期刊
PROGRESS IN NEUROBIOLOGY
卷 87, 期 4, 页码 252-263出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2008.12.001
关键词
Renin-angiotensin system; Fetal brain; Development
资金
- National Natural Science Foundation [30570915, 30871400]
- Jiangsu Natural Science Key Grant [BK2006703]
- Jiangsu High Education Natural Science Foundation [08KJB320013]
- Suzhou Key Lab Grant [SZS0602]
- Suzhou Social Development Research Grant [SS08018, SS08045]
- Suzhou International Scientific Cooperation Grant [N2134703]
- Suda Medical Key Grant [EE 134704]
- Soochow University Program Project Grant [90134602]
Since the concept of fetal origins of adult diseases was introduced in 1980s, the development of the renin-angiotensin system (RAS) in normal and abnormal patterns has attracted attention. Recent studies have shown the importance of the fetal RAS in both prenatal and postnatal development. This review focuses on the functional development of the fetal brain RAS, and ontogeny of local brain RAS components in utero. The central RAS plays an important role in the control of fetal cardiovascular responses, body fluid balance, and neuroendocrine regulation. Recent progress has been made in demonstrating that altered fetal RAS development as a consequence of environmental insults may impact on programming of hypertension later in life. Given that the central RAS is of equal importance to the peripheral RAS in cardiovascular regulation, studies on the fetal brain RAS development in normal and abnormal patterns Could shed light on programming mechanisms of adult cardiovascular diseases in fetal origins. (C) 2009 Elsevier Ltd. All rights reserved
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