Cerebral Edema Formation After Stroke: Emphasis on Blood–Brain Barrier and the Lymphatic Drainage System of the Brain

The role of glymphatic system in the cerebral edema formation after ischemic stroke

(2021) Caihong Ji et al.   EXPERIMENTAL NEUROLOGY

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Flood of cerebrospinal fluid causes oedema after stroke

(2020) Sarah Lemprière   Nature Reviews Neurology

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

Management of acute ischemic stroke

(2020) Michael S Phipps et al.   BMJ-British Medical Journal

Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

(2020) Lijing Kang et al.   Nature Communications

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage

(2020) Jinman Chen et al.   Nature Communications

Noninvasive Characterization of Human Glymphatics and Meningeal Lymphatics in an in vivo Model of Blood–Brain Barrier Leakage

(2020) Chia‐Hung Wu et al.   ANNALS OF NEUROLOGY

Pituitary Adenylate Cyclase-Activating Polypeptide Attenuates Brain Edema by Protecting Blood–Brain Barrier and Glymphatic System After Subarachnoid Hemorrhage in Rats

(2020) Yuanjian Fang et al.   Neurotherapeutics

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

(2020) Ashley C. Bolte et al.   Nature Communications

Impaired meningeal lymphatic vessel development worsens stroke outcome

(2019) Pavel Yanev et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

(2019) Roxana Aldea et al.   Frontiers in Aging Neuroscience

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

(2019) Ana I. Casas et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebrovascular Injuries Induce Lymphatic Invasion into Brain Parenchyma to Guide Vascular Regeneration in Zebrafish

(2019) Jingying Chen et al.   DEVELOPMENTAL CELL

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

ZIPK mediates endothelial cell contraction through myosin light chain phosphorylation and is required for ischemic-reperfusion injury

(2019) Yiteng Zhang et al.   FASEB JOURNAL

Roles of glial ion transporters in brain diseases

(2019) Shanshan Song et al.   GLIA

The Involvement and Therapy Target of Immune Cells After Ischemic Stroke

(2019) Zhihong Jian et al.   Frontiers in Immunology

Brain-to-cervical lymph node signaling after stroke

(2019) Elga Esposito et al.   Nature Communications

Selective mGluR1 Negative Allosteric Modulator Reduces Blood–Brain Barrier Permeability and Cerebral Edema After Experimental Subarachnoid Hemorrhage

(2019) Cheng Zhang et al.   Translational Stroke Research

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion

(2018) Miki Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exacerbated brain edema in a rat streptozotocin model of hyperglycemic ischemic stroke: Evidence for involvement of blood–brain barrier Na–K–Cl cotransport and Na/H exchange

(2018) Natalie Y Yuen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction

(2018) Joaquim Miguel Vieira et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Meningeal Lymphatics and Cerebrospinal Fluid Outflow

(2018) Rajnish S. Dave et al.   Journal of Neuroimmune Pharmacology

Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke

(2018) Jens P. Dreier et al.   NEUROPHARMACOLOGY

Microglia in the Neurovascular Unit: Blood–Brain Barrier–microglia Interactions After Central Nervous System Disorders

(2018) Hannah Thurgur et al.   NEUROSCIENCE

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases

(2018) Bao-Liang Sun et al.   PROGRESS IN NEUROBIOLOGY

Neurovascular unit transport responses to ischemia and common coexisting conditions: smoking and diabetes

(2018) Ali E Sifat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Selective role of Na+ /H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post-stroke function recovery

(2018) Shanshan Song et al.   GLIA

The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo

(2018) Jacopo Di Lucente et al.   GLIA

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes

(2018) Per Kristian Eide et al.   Scientific Reports

Aquaporins in brain edema

(2018) Tifenn Clément et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Early Prediction of Malignant Brain Edema After Ischemic Stroke

(2018) Simiao Wu et al.   STROKE

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

(2018) Changjun Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Selective knockout of astrocytic Na+ /H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke

(2017) Gulnaz Begum et al.   GLIA

SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling

(2017) Jesse A. Stokum et al.   GLIA

Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways

(2017) Ionica Pirici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing

(2017) Oxana Semyachkina-Glushkovskaya et al.   JOURNAL OF BIOMEDICAL OPTICS

Subarachnoid hemorrhage – Induced block of cerebrospinal fluid flow: Role of brain coagulation factor III (tissue factor)

(2017) Eugene V Golanov et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Development and plasticity of meningeal lymphatic vessels

(2017) Salli Antila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

(2017) Srikant Rangaraju et al.   Journal of Neuroinflammation

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

(2017) Takashi Shichita et al.   NATURE MEDICINE

Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate

(2017) Romain Goulay et al.   STROKE

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

The lymphatic vascular system of the mouse head

(2016) Melanie Lohrberg et al.   CELL AND TISSUE RESEARCH

Tetramethylpyrazine Protects Against Oxygen-Glucose Deprivation-Induced Brain Microvascular Endothelial Cells Injury via Rho/Rho-kinase Signaling Pathway

(2016) Guang Yang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Differential Kv1.3, KCa3.1, and Kir2.1 expression in “classically” and “alternatively” activated microglia

(2016) Hai M. Nguyen et al.   GLIA

Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice

(2016) Lorenz Hirt et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The blood–brain barrier after stroke: Structural studies and the role of transcytotic vesicles

(2016) Michael J Haley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The extracellular matrix protein laminin-10 promotes blood–brain barrier repair after hypoxia and inflammation in vitro

(2016) Korakoch Kangwantas et al.   Journal of Neuroinflammation

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Zinc contributes to acute cerebral ischemia-induced blood–brain barrier disruption

(2016) Zhifeng Qi et al.   NEUROBIOLOGY OF DISEASE

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

(2016) Renée J. Turner et al.   Frontiers in Cellular Neuroscience

Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control

(2016) C Luo et al.   Cell Death & Disease

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow

(2016) Qunwen Pan et al.   Molecular Brain

Cerebral Microvascular Endothelial Cell Apoptosis after Ischemia: Role of Enolase-Phosphatase 1 Activation and Aci-Reductone Dioxygenase 1 Translocation

(2016) Yuan Zhang et al.   Frontiers in Molecular Neuroscience

The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

(2015) Ravi L. Rungta et al.   CELL

Blood−brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

(2015) Roshini Prakash et al.   CURRENT OPINION IN NEUROLOGY

Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies

(2015) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Molecular pathophysiology of cerebral edema

(2015) Jesse A Stokum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ultrastructural analysis of blood–brain barrier breakdown in the peri-infarct zone in young adult and aged mice

(2015) Patrick C Nahirney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System

(2015) B. A. Plog et al.   JOURNAL OF NEUROSCIENCE

Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium

(2015) Keith D. Rochfort et al.   MICROVASCULAR RESEARCH

Migration and Phagocytic Ability of Activated Microglia During Post-natal Development is Mediated by Calcium-Dependent Purinergic Signalling

(2015) Aditya Sunkaria et al.   MOLECULAR NEUROBIOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Cardiac lymphatics are heterogeneous in origin and respond to injury

(2015) Linda Klotz et al.   NATURE

Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia

(2015) Xiaoming Yao et al.   NEUROSCIENCE LETTERS

Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood–brain barrier in vitro

(2015) Takashi Machida et al.   NEUROSCIENCE LETTERS

The role of microglia and myeloid immune cells in acute cerebral ischemia

(2015) Corinne Benakis et al.   Frontiers in Cellular Neuroscience

The central role of aquaporins in the pathophysiology of ischemic stroke

(2015) Jasmine Vella   Frontiers in Cellular Neuroscience

The Ischemic Environment Drives Microglia and Macrophage Function

(2015) Stefano Fumagalli et al.   Frontiers in Neurology

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

Evidence that Meningeal Mast Cells Can Worsen Stroke Pathology in Mice

(2014) Ahmet Arac et al.   AMERICAN JOURNAL OF PATHOLOGY

Ischemic factor-induced increases in cerebral microvascular endothelial cell Na/H exchange activity and abundance: evidence for involvement of ERK1/2 MAP kinase

(2014) Natalie Yuen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Sustained Na+/H+ Exchanger Activation Promotes Gliotransmitter Release from Reactive Hippocampal Astrocytes following Oxygen-Glucose Deprivation

(2014) Pelin Cengiz et al.   PLoS One

Downregulation of Blood-Brain Barrier Phenotype by Proinflammatory Cytokines Involves NADPH Oxidase-Dependent ROS Generation: Consequences for Interendothelial Adherens and Tight Junctions

(2014) Keith D. Rochfort et al.   PLoS One

Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI

(2014) Thomas Gaberel et al.   STROKE

Drowning stars: reassessing the role of astrocytes in brain edema

(2014) Alexander S. Thrane et al.   TRENDS IN NEUROSCIENCES

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke

(2014) Youngjeon Lee et al.   Biomed Research International

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Monocyte chemoattractant protein-1 and the blood–brain barrier

(2013) Yao Yao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

‘Hit & Run’ Model of Closed-Skull Traumatic Brain Injury (TBI) Reveals Complex Patterns of Post-Traumatic AQP4 Dysregulation

(2013) Zeguang Ren et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

Drainage of Cells and Soluble Antigen from the CNS to Regional Lymph Nodes

(2013) Jon D. Laman et al.   Journal of Neuroimmune Pharmacology

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Blood–brain barrier opening to large molecules does not imply blood–brain barrier opening to small ions

(2013) E.J. Kang et al.   NEUROBIOLOGY OF DISEASE

Glibenclamide in Cerebral Ischemia and Stroke

(2013) J. Marc Simard et al.   Neurocritical Care

Effects of Interleukin-6 on the Expression of Tight Junction Proteins in Isolated Cerebral Microvessels from Yearling and Adult Sheep

(2013) Susan S. Cohen et al.   NEUROIMMUNOMODULATION

Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression

(2013) Y. Yoshimatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase

(2013) T. I. Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permanent and Transient Focal Cerebral Ischemia Models

(2012) Wei Zhou et al.   BRAIN PATHOLOGY

Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm

(2012) M.J. Rowland et al.   BRITISH JOURNAL OF ANAESTHESIA

Protein Kinase C  Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor-Induced Permeability In Vivo

(2012) T. Murakami et al.   DIABETES

Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

(2012) Jesus M Pradillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cognitive Deficits and Delayed Neuronal Loss in a Mouse Model of Multiple Microinfarcts

(2012) M. Wang et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Involvement of oxidative stress in hypoxia-induced blood–brain barrier breakdown

(2012) Abraham Al Ahmad et al.   MICROVASCULAR RESEARCH

Relocalization of Junctional Adhesion Molecule A during Inflammatory Stimulation of Brain Endothelial Cells

(2012) S. M. Stamatovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

(2012) Jiankun Cui et al.   Molecular Neurodegeneration

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke

(2012) R. Khatri et al.   NEUROLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Aquaporins in Cerebrovascular Disease: A Target for Treatment of Brain Edema

(2011) J. Badaut et al.   CEREBROVASCULAR DISEASES

Aquaporin-4-dependent edema clearance following status epilepticus

(2011) Darrin J. Lee et al.   EPILEPSY RESEARCH

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

(2011) Rachid Kacimi et al.   Journal of Inflammation-London

Role of sodium/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains

(2011) Yejie Shi et al.   JOURNAL OF NEUROCHEMISTRY

Neutrophil Depletion Reduces Blood-Brain Barrier Breakdown, Axon Injury, and Inflammation After Intracerebral Hemorrhage

(2011) Iska Moxon-Emre et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema

(2010) Yuka Ikegame et al.   HYPERTENSION RESEARCH

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

(2010) Perttu Johannes Lindsberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Water Mobility Decreases after Astrocytic Aquaporin-4 Inhibition Using RNA Interference

(2010) Jérôme Badaut et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide

(2010) Ray Chui et al.   Journal of Neuroinflammation

Activation of Microglia Depends on Na+/H+ Exchange-Mediated H+ Homeostasis

(2010) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

The Na–K–Cl Co-transporter in astrocyte swelling

(2010) Arumugam R. Jayakumar et al.   METABOLIC BRAIN DISEASE

Brain Endothelial Cell Death: Modes, Signaling Pathways, and Relevance to Neural Development, Homeostasis, and Disease

(2010) Maria Teresa Rizzo et al.   MOLECULAR NEUROBIOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

(2010) Hironaka Igarashi et al.   NEUROLOGICAL SCIENCES

Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage

(2010) M.J. Tait et al.   NEUROSCIENCE

Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin

(2009) Tina I. Lam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Bone marrow-derived cells are the major source of MMP-9 contributing to blood–brain barrier dysfunction and infarct formation after ischemic stroke in mice

(2009) Guangming Wang et al.   BRAIN RESEARCH

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolae-mediated Internalization of Occludin and Claudin-5 during CCL2-induced Tight Junction Remodeling in Brain Endothelial Cells

(2009) Svetlana M. Stamatovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Src Activity Decreases Tyrosine Phosphorylation of Occludin in Brain Capillaries and Attenuates Increase in Permeability of the Blood-Brain Barrier after Transient Focal Cerebral Ischemia

(2009) Yuji Takenaga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Malignant middle cerebral artery infarction: clinical characteristics, treatment strategies, and future perspectives

(2009) Hagen B Huttner et al.   LANCET NEUROLOGY

Neutrophil elastase and neurovascular injury following focal stroke and reperfusion

(2009) Ann M. Stowe et al.   NEUROBIOLOGY OF DISEASE

Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: A combined MRI–histological study

(2009) Thomas Tourdias et al.   NEUROIMAGE

Regulation of Endothelial Junctional Permeability

(2008) Emily Vandenbroucke et al.   Annals of the New York Academy of Sciences

Real-time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices andin vivorevealed by two-photon microscopy

(2008) W. Christopher Risher et al.   GLIA

Glial Cell Aquaporin-4 Overexpression in Transgenic Mice Accelerates Cytotoxic Brain Swelling

(2008) Baoxue Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of adherens junctions and VE-cadherin in the control of vascular permeability

(2008) E. Dejana et al.   JOURNAL OF CELL SCIENCE

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS

Protective Effect of Delayed Treatment With Low-Dose Glibenclamide in Three Models of Ischemic Stroke

(2008) J. Marc Simard et al.   STROKE

Aquaporin-4 in Acute Cerebral Edema Produced by Clostridium perfringens Type D Epsilon Toxin

(2008) J. W. Finnie et al.   VETERINARY PATHOLOGY

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology

Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells

(2007) Julien Brillault et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY