Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

Activation of mitochondrial energy metabolism protects against cardiac failure

(2016) Tim J. Schulz et al.   Aging-US

Editorial [Hot Topic: Oxidative Stress Induced-Metabolic Imbalance, Mitochondrial Failure, And Cellular Hypoperfusion As Primary Pathogenetic Factors For The Development Of Alzheimer Disease Which Can Be Used As An Alternate And Successful Drug Treatment Strategy: Past, Present And Future (Guest Editor: Gjumrakch Aliev)]

(2012) Gjumrakch Aliev   CNS & Neurological Disorders-Drug Targets

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

Sources of variability in estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Robert S. Wilson et al.   Alzheimers & Dementia

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells

(2011) David J. Rowlands et al.   HYPERTENSION

Cell signaling and receptors with resorcinols and flavonoids: redox, reactive oxygen species, and physiological effects

(2011) Peter Kovacic et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Matrix Metalloproteinases Are Associated With Increased Blood–Brain Barrier Opening in Vascular Cognitive Impairment

(2011) Eduardo Candelario-Jalil et al.   STROKE

Dietary Inflammation Factor Rating System and Risk of Alzheimer Disease in Elders

(2010) Yian Gu et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Evidence for the Involvement of Apoptosis-Inducing Factor–Mediated Caspase-Independent Neuronal Death in Alzheimer Disease

(2010) Wenfeng Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation and Alzheimer’s disease

(2010) Young-Jung Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE)

(2010) Rui Kang et al.   Autophagy

Degradation of Soluble and Fibrillar Amyloid β-Protein by Matrix Metalloproteinase (MT1-MMP)in Vitro

(2010) Mei-Chen Liao et al.   BIOCHEMISTRY

Biomarkers of oxidative damage and inflammation in Alzheimer’s disease

(2010) Douglas Galasko et al.   Biomarkers in Medicine

PPARγ inhibits inflammatory reaction in oxidative stress induced human diploid fibloblast

(2010) Young-Hee Lee et al.   CELL BIOCHEMISTRY AND FUNCTION

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease

(2010) P. Alexiou et al.   CURRENT MEDICINAL CHEMISTRY

Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer’s disease

(2010) Pancham Bakshi et al.   CYTOKINE

Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier

(2010) Corbin Bachmeier et al.   CYTOTECHNOLOGY

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

(2010) Joshua B. Owen et al.   FREE RADICAL BIOLOGY AND MEDICINE

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

(2010) Li Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective strategies involving ROS in Alzheimer disease

(2010) Magali Dumont et al.   FREE RADICAL BIOLOGY AND MEDICINE

Progress and prospects: stem cells and neurological diseases

(2010) S Gögel et al.   GENE THERAPY

Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease

(2010) Solveig Horstmann et al.   INTERNATIONAL PSYCHOGERIATRICS

Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

(2010) Jian Guo Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress Increases Blood–Brain Barrier Permeability and Induces Alterations in Occludin during Hypoxia–Reoxygenation

(2010) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Increase in blood-brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury

(2010) Ryan D. Readnower et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Oxidative stress in Alzheimer's disease hippocampus: A topographical study

(2010) F.F. Cruz-Sánchez et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3)

(2010) Kalimuthu Senthilkumar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics

(2010) Christopher D. Aluise et al.   NEUROBIOLOGY OF DISEASE

Age-related loss of phospholipid asymmetry in APPNLh/APPNLh x PS-1P264L/PS-1P264L human double mutant knock-in mice: Relevance to Alzheimer disease

(2010) Miranda L. Bader Lange et al.   NEUROBIOLOGY OF DISEASE

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

The interleukin-6 gene −572C/G promoter polymorphism modifies Alzheimer's risk in APOE ɛ4 carriers

(2010) Min Wang et al.   NEUROSCIENCE LETTERS

β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

(2010) Erica Buoso et al.   PHARMACOLOGICAL RESEARCH

Vascular pathology in Alzheimer's disease

(2010) Taihei MIYAKAWA   Psychogeriatrics

Inflammation, Cytokines, Immune Response, Apolipoprotein E, Cholesterol, and Oxidative Stress in Alzheimer Disease: Therapeutic Implications

(2010) Giuseppina Candore et al.   REJUVENATION RESEARCH

Neuronal protein trafficking associated with Alzheimer disease

(2010) Bor Luen Tang   Cell Adhesion & Migration

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Polymorphisms of the IL-1 Gene Complex Are Associated With Alcohol Dependence in Spanish Caucasians: Data From an Association Study

(2009) Pilar A. Saiz et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The Role of Neuroimmunomodulation in Alzheimer's Disease

(2009) Ricardo B. Maccioni et al.   Annals of the New York Academy of Sciences

Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency

(2009) G. Tibolla et al.   ATHEROSCLEROSIS

Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy

(2009) Alex Y. Strongin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduction of Cerebral Oxidative Stress Following Environmental Enrichment in Mice with Alzheimer-Like Pathology

(2009) Arne Herring et al.   BRAIN PATHOLOGY

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier hyperpermeability

(2009) C. L. Allen et al.   DIABETES OBESITY & METABOLISM

Biomarkers of inflammation and amyloid-β phagocytosis in patients at risk of Alzheimer disease

(2009) Milan Fiala et al.   EXPERIMENTAL GERONTOLOGY

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Inhibition of γ-secretase activity reduces Aβ production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease

(2009) Baiyang Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

(2009) C. L. Allen et al.   International Journal of Stroke

Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment

(2009) Rukhsana Sultana et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Methamphetamine Disrupts Blood–Brain Barrier Function by Induction of Oxidative Stress in Brain Endothelial Cells

(2009) Servio H Ramirez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

(2009) Onofre Combarros et al.   Journal of Neuroinflammation

Blood-brain barrier alterations in ageing and dementia

(2009) Bogdan O. Popescu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Apoptotic mechanisms involved in neurodegenerative diseases: Experimental and therapeutic approaches

(2009) A. Camins et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Why lipids are important for Alzheimer disease?

(2009) Veronica Hirsch-Reinshagen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

Activated astroglia during chronic inflammation in Alzheimer's disease—Do they neglect their neurosupportive roles?

(2009) Stacey Fuller et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

(2009) J. E. Simpson et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Downregulation of LPR1 at the blood–brain barrier in streptozotocin-induced diabetic mice

(2009) Hao Hong et al.   NEUROPHARMACOLOGY

Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice

(2009) X. Zhang et al.   NEUROSCIENCE

Matrix metalloproteinases-2 and -3 are reduced in cerebrospinal fluid with low beta-amyloid1–42 levels

(2009) Reinhilde Mlekusch et al.   NEUROSCIENCE LETTERS

Mechanisms Involved in the Modulation of Astroglial Resistance to Oxidative Stress Induced by Activated Microglia: Antioxidative Systems, Peroxide Elimination, Radical Generation, Lipid Peroxidation

(2009) Claudia Röhl et al.   NEUROTOXICITY RESEARCH

Specific Human Astrocyte Subtype Revealed by Affinity Purified GFAP+1 Antibody; Unpurified Serum Cross-Reacts with Neurofilament-L in Alzheimer

(2009) Jinte Middeldorp et al.   PLoS One

Transport of Alzheimer Disease Amyloid-β-Binding d-Amino Acid Peptides across an In Vitro Blood–Brain Barrier Model

(2009) Hongmei Liu et al.   REJUVENATION RESEARCH

Upregulation of RAGE at the blood-brain barrier in streptozotocin-induced diabetic mice

(2009) Li Ping Liu et al.   SYNAPSE

Novel Role of CXCR2 in Regulation of γ-Secretase Activity

(2008) Pancham Bakshi et al.   ACS Chemical Biology

Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia

(2008) Fu-Ling Yan et al.   ACTA NEUROPATHOLOGICA

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

(2008) Jack T. Rogers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interrelation of inflammation and APP in sIBM: IL-1β induces accumulation of β-amyloid in skeletal muscle

(2008) Jens Schmidt et al.   BRAIN

Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

(2008) Anna Sokolova et al.   BRAIN PATHOLOGY

Beta-Secretase: Structure, Function, and Evolution

(2008) Chitra Venugopal et al.   CNS & Neurological Disorders-Drug Targets

Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease

(2008) George Perry et al.   CNS & Neurological Disorders-Drug Targets

Amyloid-Degrading Enzymes as Therapeutic Targets in Alzheimers Disease

(2008) Natalia Nalivaeva et al.   Current Alzheimer Research

Evidence for Altered LRP/RAGE Expression in Alzheimer Lesion Pathogenesis

(2008) Brian Jeynes et al.   Current Alzheimer Research

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

The role of metals in modulating metalloprotease activity in the AD brain

(2008) Gulay Filiz et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease

(2008) Giovanna Cenini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

(2008) Yifeng Du et al.   FREE RADICAL BIOLOGY AND MEDICINE

Convergence of nitric oxide and lipid signaling: Anti-inflammatory nitro-fatty acids

(2008) Paul R.S. Baker et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased expression of the γ-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury

(2008) Yasmine Nadler et al.   GLIA

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology

(2008) Sarah L. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases

(2008) Ling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

(2008) Giovanna Cenini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Brain Redox Imaging Using Blood—Brain Barrier-Permeable Nitroxide MRI Contrast Agent

(2008) Fuminori Hyodo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid peroxidation up-regulates BACE1 expressionin vivo: a possible early event of amyloidogenesis in Alzheimer’s disease

(2008) Liuji Chen et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress

(2008) Kang-Woo Lee et al.   JOURNAL OF NEUROCHEMISTRY

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

(2008) Solomon S Shaftel et al.   Journal of Neuroinflammation

Apolipoprotein E, Amyloid-β, and Blood-Brain Barrier Permeability in Alzheimer Disease

(2008) John E. Donahue et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Therapeutic Strategies for Alzheimer’s Disease

(2008) Donna M. Barten et al.   MOLECULAR NEUROBIOLOGY

Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment

(2008) Peder Buchhave et al.   NEUROBIOLOGY OF AGING

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE

Metalloproteinase’s Activity and Oxidative Stress in Mild Cognitive Impairment and Alzheimer’s Disease

(2008) Sagrario Martín-Aragón et al.   NEUROCHEMICAL RESEARCH

Survival in Alzheimer disease: A multiethnic, population-based study of incident cases

(2008) E. P. Helzner et al.   NEUROLOGY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

(2008) M. Matos et al.   NEUROSCIENCE

Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: Consequences for proteomic analyses

(2008) Mohamed Zouambia et al.   PROTEOMICS

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Alterations of some membrane transport proteins in Alzheimer's disease: role of amyloid β-peptide

(2007) Rukhsana Sultana et al.   Molecular BioSystems

Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease

(2007) Miranda L. Bader Lange et al.   NEUROBIOLOGY OF DISEASE