Prenatal Hypoxia Affects Foetal Cardiovascular Regulatory Mechanisms in a Sex- and Circadian-Dependent Manner: A Review

Placental blood flow sensing and regulation in fetal growth restriction

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Feto-Maternal Crosstalk in the Development of the Circadian Clock System

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Rhythm of fetoplacental 11β-hydroxysteroid dehydrogenase type 2 – fetal protection from morning maternal glucocorticoids

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Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early‐onset gestational hypoxia

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Intrapartal cardiotocographic patterns and hypoxia-related perinatal outcomes in pregnancies complicated by gestational diabetes mellitus

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Passively inhaled tobacco smoke - pregnancy and neonatal outcomes in correlation with placental histopathology

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Gestational Intermittent Hypoxia Induces Sex-Specific Impairment in Endothelial Mechanisms and Sex Steroid Hormone Levels in Male Rat Offspring

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Glycolysis under Circadian Control

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Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver

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Programming effects of maternal stress on the circadian system of adult offspring

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Circadian clock gene Clock is involved in the pathogenesis of preeclampsia through hypoxia

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Out of Breath, Out of Time: Interactions between HIF and Circadian Rhythms

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Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults

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Critical period regulation across multiple timescales

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Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia

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Altered Cardiovascular Defense to Hypotensive Stress in the Chronically Hypoxic Fetus

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Animal models of human pregnancy and placentation: alternatives to the mouse

(2020) Anthony M Carter   REPRODUCTION

Intrauterine growth restriction: Clinical consequences on health and disease at adulthood

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Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction

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Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress

(2019) Xueyi Chen et al.   HYPERTENSION RESEARCH

Intervention against hypertension in the next generation programmed by developmental hypoxia

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Pre-eclampsia: pathogenesis, novel diagnostics and therapies

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Circadian rhythms and the molecular clock in cardiovascular biology and disease

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Development and Entrainment of the Fetal Clock in the Suprachiasmatic Nuclei: The Role of Glucocorticoids

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Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia

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The Physiology of Intrapartum Fetal Compromise at Term

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Melatonin attenuates renal sympathetic overactivity and reactive oxygen species in the brain in neurogenic hypertension

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Placental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea

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Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction

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Glucocorticoid Maturation of Fetal Cardiovascular Function

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Circadian control of lung inflammation in influenza infection

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Gestational Hypoxia and Programing of Lung Metabolism

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Indoor light pollution and progression of carotid atherosclerosis: A longitudinal study of the HEIJO-KYO cohort

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Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment

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Multi-Omics Integration Reveals Short and Long-Term Effects of Gestational Hypoxia on the Heart Development

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Maternal exercise, season and sex modify the daily fetal heart rate rhythm

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Sex differences in maternal gestational hypertension-induced sensitization of angiotensin II hypertension in rat offspring: the protective effect of estrogen

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Obstructive Sleep Apnea in Pregnant Women

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Asthma Outcomes and Management During Pregnancy

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Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism

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Maternal Congenital Heart Disease in Pregnancy

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Maternal treatment with a placental-targeted antioxidant (MitoQ) impacts offspring cardiovascular function in a rat model of prenatal hypoxia

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Maternal sleep during pregnancy and poor fetal outcomes: A scoping review of the literature with meta-analysis

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Placental adaptation to early-onset hypoxic pregnancy and mitochondria-targeted antioxidant therapy in rat

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Prenatal hypoxia impairs cardiac mitochondrial and ventricular function in guinea pig offspring in a sex-related manner

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Synchronization and maintenance of circadian timing in the mammalian clockwork

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A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes

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Feto- and utero-placental vascular adaptations to chronic maternal hypoxia in the mouse

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Placental peptides metabolism and maternal factors as predictors of risk of gestational diabetes in pregnant women. A case-control study

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Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heart

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Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restriction

(2017) Kimberley C.W. Wang et al.   RESPIROLOGY

Prenatal Hypoxia Induced Dysfunction in Cerebral Arteries of Offspring Rats

(2017) Jiaqi Tang et al.   Journal of the American Heart Association

Gestational hypoxia disrupts the neonatal leptin surge and programs hyperphagia and obesity in male offspring in the Sprague-Dawley rat

(2017) Vladimir E. Vargas et al.   PLoS One

Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner

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Cardiac output and related haemodynamics during pregnancy: a series of meta-analyses

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Chronic Blockade of the Androgen Receptor Abolishes Age-Dependent Increases in Blood Pressure in Female Growth-Restricted RatsNovelty and Signficance

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Prenatal hypoxia in rats increased blood pressure and sympathetic drive of the adult offspring

(2016) Pavel Svitok et al.   HYPERTENSION RESEARCH

Pregnancy-induced adaptations of the central circadian clock and maternal glucocorticoids

(2016) Michaela D Wharfe et al.   JOURNAL OF ENDOCRINOLOGY

The fetal brain sparing response to hypoxia: physiological mechanisms

(2016) Dino A. Giussani   JOURNAL OF PHYSIOLOGY-LONDON

Hypoxia-inducible factor-1α, vascular endothelial growth factor, inducible nitric oxide synthase, and endothelin-1 expression correlates with angiogenesis in congenital heart disease

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Placental Origins of Chronic Disease

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Prenatal hypoxia enhanced angiotensin II-mediated vasoconstriction via increased oxidative signaling in fetal rats

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Human fetal growth restriction: a cardiovascular journey through to adolescence

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Estrogen Regulates Angiotensin II Receptor Expression Patterns and Protects the Heart from Ischemic Injury in Female Rats1

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Inappropriate Neural Activity during a Sensitive Period in Embryogenesis Results in Persistent Seizure-like Behavior

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Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea

(2015) Gregg L. Semenza et al.   JOURNAL OF APPLIED PHYSIOLOGY

Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy

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Late gestational hypoxia and a postnatal high salt diet programs endothelial dysfunction and arterial stiffness in adult mouse offspring

(2015) Sarah L. Walton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo

(2015) Nozomi Itani et al.   JOURNAL OF PINEAL RESEARCH

Melatonin modulates the fetal cardiovascular defense response to acute hypoxia

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Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: Interactions with placental renin-angiotensin system

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Iron Deficiency Anemia in Pregnancy

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Effects of Antenatal Hypoxia on Tissue Homeostasis in the Myocardium of Albino Rats: Early and Delayed Consequences

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Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease

(2014) Ali Balci et al.   HEART

Prenatal Hypoxia Leads to Increased Muscle Sympathetic Nerve Activity, Sympathetic Hyperinnervation, Premature Blunting of Neuropeptide Y Signaling, and Hypertension in Adult Life

(2014) William Rook et al.   HYPERTENSION

Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner

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Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs

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Antenatal Hypoxia Induces Programming of Reduced Arterial Blood Pressure Response in Female Rat Offspring: Role of Ovarian Function

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Innate Immune System and Preeclampsia

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Effect of maternal chronic intermittent hypoxia during gestation on offspring growth in the rat

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Vitamin C Prevents Intrauterine Programming of in vivo Cardiovascular Dysfunction in the Rat

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Anemia in Pregnancy

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Prenatal Hypoxia Causes Long-Term Alterations in Vascular Endothelin-1 Function in Aged Male, but Not Female, Offspring

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Hypoxia-Inducible Factor-1α in Vascular Smooth Muscle Regulates Blood Pressure Homeostasis Through a Peroxisome Proliferator–Activated Receptor-γ–Angiotensin II Receptor Type 1 Axis

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Gestational Hypoxia Induces Preeclampsia-Like Symptoms via Heightened Endothelin-1 Signaling in Pregnant Rats

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Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction

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Intermittent maternal hypoxia has an influence on regional expression of endothelial nitric oxide synthase in fetal arteries of rabbits

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Placental Hypoxia and Foetal Development Versus Alcohol Exposure in Pregnancy

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Morphometric Characteristics of Terminal Villi of the Placenta in Pre-Eclampsia

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Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents

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Endothelin-1 induces hypoxia inducible factor 1α expression in pulmonary artery smooth muscle cells

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Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats

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Maternal High-Fat Diet Disturbs Uteroplacental Hemodynamics and Increases the Frequency of Stillbirth in a Nonhuman Primate Model of Excess Nutrition

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Silencing of Hypoxia-Inducible Factor-1α Gene Attenuated Angiotensin II–Induced Renal Injury in Sprague-Dawley Rats

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Morphological and Functional Alterations in the Aorta of the Chronically Hypoxic Fetal Rat

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Antioxidant Defenses in the Rat Placenta in Late Gestation: Increased Labyrinthine Expression of Superoxide Dismutases, Glutathione Peroxidase 3, and Uncoupling Protein 21

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Chronic Prenatal Hypoxia Induces Epigenetic Programming of PKCε Gene Repression in Rat Hearts

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Hypoglycemia and the Origin of Hypoxia-Induced Reduction in Human Fetal Growth

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Changes of Renal AT1/AT2Receptors and Structures in Ovine Fetuses following Exposure to Long-Term Hypoxia

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Hypoxia during pregnancy in rats leads to early morphological changes of atherosclerosis in adult offspring

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Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth

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Effects of gestational diabetes on fetal oxygen and glucose levels in vivo

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Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats

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Placental metabolic reprogramming: do changes in the mix of energy-generating substrates modulate fetal growth?

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The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia

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Prenatal Hypoxia Causes a Sex-Dependent Increase in Heart Susceptibility to Ischemia and Reperfusion Injury in Adult Male Offspring: Role of Protein Kinase C 

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Developmental change of T-type Ca2+channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia

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Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

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Prenatal hypoxia preconditioning improves hypoxic ventilatory response and reduces mortality in neonatal rats

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