ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS

(2019) Desiree M Baron et al.   HUMAN MOLECULAR GENETICS

Feeling the force: formin’s role in mechanotransduction

(2019) Dennis Zimmermann et al.   CURRENT OPINION IN CELL BIOLOGY

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

(2019) Katja Burk et al.   ACTA NEUROPATHOLOGICA

Motor Neuron Susceptibility in ALS/FTD

(2019) Audrey M. G. Ragagnin et al.   Frontiers in Neuroscience

Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction

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Cellular quality control by the ubiquitin-proteasome system and autophagy

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Profilin and formin constitute a pacemaker system for robust actin filament growth

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Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

(2018) Edoardo Del Poggetto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of formin processivity by profilin and mechanical tension

(2018) Luyan Cao et al.   eLife

Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis

(2018) Mina Nekouei et al.   METABOLIC BRAIN DISEASE

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Profilin1 biology and its mutation, actin(g) in disease

(2016) Duah Alkam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity

(2016) Chunxing Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin and Actin-Binding Proteins

(2016) Thomas D. Pollard   Cold Spring Harbor Perspectives in Biology

Mutations of Profilin-1 Associated with Amyotrophic Lateral Sclerosis Promote Aggregation Due to Structural Changes of Its Native State

(2015) Edoardo Del Poggetto et al.   ACS Chemical Biology

Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways

(2015) Jeremy D. Rotty et al.   DEVELOPMENTAL CELL

Profilin Regulates F-Actin Network Homeostasis by Favoring Formin over Arp2/3 Complex

(2015) Cristian Suarez et al.   DEVELOPMENTAL CELL

Dynamic Coupling and Allosteric Networks in the α Subunit of Heterotrimeric G Proteins

(2015) Xin-Qiu Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel mutations support a role for Profilin 1 in the pathogenesis of ALS

(2015) Bradley N. Smith et al.   NEUROBIOLOGY OF AGING

Structural basis for mutation-induced destabilization of profilin 1 in ALS

(2015) Sivakumar Boopathy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics

(2014) M. D. Figley et al.   JOURNAL OF NEUROSCIENCE

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Small-Molecule Intramimics of Formin Autoinhibition: A New Strategy to Target the Cytoskeletal Remodeling Machinery in Cancer Cells

(2013) L. L. Lash et al.   CANCER RESEARCH

PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis

(2013) YongPing Chen et al.   NEUROBIOLOGY OF AGING

Formin mDia1 senses and generates mechanical forces on actin filaments

(2013) Antoine Jégou et al.   Nature Communications

Determinants of Formin Homology 1 (FH1) Domain Function in Actin Filament Elongation by Formins

(2012) Naomi Courtemanche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin stress fibers - assembly, dynamics and biological roles

(2012) S. Tojkander et al.   JOURNAL OF CELL SCIENCE

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts

(2012) Caroline Ingre et al.   NEUROBIOLOGY OF AGING

Individual Actin Filaments in a Microfluidic Flow Reveal the Mechanism of ATP Hydrolysis and Give Insight Into the Properties of Profilin

(2011) Antoine Jégou et al.   PLOS BIOLOGY

Fluorescence Lifetime Measurements and Biological Imaging

(2010) Mikhail Y. Berezin et al.   CHEMICAL REVIEWS

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

Formin Differentially Utilizes Profilin Isoforms to Rapidly Assemble Actin Filaments

(2008) Erin M. Neidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of the FH1 Domain and Profilin in Formin-Mediated Actin-Filament Elongation and Nucleation

(2007) Aditya Paul et al.   CURRENT BIOLOGY