Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease

Oxidative Stress, Neuroinflammation, and NADPH Oxidase: Implications in the Pathogenesis and Treatment of Alzheimer’s Disease

(2021) Upasana Ganguly et al.   Oxidative Medicine and Cellular Longevity

Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo

(2021) Taro Saito et al.   HUMAN MOLECULAR GENETICS

Redox-Active Metal Ions and Amyloid-Degrading Enzymes in Alzheimer’s Disease

(2021) Namdoo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer’s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies

(2021) Tao Song et al.   AGEING RESEARCH REVIEWS

Recent Advances in Molecular Pathways and Therapeutic Implications Targeting Mitochondrial Dysfunction for Alzheimer’s Disease

(2021) Rishika Dhapola et al.   MOLECULAR NEUROBIOLOGY

Nrf2: a dark horse in Alzheimer's disease treatment

(2020) Alsiddig Osama et al.   AGEING RESEARCH REVIEWS

Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer's Neuropathology

(2020) Anna Fracassi et al.   JOURNAL OF NEUROSCIENCE

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

(2020) Alberto Serrano-Pozo et al.   LANCET NEUROLOGY

Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

(2020) Brian V. Lananna et al.   Science Translational Medicine

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease

(2020) Anamitra Ghosh et al.   Science Translational Medicine

Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease

(2019) Tomris Ozben et al.   CLINICAL BIOCHEMISTRY

Metal Ions in Alzheimer’s Disease: A Key Role or Not?

(2019) Yan Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

(2019) Yoko Yagishita et al.   MOLECULES

Oxidative Damage of DNA as Early Marker of Alzheimer’s Disease

(2019) Carmen Peña-Bautista et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Link of impaired metal ion homeostasis to mitochondrial dysfunction in neurons

(2018) Eunju Nam et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements

(2018) Jit Poddar et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms

(2018) Angela Trovato Salinaro et al.   Immunity & Ageing

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Role of copper transporters in copper homeostasis

(2018) Joseph R Prohaska   AMERICAN JOURNAL OF CLINICAL NUTRITION

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

(2018) Masha G. Savelieff et al.   CHEMICAL REVIEWS

In vivo molecular imaging of neuroinflammation in Alzheimer's disease

(2018) Aisling Chaney et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Zinc Signal in Brain Diseases

(2017) Stuart Portbury et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

(2017) Clémence Cheignon et al.   Chemical Science

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

(2017) Gargi Ganguly et al.   Drug Design Development and Therapy

Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts

(2017) Alejandro Ibáñez-Salazar et al.   Frontiers in Neuroscience

Amyloid-β Peptide Fibrils Induce Nitro-Oxidative Stress in Neuronal Cells

(2017) Gerard Ill-Raga et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients

(2016) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons

(2016) Chang Hun Cho et al.   FREE RADICAL RESEARCH

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

(2016) Manuela Pennisi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study

(2016) Stephen B. Wharton et al.   Acta Neuropathologica Communications

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

(2016) Robert A. Wise et al.   PLoS One

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions

(2015) Y. Kizuka et al.   BIOCHEMICAL JOURNAL

Oxidative Stress in Alzheimer’s Disease: Should We Keep Trying Antioxidant Therapies?

(2015) Michelli Erica Souza Ferreira et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

(2015) Zhenzhen Liu et al.   Oxidative Medicine and Cellular Longevity

Copper in Alzheimer’s disease: Implications in amyloid aggregation and neurotoxicity

(2015) Patrick Gamez et al.   AIP Advances

Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases

(2015) Sandro Dattilo et al.   Immunity & Ageing

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

(2014) D. Allan Butterfield et al.   BIOCHEMICAL JOURNAL

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

(2014) Li Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?

(2014) Torbjörn Persson et al.   Oxidative Medicine and Cellular Longevity

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation

(2014) Yunpeng Huang et al.   Cell Reports

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

(2013) Henry J. Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H2O2

(2013) Ye Feng et al.   JOURNAL OF NEUROCHEMISTRY

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product?

(2013) Greg T Sutherland et al.   REDOX REPORT

Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a “chi”

(2013) Carolin Cornelius et al.   Immunity & Ageing

Diphenyleneiodonium, an inhibitor of NOXes and DUOXes, is also an iodide-specific transporter

(2013) C. Massart et al.   FEBS Open Bio

NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS

(2012) Eugenia Cifuentes-Pagano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antioxidant Therapies for Alzheimer's Disease

(2012) Ye Feng et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

(2011) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Amyloid-β Production: Major Link Between Oxidative Stress and BACE1

(2011) Elena Tamagno et al.   NEUROTOXICITY RESEARCH

Mutations in FLVCR1 Cause Posterior Column Ataxia and Retinitis Pigmentosa

(2010) Anjali M. Rajadhyaksha et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

(2010) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

(2010) Li Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of α-, β- and γ-secretase expression

(2009) Ricardo Quiroz-Baez et al.   NEUROCHEMISTRY INTERNATIONAL

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

(2009) Bo Su et al.   NEUROSCIENCE LETTERS

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

(2009) Marzia Perluigi et al.   Proteomics Clinical Applications

Catalase and glutathione peroxidase mimics

(2008) Brian J. Day   BIOCHEMICAL PHARMACOLOGY

Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific

(2008) Elisabetta Aldieri et al.   CURRENT DRUG METABOLISM

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY