Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

(2021) Dongdong Zhang et al.   Journal of Neuroinflammation

DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion

(2021) Muyassar Mamtilahun et al.   Frontiers in Cellular Neuroscience

The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model

(2021) Nicole J. Sylvain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The neuroprotective effect of MicroRNA-149-5p and coenzymeQ10 by reducing levels of inflammatory cytokines and metalloproteinases following focal brain ischemia in rats

(2021) Elham Ghasemloo et al.   BRAIN RESEARCH BULLETIN

Using Rotenone to Model Parkinson’s Disease in Mice: A Review of the Role of Pharmacokinetics

(2021) Jürgen Innos et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease

(2021) Katja Badanjak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model

(2021) Lu Jing et al.   Journal of Inflammation Research

Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis

(2021) Mootaz M Salman et al.   BRAIN

Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis

(2021) Mootaz M. Salman et al.   NATURE REVIEWS NEUROSCIENCE

Cerebral Edema Formation After Stroke: Emphasis on Blood–Brain Barrier and the Lymphatic Drainage System of the Brain

(2021) Sichao Chen et al.   Frontiers in Cellular Neuroscience

Recent breakthroughs and future directions in drugging aquaporins

(2021) Mootaz M. Salman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fenretinide attenuates lipopolysaccharide (LPS)-induced blood-brain barrier (BBB) and depressive-like behavior in mice by targeting Nrf-2 signaling

(2020) Ting Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

(2020) Philip Kitchen et al.   CELL

Integrin CD11b mediates locus coeruleus noradrenergic neurodegeneration in a mouse Parkinson’s disease model

(2020) Liyan Hou et al.   Journal of Neuroinflammation

Iron and inflammation: in vivo and post-mortem studies in Parkinson’s disease

(2020) Antonio Martin-Bastida et al.   JOURNAL OF NEURAL TRANSMISSION

Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance

(2020) Weixi Feng et al.   Alzheimers Research & Therapy

Protocatechuic acid attenuates brain edema and blood-brain barrier disruption after intracerebral hemorrhage in mice by promoting Nrf2/HO-1 pathway

(2020) Zhiyu Xi et al.   NEUROREPORT

NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis

(2019) Liyan Hou et al.   TOXICOLOGY

Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model

(2019) Liyan Hou et al.   Redox Biology

Influence of Matrix Metallopeptidase 9 on Beta-Amyloid Elimination Across the Blood-Brain Barrier

(2019) Ben Shackleton et al.   MOLECULAR NEUROBIOLOGY

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease

(2019) Shirley Yin-Yu Pang et al.   Translational Neurodegeneration

Lanthanum Chloride Impairs the Blood-Brain Barrier Integrity by Reduction of Junctional Proteins and Upregulation of MMP-9 in Rats

(2018) Jie Wu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

(2018) Xiaoxia Yang et al.   FASEB JOURNAL

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Microglia in the Neurovascular Unit: Blood–Brain Barrier–microglia Interactions After Central Nervous System Disorders

(2018) Hannah Thurgur et al.   NEUROSCIENCE

Taurine protects dopaminergic neurons in a mouse Parkinson’s disease model through inhibition of microglial M1 polarization

(2018) Yuning Che et al.   Cell Death & Disease

Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway

(2018) Liyan Hou et al.   Redox Biology

Mild Endoplasmic Reticulum Stress Protects Against Lipopolysaccharide-Induced Astrocytic Activation and Blood-Brain Barrier Hyperpermeability

(2018) Yiwei Wang et al.   Frontiers in Cellular Neuroscience

Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations

(2018) Janos Groh et al.   GLIA

Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model

(2018) Shawn M. Barton et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

(2018) Changjun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

(2017) Yasmina Manso et al.   GLIA

Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study

(2017) Camille Pouchieu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) produces edema due to BBB disruption induced by MMP-9 activation in rat hippocampus

(2017) Mercedes Pérez-Hernández et al.   NEUROPHARMACOLOGY

Tenuigenin down-regulates the release of nitric oxide, matrix metalloproteinase-9 and cytokines from lipopolysaccharide-stimulated microglia

(2017) Li Lu et al.   NEUROSCIENCE LETTERS

Methylmercury Causes Blood-Brain Barrier Damage in Rats via Upregulation of Vascular Endothelial Growth Factor Expression

(2017) Tetsuya Takahashi et al.   PLoS One

Brain Inflammation, Blood Brain Barrier dysfunction and Neuronal Synaptophysin Decrease after Inhalation Exposure to Titanium Dioxide Nano-aerosol in Aging Rats

(2017) Clémence Disdier et al.   Scientific Reports

Parkinson's disease: Autoimmunity and neuroinflammation

(2016) Armando De Virgilio et al.   AUTOIMMUNITY REVIEWS

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

(2016) Ralf G Rempe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

Apigenin protects blood–brain barrier and ameliorates early brain injury by inhibiting TLR4-mediated inflammatory pathway in subarachnoid hemorrhage rats

(2015) Tingting Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

(2013) Felipe Dal-Pizzol et al.   MOLECULAR NEUROBIOLOGY

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

(2012) Qingshan Wang et al.   Journal of Neuroinflammation

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

(2012) Jiankun Cui et al.   Molecular Neurodegeneration

Progesterone and allopregnanolone attenuate blood–brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases

(2010) Tauheed Ishrat et al.   EXPERIMENTAL NEUROLOGY

Alteration of blood brain barrier permeability by T-2 toxin: Role of MMP-9 and inflammatory cytokines

(2010) Jayaraj Ravindran et al.   TOXICOLOGY

Cyclooxygenase-1 and -2 Differentially Modulate Lipopolysaccharide-Induced Blood–Brain Barrier Disruption through Matrix Metalloproteinase Activity

(2009) Saba Aid et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by alpha-synuclein in rat primary glial cells

(2009) So Hyun Joo et al.   NEUROSCIENCE LETTERS