Biochemical characterization of actin assembly mechanisms with ALS-associated profilin variants

New twists in actin–microtubule interactions

(2021) Morgan L. Pimm et al.   MOLECULAR BIOLOGY OF THE CELL

Formin Cdc12’s specific actin assembly properties are tailored for cytokinesis in fission yeast

(2021) Kaitlin E. Homa et al.   BIOPHYSICAL JOURNAL

Mechanism of actin filament nucleation

(2021) Aaron D. Rosenbloom et al.   BIOPHYSICAL JOURNAL

Nucleation limits the lengths of actin filaments assembled by formin

(2021) Mark E. Zweifel et al.   BIOPHYSICAL JOURNAL

Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

(2021) Ahmad Shahir Sadr et al.   METABOLIC BRAIN DISEASE

ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization

(2021) Eric J. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profilin Isoforms in Health and Disease – All the Same but Different

(2021) Kai Murk et al.   Frontiers in Cell and Developmental Biology

Competition for delivery of profilin-actin to barbed ends limits the rate of formin-mediated actin filament elongation

(2020) Mark E Zweifel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge

(2020) Kristen Skruber et al.   CURRENT BIOLOGY

Profilin 1 delivery tunes cytoskeletal dynamics toward CNS axon regeneration

(2020) Rita Pinto-Costa et al.   JOURNAL OF CLINICAL INVESTIGATION

Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability

(2019) Guillaume Jacquemet et al.   CURRENT BIOLOGY

Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia crosslinker fascin

(2019) Alyssa J. Harker et al.   MOLECULAR BIOLOGY OF THE CELL

In silico analysis of PFN1 related to amyotrophic lateral sclerosis

(2019) Gabriel Rodrigues Coutinho Pereira et al.   PLoS One

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis

(2019) Anthony Giampetruzzi et al.   Nature Communications

Profilin and formin constitute a pacemaker system for robust actin filament growth

(2019) Johanna Funk et al.   eLife

Reconsidering an active role for G-actin in cytoskeletal regulation

(2018) Kristen Skruber et al.   JOURNAL OF CELL SCIENCE

Modulation of formin processivity by profilin and mechanical tension

(2018) Luyan Cao et al.   eLife

ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation

(2018) Mahmoud Kiaei et al.   Scientific Reports

Gating mechanisms during actin filament elongation by formins

(2018) Fikret Aydin et al.   eLife

A Fluorophore Fusion Construct of Human Profilin I with Non-Compromised Poly(L-Proline) Binding Capacity Suitable for Imaging

(2017) Michaela Nejedla et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly

(2017) Dennis Zimmermann et al.   Nature Communications

Biophysical analysis of three novel profilin-1 variants associated with amyotrophic lateral sclerosis indicates a correlation between their aggregation propensity and the structural features of their globular state

(2016) Edoardo Del Poggetto et al.   BIOLOGICAL CHEMISTRY

Profilin1 biology and its mutation, actin(g) in disease

(2016) Duah Alkam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and Motility

(2016) Julien Pernier et al.   DEVELOPMENTAL CELL

Profilin connects actin assembly with microtubule dynamics

(2016) Michaela Nejedla et al.   MOLECULAR BIOLOGY OF THE CELL

Internetwork competition for monomers governs actin cytoskeleton organization

(2016) Cristian Suarez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome

(2016) Kristin Michaelsen-Preusse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerated actin filament polymerization from microtubule plus ends

(2016) J. L. Henty-Ridilla et al.   SCIENCE

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43

(2016) Liangzhong Lim et al.   PLOS BIOLOGY

Sporadic and hereditary amyotrophic lateral sclerosis (ALS)

(2015) Senda Ajroud-Driss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton

(2015) Axel Freischmidt et al.   BMC NEUROSCIENCE

Profilin-1 mediated cell-cycle arrest: searching for drug targets

(2015) Pierre DJ Moens et al.   CELL CYCLE

Global Resource Distribution: Allocation of Actin Building Blocks by Profilin

(2015) Jessica L. Henty-Ridilla et al.   DEVELOPMENTAL CELL

Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways

(2015) Jeremy D. Rotty et al.   DEVELOPMENTAL CELL

Profilin Regulates F-Actin Network Homeostasis by Favoring Formin over Arp2/3 Complex

(2015) Cristian Suarez et al.   DEVELOPMENTAL CELL

Structural basis for mutation-induced destabilization of profilin 1 in ALS

(2015) Sivakumar Boopathy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics

(2014) M. D. Figley et al.   JOURNAL OF NEUROSCIENCE

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

Interaction of Profilin with the Barbed End of Actin Filaments

(2013) Naomi Courtemanche et al.   BIOCHEMISTRY

Dynamic Localization of G-Actin during Membrane Protrusion in Neuronal Motility

(2013) Chi Wai Lee et al.   CURRENT BIOLOGY

Formins at a glance

(2013) Dennis Breitsprecher et al.   JOURNAL OF CELL SCIENCE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

(2013) Benjamin A Smith et al.   eLife

Determinants of Formin Homology 1 (FH1) Domain Function in Actin Filament Elongation by Formins

(2012) Naomi Courtemanche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Rocket Launcher Mechanism of Collaborative Actin Assembly Defined by Single-Molecule Imaging

(2012) D. Breitsprecher et al.   SCIENCE

Individual Actin Filaments in a Microfluidic Flow Reveal the Mechanism of ATP Hydrolysis and Give Insight Into the Properties of Profilin

(2011) Antoine Jégou et al.   PLOS BIOLOGY

SMN, profilin IIa and plastin 3: A link between the deregulation of actin dynamics and SMA pathogenesis

(2009) Mélissa Bowerman et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Unleashing formins to remodel the actin and microtubule cytoskeletons

(2009) Melissa A. Chesarone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Incompatibility with Formin Cdc12p Prevents Human Profilin from Substituting for Fission Yeast Profilin

(2008) Obidimma C. Ezezika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of the FH1 Domain and Profilin in Formin-Mediated Actin-Filament Elongation and Nucleation

(2007) Aditya Paul et al.   CURRENT BIOLOGY

High-resolution Structural Analysis of Mammalian Profilin 2a Complex Formation with Two Physiological Ligands: The Formin Homology 1 Domain of mDia1 and the Proline-rich Domain of VASP

(2007) Petri Kursula et al.   JOURNAL OF MOLECULAR BIOLOGY