Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

AMPK negatively regulates tensin-dependent integrin activity

(2017) Maria Georgiadou et al.   JOURNAL OF CELL BIOLOGY

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Fibronectin-guided migration of carcinoma collectives

(2017) Sandeep Gopal et al.   Nature Communications

Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence

(2017) Janusz Franco-Barraza et al.   eLife

Fibronectin: How Its Aberrant Expression in Tumors May Improve Therapeutic Targeting

(2017) Jennifer Peyling Wang et al.   Journal of Cancer

Tissue elasticity properties as biomarkers for prostate cancer

(2017) Kenneth Hoyt et al.   Cancer Biomarkers

The extracellular matrix in breast cancer

(2016) Jacob Insua-Rodríguez et al.   ADVANCED DRUG DELIVERY REVIEWS

Matrix control of pancreatic cancer: New insights into fibronectin signaling

(2016) Mary Topalovski et al.   CANCER LETTERS

Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600Eand Pten Loss

(2016) Lee Ann Jolly et al.   CANCER RESEARCH

The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas

(2016) Yoshihiro Mezawa et al.   CELL AND TISSUE RESEARCH

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis

(2016) Cassie J. Clarke et al.   CURRENT BIOLOGY

SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland

(2016) Emilia Peuhu et al.   EMBO JOURNAL

Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI)

(2016) I García-Palmero et al.   ONCOGENE

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

(2016) Riina Kaukonen et al.   Nature Communications

IL-17 and insulin/IGF1 enhance adhesion of prostate cancer cells to vascular endothelial cells through CD44-VCAM-1 interaction

(2015) Chong Chen et al.   PROSTATE

Stretching Fibroblasts Remodels Fibronectin and Alters Cancer Cell Migration

(2015) Mingfang Ao et al.   Scientific Reports

PDGFRα plays a crucial role in connective tissue remodeling

(2015) Shinjiro Horikawa et al.   Scientific Reports

Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis

(2014) J. Stanisavljevic et al.   CANCER RESEARCH

Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage–stellate cell interaction

(2014) Chanjuan Shi et al.   LABORATORY INVESTIGATION

Insidious Changes in Stromal Matrix Fuel Cancer Progression

(2014) Fayth L. Miles et al.   MOLECULAR CANCER RESEARCH

The Rho family GEF Asef2 regulates cell migration in three dimensional (3D) collagen matrices through myosin II

(2014) Léolène Jean et al.   Cell Adhesion & Migration

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Targeting the PDGF signaling pathway in tumor treatment

(2013) Carl-Henrik Heldin   Cell Communication and Signaling

Integrins in mechanotransduction

(2013) Tyler D Ross et al.   CURRENT OPINION IN CELL BIOLOGY

Activation of beta 1 but not beta 3 integrin increases cell traction forces

(2013) Grace L. Lin et al.   FEBS LETTERS

Platelet-derived growth factor signaling in mesenchymal cells

(2013) Johanna Donovan   Frontiers in Bioscience-Landmark

Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer

(2013) Young Kyung Bae et al.   HUMAN PATHOLOGY

Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen

(2013) Léolène Jean et al.   JOURNAL OF CELL SCIENCE

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Characterizing Stiffness of Human Prostates Using Acoustic Radiation Force

(2013) Liang Zhai et al.   ULTRASONIC IMAGING

Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation

(2012) S. R. Barthel et al.   CANCER RESEARCH

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis

(2012) Mark Sutherland et al.   Cancers

Syndecan-1 in Breast Cancer Stroma Fibroblasts Regulates Extracellular Matrix Fiber Organization and Carcinoma Cell Motility

(2011) Ning Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

(2011) Hyung-Ok Lee et al.   BMC CANCER

Mesenchymal stem cell migration is regulated by fibronectin through  5 1-integrin-mediated activation of PDGFR-  and potentiation of growth factor signals

(2011) J. Veevers-Lowe et al.   JOURNAL OF CELL SCIENCE

Golgi Bypass: Skirting Around the Heart of Classical Secretion

(2011) A. G. Grieve et al.   Cold Spring Harbor Perspectives in Biology

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Cell Traction Forces Direct Fibronectin Matrix Assembly

(2009) Christopher A. Lemmon et al.   BIOPHYSICAL JOURNAL

Regulation of Platelet-derived Growth Factor Receptor Function by Integrin-associated Cell Surface Transglutaminase

(2009) Evgeny A. Zemskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incorporation of Tenascin-C into the Extracellular Matrix by Periostin Underlies an Extracellular Meshwork Architecture

(2009) Isao Kii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

(2008) Karl E Kadler et al.   CURRENT OPINION IN CELL BIOLOGY

Cell adhesion receptors in mechanotransduction

(2008) Martin A Schwartz et al.   CURRENT OPINION IN CELL BIOLOGY

Integrins in prostate cancer progression

(2008) H. L. Goel et al.   ENDOCRINE-RELATED CANCER

High Resolution Traction Force Microscopy Based on Experimental and Computational Advances

(2007) Benedikt Sabass et al.   BIOPHYSICAL JOURNAL