravarthy et al.   JOURNAL OF MOLECULAR BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding

(2009) Tomoko Kawamata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Essential Role of PACT-Mediated PKR Activation in Tunicamycin-Induced Apoptosis

(2008) Madhurima Singh et al.   JOURNAL OF MOLECULAR BIOLOGY

DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA

(2008) Sarah Camargos et al.   LANCET NEUROLOGY

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS