Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression

Cancer-associated fibroblasts: overview, progress, challenges, and directions

(2021) Qinrong Ping et al.   CANCER GENE THERAPY

Macrophages and Extracellular Matrix in Breast Cancer: Partners in Crime or Protective Allies?

(2021) Claire Deligne et al.   Frontiers in Oncology

Key Matrix Remodeling Enzymes: Functions and Targeting in Cancer

(2021) Zoi Piperigkou et al.   Cancers

Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors

(2021) Emre Balta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma

(2021) Xinran O. Zhao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates

(2021) Robert S. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of the tumor microenvironment: are CAFs the Organizer?

(2021) Marina Kochetkova et al.   TRENDS IN CELL BIOLOGY

Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns

(2020) Stephen J. Galli et al.   Annual Review of Immunology

Neutrophils Modulate Fibroblast Function and Promote Healing and Scar Formation after Murine Myocardial Infarction †

(2020) Adelina Curaj et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism

(2020) Sarah Theresa Boyle et al.   NATURE CELL BIOLOGY

Enhanced Effect of Hyaluronan and Elastin Synthesis in Fibroblasts Through Lipopolysaccharide-activated Macrophages

(2020) TERUKO HONDA et al.   ANTICANCER RESEARCH

CD4+ T Cell Interstitial Migration Controlled by Fibronectin in the Inflamed Skin

(2020) Ninoshka R. J. Fernandes et al.   Frontiers in Immunology

Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment

(2020) Kaiyue Wu et al.   Frontiers in Immunology

Uncovering Tumor–Stroma Inter-relationships Using MALDI Mass Spectrometry Imaging

(2020) Sarah T. Boyle et al.   JOURNAL OF PROTEOME RESEARCH

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

(2020) David H. Peng et al.   Nature Communications

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

(2019) Kristopher R. Genschmer et al.   CELL

Mouse Mast Cell Protease-4 Recruits Leukocytes in the Inflammatory Phase of Surgically Wounded Skin

(2019) Julien Succar et al.   Advances in Wound Care

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Fibroblasts stimulate macrophage migration in interconnected extracellular matrices through tunnel formation and fiber alignment

(2019) Andrew J. Ford et al.   BIOMATERIALS

Role of Mast Cells in Shaping the Tumor Microenvironment

(2019) Daniel Elieh Ali Komi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Beyond proteases: Basement membrane mechanics and cancer invasion

(2019) Julie Chang et al.   JOURNAL OF CELL BIOLOGY

Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage

(2019) Amar Bennasroune et al.   MATRIX BIOLOGY

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling

(2019) Xinyi Wang et al.   Advances in Wound Care

The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets

(2019) Julie K. Nguyen et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix

(2019) Wenlong Zhang et al.   BRITISH JOURNAL OF CANCER

Topical Application Of A Mast Cell Stabilizer Improves Impaired Diabetic Wound Healing

(2019) Ana Tellechea et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mast cells are critical for controlling the bacterial burden and the healing of infected wounds

(2019) C. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysyl oxidases: linking structures and immunity in the tumor microenvironment

(2019) Paolo Tenti et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

(2019) Claire Vennin et al.   Nature Communications

Neutrophils suppress tumor‐infiltrating T cells in colon cancer via matrix metalloproteinase‐mediated activation of TGF β

(2019) Markus Germann et al.   EMBO Molecular Medicine

Collagen VI in healthy and diseased nervous system

(2018) Ilaria Gregorio et al.   Disease Models & Mechanisms

Periostin: A Matricellular Protein With Multiple Functions in Cancer Development and Progression

(2018) Laura González-González et al.   Frontiers in Oncology

Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models

(2018) Neri Amara et al.   ACS Chemical Biology

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis

(2018) Jacob Insua‐Rodríguez et al.   EMBO Molecular Medicine

Rho–ROCK signaling regulates tumor-microenvironment interactions

(2018) Mohammad Zahied Johan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mast cells as protectors of health

(2018) Anne Dudeck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7

(2018) Binbin Yu et al.   Cell Death & Disease

The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity

(2018) Valentina Poltavets et al.   Frontiers in Oncology

Membrane-bound stem cell factor is the major but not only driver of fibroblast-induced murine skin mast cell differentiation

(2017) Mandy Leist et al.   EXPERIMENTAL DERMATOLOGY

Endothelial cell-derived endothelin-1 is involved in abnormal scar formation by dermal fibroblasts through RhoA/Rho-kinase pathway

(2017) Koichiro Kiya et al.   EXPERIMENTAL DERMATOLOGY

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing

(2017) Mark Hesketh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6

(2016) Tim Vangansewinkel et al.   FASEB JOURNAL

Tumor macrophages are pivotal constructors of tumor collagenous matrix

(2016) Ran Afik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

(2016) Audrey Nosbaum et al.   JOURNAL OF IMMUNOLOGY

CD301b+ Macrophages Are Essential for Effective Skin Wound Healing

(2016) Brett Shook et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inhibition of IL-13-induced periostin in airway epithelium attenuates cellular protein expression of MUC5AC

(2016) Isao Suzaki et al.   RESPIROLOGY

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics

(2016) Steven O’Reilly et al.   Scientific Reports

The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential

(2016) Amandine Scandolera et al.   Frontiers in Pharmacology

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

(2015) Jasreen Kular et al.   DEVELOPMENTAL CELL

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

Role of the Tumor Microenvironment in Breast Cancer

(2015) Savas D. Soysal et al.   PATHOBIOLOGY

Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression

(2015) A Nukuda et al.   Oncogenesis

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

(2014) Kara L. Spiller et al.   BIOMATERIALS

Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study

(2014) Ying Chen et al.   Diagnostic Pathology

Absence of CD4 or CD8 lymphocytes changes infiltration of inflammatory cells and profiles of cytokine expression in skin wounds, but does not impair healing

(2014) Lin Chen et al.   EXPERIMENTAL DERMATOLOGY

Neutrophil extracellular traps promote differentiation and function of fibroblasts

(2014) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor- 1 in airway fibroblasts in asthma

(2013) R. Firszt et al.   EUROPEAN RESPIRATORY JOURNAL

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Damage-Associated Molecular Patterns Control Neutrophil Recruitment

(2013) Keir Pittman et al.   Journal of Innate Immunity

Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV

(2013) Michael G Overstreet et al.   NATURE IMMUNOLOGY

Neutrophils and Wound Repair: Positive Actions and Negative Reactions

(2013) Traci A. Wilgus et al.   Advances in Wound Care

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

(2012) Thomas Jamieson et al.   JOURNAL OF CLINICAL INVESTIGATION

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices

(2011) Alexandra Naba et al.   MOLECULAR & CELLULAR PROTEOMICS

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

(2011) R. O. Hynes et al.   Cold Spring Harbor Perspectives in Biology

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Jekyll and Hyde: the role of the microenvironment on the progression of cancer

(2010) Michael Allen et al.   JOURNAL OF PATHOLOGY

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Selective and Specific Macrophage Ablation Is Detrimental to Wound Healing in Mice

(2009) Rita Mirza et al.   AMERICAN JOURNAL OF PATHOLOGY

A Transgenic Mouse Model of Inducible Macrophage Depletion

(2009) Itamar Goren et al.   AMERICAN JOURNAL OF PATHOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Wound repair at a glance

(2009) T. J. Shaw et al.   JOURNAL OF CELL SCIENCE

Dynamics of Neutrophil Infiltration during Cutaneous Wound Healing and Infection Using Fluorescence Imaging

(2008) Min-Ho Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Progress in matrix metalloproteinase research

(2008) G MURPHY et al.   MOLECULAR ASPECTS OF MEDICINE

Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions

(2007) Brice Korkmaz et al.   BIOCHIMIE