期刊
ENVIRONMENT INTERNATIONAL
卷 133, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2019.105184
关键词
Indoor light pollution; Carotid atherosclerosis; Circadian rhythm; Light at night; Bedroom
资金
- Department of Indoor Environmental Medicine, Nara Medical University, Japan
- JSPS KAKENHI, Japan [24790774, 22790567, 25860447, 25461393, 15H04776, 10124877]
- Mitsui Sumitomo Insurance Welfare Foundation, Japan
- Meiji Yasuda Life Foundation of Health and Welfare, Japan
- Osaka Gas Group Welfare Foundation, Japan
- Japan Diabetes Foundation, Japan
- Daiwa Securities Health Foundation, Japan
- Japan Science and Technology Agency, Japan
- YKK AP Inc., Japan
- Ushio Inc., Japan
- Nara Prefecture Health Promotion Foundation, Japan
- Nara Medical University
- Tokyo Electric Power Company, Japan
- EnviroLife Research Institute Co., Ltd., Japan
- Sekisui Chemical Co., Ltd, Japan
- LIXIL Corp., Japan
- KYOCERA Corp, Japan
Exposure to light at inappropriate times in relation to the solar cycle can disturb circadian endocrine and metabolic rhythms. Previous studies have suggested an association between light exposure at night (LAN) and obesity, an important risk factor of atherosclerosis, although it remains unclear whether LAN associates with progression of atherosclerosis. To evaluate the longitudinal association between bedroom LAN intensity and progression of carotid atherosclerosis, light intensity in the bedroom at baseline and carotid artery intima-media thickness (IMT) at baseline and follow-up were measured in 989 elderly participants (945 at baseline and 780 at a median follow-up time of 34 months). The mean age of the participants was 71.4 +/- 6.9 years. The average mean and maximal carotid IMT at baseline were 0.88 +/- 0.15 and 1.10 +/- 0.32 mm, respectively. The median intensity of bedroom LAN was 0.68 lx (IQR, 0.07-3.29). In multivariable analysis adjusted for potential confounders, the highest LAN group exhibited a significant increase in mean carotid IMT (adjusted beta, 0.028; 95% CI, 0.005-0.052; P = 0.019) compared with the lowest LAN quartile group. A similar relationship was found between LAN and maximal carotid IMT (adjusted beta, 0.083; 95% CI, 0.037-0.129; P < 0.001). In conclusion, we found a clear and significant association between bedroom LAN intensity and progression of subclinical carotid atherosclerosis, which was independent of known risk factors for atherosclerosis, including age, obesity, smoking, economic status, hypertension, and diabetes. Indoor light pollution may be a potential risk factor for atherosclerosis in the general population.
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