Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

Oxidation Reactions with Bioinspired Mononuclear Non-Heme Metal-Oxo Complexes

(2016) Xenia Engelmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

(2016) Danuta S. Kalinowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

(2016) Clémence Cheignon et al.   DALTON TRANSACTIONS

Spectroscopic and Theoretical Study of CuI Binding to His111 in the Human Prion Protein Fragment 106–115

(2016) Trinidad Arcos-López et al.   INORGANIC CHEMISTRY

Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein

(2016) Esaú E. Rodríguez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Coordination and redox properties of copper interaction with α-synuclein

(2016) Daniela Valensin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Role of iron in neurodegenerative diseases

(2016) Kai Li et al.   JOURNAL OF NEURAL TRANSMISSION

Structure of the Reduced Copper Active Site in Preprocessed Galactose Oxidase: Ligand Tuning for One-Electron O2 Activation in Cofactor Biogenesis

(2016) Ryan E. Cowley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing

(2016) Jeppe T. Pedersen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

(2016) Clémence Cheignon et al.   Metallomics

Free Superoxide is an Intermediate in the Production of H2 O2 by Copper(I)-Aβ Peptide and O2

(2015) Karine Reybier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On the generation of OH· radical species from H2O2 by Cu(I) amyloid beta peptide model complexes: a DFT investigation

(2015) Tommaso Prosdocimi et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Copper(i) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

(2015) E. Atrián-Blasco et al.   Metallomics

Dioxygen activation in the Cu–amyloid β complex

(2015) Andrea Mirats et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Metal Ions and Intrinsically Disordered Proteins and Peptides: From Cu/Zn Amyloid-β to General Principles

(2014) Peter Faller et al.   ACCOUNTS OF CHEMICAL RESEARCH

Copper Active Sites in Biology

(2014) Edward I. Solomon et al.   CHEMICAL REVIEWS

Redox Cycling of Copper–Amyloid β 1–16 Peptide Complexes Is Highly Dependent on the Coordination Mode

(2014) Lidia G. Trujano-Ortiz et al.   INORGANIC CHEMISTRY

Site-Specific Copper-Catalyzed Oxidation of α-Synuclein: Tightening the Link between Metal Binding and Protein Oxidative Damage in Parkinson’s Disease

(2014) Marco C. Miotto et al.   INORGANIC CHEMISTRY

β-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species

(2014) Jennifer Mayes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capturing a Reactive State of Amyloid Aggregates

(2014) Sudhakar Parthasarathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Oxygen-Based Ligand of the Low pH Component of the Cu2+-Amyloid-β Complex

(2014) Carlos Z. Gomez-Castro et al.   JOURNAL OF PHYSICAL CHEMISTRY B

An integrated study of the affinities of the Aβ16 peptide for Cu(i) and Cu(ii): implications for the catalytic production of reactive oxygen species

(2014) Tessa R. Young et al.   Metallomics

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

Copper–amyloid-β complex may catalyze peroxynitrite production in brain: evidence from molecular modeling

(2014) Roberto Giacovazzi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production

(2013) Laure-Estelle Cassagnes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

(2013) Bruno Alies et al.   CHEMICAL COMMUNICATIONS

Copper and Heme-Mediated Abeta Toxicity: Redox Chemistry, Abeta Oxidations and Anti-ROS Compounds

(2013) Stefan Chassaing et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Identifying, By First-Principles Simulations, Cu[Amyloid-β] Species Making Fenton-Type Reactions in Alzheimer’s Disease

(2013) Giovanni La Penna et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Stepwise Protonation and Electron-Transfer Reduction of a Primary Copper–Dioxygen Adduct

(2013) Ryan L. Peterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu(II) Affinity for the Alzheimer’s Peptide: Tyrosine Fluorescence Studies Revisited

(2012) Bruno Alies et al.   ANALYTICAL CHEMISTRY

Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease

(2012) Gözde Eskici et al.   BIOCHEMISTRY

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

(2012) Christelle Hureau   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 2: Dependence of Cu(II) binding sites with Aβ sequences

(2012) Christelle Hureau et al.   COORDINATION CHEMISTRY REVIEWS

Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

(2012) Henryk Kozlowski et al.   COORDINATION CHEMISTRY REVIEWS

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Copper Coordination to Native N-Terminally Modified versus Full-Length Amyloid-β: Second-Sphere Effects Determine the Species Present at Physiological pH

(2012) Bruno Alies et al.   INORGANIC CHEMISTRY

A new water-soluble Cu(II) chelator that retrieves Cu from Cu(amyloid-β) species, stops associated ROS production and prevents Cu(II)‐induced Aβ aggregation

(2012) Sabrina Noël et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Modeling Copper Binding to the Amyloid-β Peptide at Different pH: Toward a Molecular Mechanism for Cu Reduction

(2012) Sara Furlan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Heterogeneous Nature of Cu2+Interactions with Alzheimer’s Amyloid-β Peptide

(2011) Simon C. Drew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Reevaluation of Copper(I) Affinity for Amyloid-β Peptides by Competition with Ferrozine-An Unusual Copper(I) Indicator

(2011) Bruno Alies et al.   CHEMISTRY-A EUROPEAN JOURNAL

pH-Dependent Cu(II) Coordination to Amyloid-β Peptide: Impact of Sequence Alterations, Including the H6R and D7N Familial Mutations.

(2011) Bruno Alies et al.   INORGANIC CHEMISTRY

The role of metallobiology and amyloid-β peptides in Alzheimer’s disease

(2011) Blaine R. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

New Insights into the Coordination of Cu(II) by the Amyloid-B 16 Peptide from Fourier Transform IR Spectroscopy and Isotopic Labeling

(2011) Youssef El Khoury et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Copper(II) Coordination to Amyloid β: Murine versus Human Peptide

(2010) Hélène Eury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaction Rates and Mechanism of the Ascorbic Acid Oxidation by Molecular Oxygen Facilitated by Cu(II)-Containing Amyloid-β Complexes and Aggregates

(2010) Dianlu Jiang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-  copper complex follow a preorganization mechanism

(2010) V. Balland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening Assay for Metal-Catalyzed Oxidation Inhibitors Using Liquid Chromatography−Mass Spectrometry with an N-Terminal β-Amyloid Peptide

(2009) Koichi Inoue et al.   ANALYTICAL CHEMISTRY

Deprotonation of the Asp1Ala2 Peptide Bond Induces Modification of the Dynamic Copper(II) Environment in the Amyloid-β Peptide near Physiological pH

(2009) Christelle Hureau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pulse EPR Spectroscopy Reveals the Coordination Sphere of Copper(II) Ions in the 1–16 Amyloid-β Peptide: A Key Role of the First Two N-Terminus Residues

(2009) Pierre Dorlet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aβ-mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease

(2009) Christelle Hureau et al.   BIOCHIMIE

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-β complexes

(2009) Christelle Hureau et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Mechanism of Hydrogen Peroxide Production by Copper-Bound Amyloid Beta Peptide: A Theoretical Study

(2009) Nadine Hewitt et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Pleomorphic Copper Coordination by Alzheimer’s Disease Amyloid-β Peptide

(2009) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identifying the Minimal Copper- and Zinc-binding Site Sequence in Amyloid-β Peptides

(2008) Velia Minicozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amyloid-β Peptide of Alzheimer’s Disease Binds CuIin a Linear Bis-His Coordination Environment: Insight into a Possible Neuroprotective Mechanism for the Amyloid-β Peptide

(2008) Jason Shearer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biologically inspired oxidation catalysis

(2008) Lawrence Que et al.   NATURE