Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Review
Biochemistry & Molecular Biology
Georgina Gonzalez-Avila, Bettina Sommer, Edgar Flores-Soto, Arnoldo Aquino-Galvez
Summary: The tumor microenvironment (TME) is characterized by acidic pH and low oxygen concentrations. Hypoxia induces tumor cells to evade immune surveillance, repair DNA, reprogram metabolism, and metastasize, mainly through hypoxia-inducible factors (HIFs). Additionally, cancer cells increase the expression of matrix metalloproteinases (MMPs) in response to TME conditions, enabling migration to different tissues. This review focuses on the expression of MMPs in normal and hypoxic conditions, considering the role of HIFs and other transcription factors. Strategies targeting MMPs alone or in combination with other therapies are also discussed, given the resistance to conventional anticancer treatments caused by the hypoxic TME.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Milosz Caban, Katarzyna Owczarek, Urszula Lewandowska
Summary: Eye diseases are linked to visual impairment and reduced quality of life. Current treatments for these diseases are not satisfactory, highlighting the need for new therapeutic approaches. Matrix metalloproteinases and tissue inhibitors of metalloproteinases play crucial roles in eye diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Rohit Siddhartha, Minal Garg
Summary: MMPs are a group of enzymes that play a crucial role in degrading proteins in the extracellular matrix and regulating cell signaling. Dysregulation of MMPs can lead to serious pathological conditions such as inflammation, uncontrolled cell growth, and cancer metastasis. Understanding the functions of MMPs has potential implications for cancer diagnosis, prognosis, and therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Christian Behm, Michael Nemec, Fabian Weissinger, Marco Aoqi Rausch, Oleh Andrukhov, Erwin Jonke
Summary: The systematic review revealed that orthodontic forces induce increased expression levels of MMPs and TIMPs in the PDL during orthodontic tooth movement. However, the exact effect may vary depending on intervention and sample parameters as well as subject characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Cansu Kaya, Jelena Konstantinovic, Andreas M. Kany, Anastasia Andreas, Jan S. Kramer, Steffen Brunst, Lilia Weizel, Marco J. Rotter, Denia Frank, Samir Yahiaoui, Rolf Mueller, Rolf W. Hartmann, Joerg Haupenthal, Ewgenij Proschak, Thomas A. Wichelhaus, Anna K. H. Hirsch
Summary: Drug-resistant pathogens pose a global challenge to public health, and metallo-beta-lactamases (MBLs) are enzymes that catalyze the hydrolysis of beta-lactam drugs, including carbapenems. We have identified a series of inhibitors that effectively inhibit the activity of B1 MBLs, restoring the effectiveness of current beta-lactam antibiotics. In experiments, one of the inhibitors significantly reduced the minimum inhibitory concentration of resistant Escherichia coli strains, and the combination with imipenem also increased the survival rate of infected larvae in a model.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Richard J. R. Kelwick, Alexander J. Webb, Yizhou Wang, Amelie Heliot, Fiona Allan, Aidan M. Emery, Michael R. Templeton, Paul S. Freemont
Summary: The ALPHA beads, containing a library of low-cost, biodegradable protease biosensors utilizing PhaC-reporter fusion proteins, can detect specific proteases in various samples and have the potential for use in resource-limited settings.
Article
Physiology
Hong Song, Brian M. Polster, Loren P. Thompson
Summary: Intrauterine hypoxia alters the mitochondrial phenotype in fetal hearts, disrupting the expression and activities of select complexes and potentially reducing respiratory efficiency. This disruption is predominantly seen in male fetal hearts, affecting cardiac metabolism and predisposing offspring to heart dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Lorena Cayetano-Salazar, Dania A. Nava-Tapia, Kevin D. Astudillo-Justo, Adan Arizmendi-Izazaga, Cesar Sotelo-Leyva, Mayra Herrera-Martinez, Socrates Villegas-Comonfort, Napoleon Navarro-Tito
Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.
Article
Chemistry, Analytical
Shuo Yin, Aipeng Chen, Xiaoni Fang, Peng Zhang, Chaoyong Yang
Summary: This article introduces a method for simultaneous detection of MMP14 expression and MMP14 proteolytic activity using a fluorescent nanosensor based on a spherical aptamer/peptide dual-probe strategy. The proposed sensor outperforms traditional methods in terms of analytical performances, and has successfully been applied for the detection of exosomal MMP14 from cell culture media and real serum samples. The increased levels of MMP14 expression and proteolytic activity in serum from cancer patients indicate the potential of this method as biomarkers in liquid biopsy for disease diagnosis and real-time surveillance.
Article
Biochemistry & Molecular Biology
Monika Skrzypiec-Spring, Agnieszka Sapa-Wojciechowska, Alina Rak-Pasikowska, Maciej Kaczorowski, Iwona Bil-Lula, Agnieszka Halon, Adam Szelag
Summary: This study investigated the inhibitory effect of simvastatin, a Rho-associated protein kinase (RhoA/ROCK) signaling pathway inhibitor, on matrix metalloproteinase 2 (MMP-2) activity in a rat ischemia-reperfusion injury (I/Ri) model. The results showed that simvastatin improved the contractile function of the heart and reduced MMP-2 activity in heart tissue by inhibiting the RhoA/ROCK pathway. The protective effect of simvastatin on systolic function in the acute ischemia-reperfusion model is not related to reduced MMP-2 activation but is mediated through other mechanisms associated with RhoA/ROCK pathway inhibition.
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Desiree Napolitano, Pasquale Mastroroberto, Umberto Marcello Bracale, Michele Andreucci, Raffaele Serra
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic condition characterized by altered collagen turnover of the extracellular matrix. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are abnormally released in patients with HCM. This systematic review found that MMP levels, particularly MMP2, were higher in HCM patients compared to healthy subjects. MMPs can be used as biomarkers for HCM and for monitoring treatment outcomes.
Article
Biochemistry & Molecular Biology
Aneta Choreziak-Michalak, Dawid Szpecht, Anna Chmielarz-Czarnocinska, Agnieszka Seremak-Mrozikiewicz, Krzysztof Drews, Grazyna Kurzawinska, Ewa Strauss, Anna Gotz-Wieckowska
Summary: This study investigates the relationship between genetic variations in matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) and the development of retinopathy of prematurity (ROP) in the Polish population. The results suggest that certain genetic variants, including the MMP-1 rs179975 1G deletion allele and TIMP-1 rs4898C allele, are associated with an increased risk of ROP. The study also identifies interactions between multiple genetic loci that impact the risk of ROP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Umberto Bracale, Roberto Peltrini, Biancamaria Iacone, Mirko Martirani, Daniele Sannino, Antonio Gargiulo, Francesco Corcione, Raffaele Serra, Umberto Marcello Bracale
Summary: This study aimed to investigate the relationship between extracellular matrix disorders and abdominal wall hernias (AWHs) and the levels of matrix metalloproteinases (MMPs). The results showed that AWHs may be a disease of the extracellular matrix, supported by increased levels of MMPs in patients with AWHs. The study also highlighted the impact of tissue inhibitors of metalloproteinases (TIMPs) on AWHs. More prospective studies are needed to confirm the relationship between these biomarkers and the risk of AWHs.
Review
Biochemistry & Molecular Biology
Stephan Niland, Johannes A. Eble
Summary: The tumor microenvironment (TME) is a key focus in cancer research and treatment, involving various components including ECM and modifying enzymes. Cells within the TME interact with the ECM, influencing tumor progression through feedback mechanisms involving cellular receptors, cytokines, and exosomes. Matrix remodeling in the TME, particularly by matrix metalloproteinases (MMPs), plays a crucial role in modifying ECM barriers and releasing soluble ECM fragments that impact cells both within and outside the TME.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Lei Huang, Xin Chen, Chiranjib Dasgupta, Wanqiu Chen, Rui Song, Charles Wang, Lubo Zhang
CARDIOVASCULAR RESEARCH
(2019)
Article
Peripheral Vascular Disease
Xiang-Qun Hu, Rui Song, Monica Romero, Chiranjib Dasgupta, Xiaohui Huang, Mark A. Holguin, VaShon Williams, Daliao Xiao, Sean M. Wilson, Lubo Zhang
Article
Immunology
Bo Li, Chiranjib Dasgupta, Lei Huang, Xianmei Meng, Lubo Zhang
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Cell Biology
Sebastien Bonnet, Olivier Boucherat, Roxane Paulin, Danchen Wu, Charles C. T. Hindmarch, Stephen L. Archer, Rui Song, Joseph B. Moore, Steeve Provencher, Lubo Zhang, Shizuka Uchida
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Rui Song, Xiang-Qun Hu, Monica Romero, Mark A. Holguin, Whitney Kagabo, Daliao Xiao, Sean M. Wilson, Lubo Zhang
Summary: Pregnancy increases the association of BKCa channel subunits and alters the localization of RyR subtypes in uterine arteries. Knockdown of RyR1 or RyR2 decreases Ca2+ sparks and STOCs frequency, increases myogenic tone, while RyR3 knockdown has no significant effect. This study provides new insights into the mechanisms of uterine vascular adaptation to pregnancy through RyR subtypes.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Rui Song, Lubo Zhang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Xiang-Qun Hu, Lubo Zhang
Summary: Hypoxia during gestation has significant impacts on maternal complications and fetal development. Mitochondrial ROS play a key role in placental dysfunction and pregnancy complications. Therapeutic approaches targeting mitochondrial ROS in placental cells are discussed for potential treatment strategies.
Article
Biochemistry & Molecular Biology
Guofang Shen, Shirley Hu, Zhen Zhao, Lubo Zhang, Qingyi Ma
Summary: CNP plays a vascular protective role in neonatal brain injury by reducing brain infarct size, decreasing brain edema and IgG extravasation, and protecting BMECs against oxygen-glucose deprivation. The vasculoprotective effect of CNP is mediated by its innate receptors NPR2 and NPR3, indicating a potential therapeutic target for neonatal brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xiangqun Hu, Lubo Zhang
Summary: During pregnancy, uteroplacental blood flow increases, which is crucial for the well-being of both the mother and the growth/development of the fetus. This hemodynamic change is primarily achieved through uterine vascular adaptation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yajie Tong, Shuqing Zhang, Suzette Riddle, Lubo Zhang, Rui Song, Dongmei Yue
Summary: Intrauterine hypoxia can affect lung cell epigenome, leading to developmental issues and increased risk of diseases in the lungs.
Article
Biochemistry & Molecular Biology
Yong Li, Yanyan Zhang, Andrew Walayat, Yingjie Fu, Bailin Liu, Lubo Zhang, Daliao Xiao
Summary: Nicotine exposure during the perinatal period can induce a sensitive phenotype to neonatal brain hypoxic-ischemic injury in offspring. The H19/miR-181a/ATG5 signaling pathway plays a regulatory role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Taiming Liu, Meijuan Zhang, Avoumia Mourkus, Hobe Schroeder, Lubo Zhang, Gordon G. Power, Arlin B. Blood
Summary: Chronic hypoxia at high altitude alters iron homeostasis and bioactive nitric oxide metabolites (NOx) levels in the fetal circulation. The fetus utilizes iron from non-hematopoietic tissues for erythropoiesis and shows increased bioavailability of NO in response to hypoxic stress at high altitude during gestation.
Article
Biochemistry & Molecular Biology
Eugenia Mata-Greenwood, Hans C. A. Westenburg, Stacy Zamudio, Nicholas P. Illsley, Lubo Zhang
Summary: High-altitude residence negatively impacts vitamin D levels, with Andeans having the lowest 25-OH-D levels and Europeans having the lowest 1 alpha,25-(OH)(2)-D levels. The ratio of 1 alpha,25-(OH)(2)-D to 25-OH-D is significantly lower in Europeans compared to Andeans. Placental gene expression plays a major role in circulating vitamin D levels, and high-altitude residents have a stronger correlation between vitamin D levels and placental gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Andrew J. Patterson, Minwoo A. Song, David Choe, Daliao Xiao, Gary Foster, Lubo Zhang
Article
Biochemistry & Molecular Biology
Peng Zhang, Yong Li, Yingjie Fu, Lei Huang, Bailin Liu, Lubo Zhang, Xuesi M. Shao, Daliao Xiao
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
