Profilin1 biology and its mutation, actin(g) in disease

Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation

(2016) Yoshinori Tanaka et al.   HUMAN MOLECULAR GENETICS

Neuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome

(2016) Kristin Michaelsen-Preusse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations of Profilin-1 Associated with Amyotrophic Lateral Sclerosis Promote Aggregation Due to Structural Changes of Its Native State

(2015) Edoardo Del Poggetto et al.   ACS Chemical Biology

Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton

(2015) Axel Freischmidt et al.   BMC NEUROSCIENCE

Two independently folding units of Plasmodium profilin suggest evolution via gene fusion

(2015) Saligram Prabhakar Bhargav et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Profilin-1 expression is associated with high grade and stage and decreased disease-free survival in renal cell carcinoma

(2015) Jason R. Karamchandani et al.   HUMAN PATHOLOGY

Novel mutations support a role for Profilin 1 in the pathogenesis of ALS

(2015) Bradley N. Smith et al.   NEUROBIOLOGY OF AGING

Structural basis for mutation-induced destabilization of profilin 1 in ALS

(2015) Sivakumar Boopathy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

(2015) A. C. Woerner et al.   SCIENCE

The Folding process of Human Profilin-1, a novel protein associated with familial amyotrophic lateral sclerosis

(2015) Edoardo Del Poggetto et al.   Scientific Reports

Regulatory roles of phosphoinositides in membrane trafficking and their potential impact on cell-wall synthesis and re-modelling

(2014) Praveen Krishnamoorthy et al.   ANNALS OF BOTANY

C-terminus of Hsc70-interacting protein regulates profilin1 and breast cancer cell migration

(2014) Ye Na Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Profilin 1 is required for peripheral nervous system myelination

(2014) L. Montani et al.   DEVELOPMENT

Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics

(2014) M. D. Figley et al.   JOURNAL OF NEUROSCIENCE

Targeting Axonal Regeneration: The Growth Cone Takes the Lead

(2014) L. Montani et al.   JOURNAL OF NEUROSCIENCE

Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis

(2014) Wantong Yao et al.   Molecular Cancer

Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation

(2014) Yi Fan et al.   NATURE CELL BIOLOGY

Autosomal dominant inheritance of rapidly progressive amyotrophic lateral sclerosis due to a truncation mutation in the fused in sarcoma (FUS) gene

(2014) Louisa Kent et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis

(2014) Ana Catarina Pronto-Laborinho et al.   Biomed Research International

The role of profilin-1 in endothelial cell injury induced by advanced glycation end products (AGEs)

(2013) Zhenyu Li et al.   Cardiovascular Diabetology

Mutation analysis and immunopathological studies of PFN1 in familial and sporadic amyotrophic lateral sclerosis

(2013) Shu Yang et al.   NEUROBIOLOGY OF AGING

PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis

(2013) YongPing Chen et al.   NEUROBIOLOGY OF AGING

Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells

(2013) Jitendra Kumar Kanaujiya et al.   PROTEOMICS

Profilin-1 mutations are rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia

(2013) Marka van Blitterswijk et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

The multifaceted role of profilin-1 in adipose tissue inflammation and glucose homeostasis

(2013) Munkyong Pae et al.   Adipocyte

Neural response to emotional stimuli during experimental human endotoxemia

(2012) Jennifer S. Kullmann et al.   HUMAN BRAIN MAPPING

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Profilin phosphorylation as a VEGFR effector in angiogenesis

(2012) Michael Simons et al.   NATURE CELL BIOLOGY

Stimulus-dependent phosphorylation of profilin-1 in angiogenesis

(2012) Yi Fan et al.   NATURE CELL BIOLOGY

Mutations in the PFN1 gene are not a common cause in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration in France

(2012) Serena Lattante et al.   NEUROBIOLOGY OF AGING

Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and in frontotemporal dementia

(2012) Cinzia Tiloca et al.   NEUROBIOLOGY OF AGING

A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts

(2012) Caroline Ingre et al.   NEUROBIOLOGY OF AGING

Purkinje cell loss and motor coordination defects in profilin1 mutant mice

(2012) J.A. Kullmann et al.   NEUROSCIENCE

Control of the actin cytoskeleton in root hair development

(2012) Weike Pei et al.   PLANT SCIENCE

Preserved Morphology and Physiology of Excitatory Synapses in Profilin1-Deficient Mice

(2012) Andreas Görlich et al.   PLoS One

Role of the actin-binding protein profilin1 in radial migration and glial cell adhesion of granule neurons in the cerebellum

(2012) Marco B. Rust et al.   Cell Adhesion & Migration

Molecular insights on context-specific role of profilin-1 in cell migration

(2012) Zhijie Ding et al.   Cell Adhesion & Migration

The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin

(2011) Anna Nölle et al.   HUMAN MOLECULAR GENETICS

Piccolo Regulates the Dynamic Assembly of Presynaptic F-Actin

(2011) C. L. Waites et al.   JOURNAL OF NEUROSCIENCE

Profilin 1 is a Potential Biomarker for Bladder Cancer Aggressiveness

(2011) Jerome Zoidakis et al.   MOLECULAR & CELLULAR PROTEOMICS

Vascular hypertrophy-associated hypertension of profilin1 transgenic mouse model leads to functional remodeling of peripheral arteries

(2010) Mohamed D. H. Hassona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Refined solution structure of human profilin I

(2010) William J. Metzler et al.   PROTEIN SCIENCE

How depolymerization can promote polymerization: the case of actin and profilin

(2009) Elena G. Yarmola et al.   BIOESSAYS

Profilin 1 is required for abscission during late cytokinesis of chondrocytes

(2009) Ralph T Böttcher et al.   EMBO JOURNAL

Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins

(2009) Yong Ho Bae et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Profilin, a multi-modal regulator of neuronal plasticity

(2008) Andreas Birbach   BIOESSAYS