Inclusion of extracellular matrix molecules and necrostatin-1 in the intracapsular environment of alginate-based microcapsules synergistically protects pancreatic β cells against cytokine-induced inflammatory stress

The effects of necrostatin‐1 on the in vitro development and function of young porcine islets over 14‐day prolonged tissue culture

(2021) Hien Lau et al.   XENOTRANSPLANTATION

Acetate and Butyrate Improve β-cell Metabolism and Mitochondrial Respiration under Oxidative Stress

(2020) Shuxian Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ERK signalling: a master regulator of cell behaviour, life and fate

(2020) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interpenetrating Network of Alginate–Human Adipose Extracellular Matrix Hydrogel for Islet Cells Encapsulation

(2020) Jun Kit Wang et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival

(2020) Shuxian Hu et al.   BIOMATERIALS

Effect of alginate matrix engineered to mimic the pancreatic microenvironment on encapsulated islet function

(2020) Kevin Enck et al.   BIOTECHNOLOGY AND BIOENGINEERING

Low methyl-esterified pectin protects pancreatic β-cells against diabetes-induced oxidative and inflammatory stress via galectin-3

(2020) Shuxian Hu et al.   CARBOHYDRATE POLYMERS

Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications

(2020) Liyuan Cao et al.   PHARMACOLOGICAL RESEARCH

Dose-dependent effects of necrostatin-1 supplementation to tissue culture media of young porcine islets

(2020) Hien Lau et al.   PLoS One

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

(2019) Saurabh Vig et al.   Cell Death & Disease

Interconnected Toroidal Hydrogels for Islet Encapsulation

(2019) Alexander U. Ernst et al.   Advanced Healthcare Materials

Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

(2019) Wenjun Xiong et al.   Frontiers in Physiology

What is the role of peptide fragments of collagen I and IV in health and disease?

(2019) Andrew Kisling et al.   LIFE SCIENCES

Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation

(2019) Shuixan Hu et al.   Frontiers in Bioengineering and Biotechnology

RGD-containing elastin-like polypeptide improves islet transplantation outcomes in diabetic mice

(2019) Kyeong-Min Lee et al.   Acta Biomaterialia

Extracellular matrix-derived biomaterials in engineering cell function

(2019) Hao Xing et al.   BIOTECHNOLOGY ADVANCES

Necrostatin‐1 supplementation enhances young porcine islet maturation and in vitro function

(2019) Hien Lau et al.   XENOTRANSPLANTATION

Advances in β-cell replacement therapy for the treatment of type 1 diabetes

(2019) Marie-Christine Vantyghem et al.   LANCET

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

(2019) Qingsheng Liu et al.   Nature Communications

Therapeutic Strategies for Modulating the Extracellular Matrix to Improve Pancreatic Islet Function and Survival After Transplantation

(2018) Alexandra M. Smink et al.   Current Diabetes Reports

Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets

(2018) L. Alberto Llacua et al.   DIABETOLOGIA

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

Rebuilding a better home for transplanted islets

(2018) Daniel M. Tremmel et al.   Organogenesis

Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques

(2018) Matthew A. Bochenek et al.   Nature Biomedical Engineering

Laminin and collagen IV inclusion in immunoisolating microcapsules reduces cytokine-mediated cell death in human pancreatic islets

(2017) L. Alberto Llacua et al.   Journal of Tissue Engineering and Regenerative Medicine

RIP1-dependent reactive oxygen species production executes artesunate-induced cell death in renal carcinoma Caki cells

(2017) Anil Kumar Chauhan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival

(2017) Hirotake Komatsu et al.   PLoS One

Drp1 guarding of the mitochondrial network is important for glucose-stimulated insulin secretion in pancreatic beta cells

(2016) Florian Reinhardt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular matrix components supporting human islet function in alginate-based immunoprotective microcapsules for treatment of diabetes

(2016) Alberto Llacua et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

Enzymes for Pancreatic Islet Isolation Impact Chemokine-Production and Polarization of Insulin-Producing β-Cells with Reduced Functional Survival of Immunoisolated Rat Islet-Allografts as a Consequence

(2016) Paul de Vos et al.   PLoS One

Essential phospholipids prevent islet damage induced by proinflammatory cytokines and hypoxic conditions

(2015) Rauf Shahbazov et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?

(2015) Eliška Holzerová et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DAMP production by human islets under low oxygen and nutrients in the presence or absence of an immunoisolating-capsule and necrostatin-1

(2015) Genaro A. Paredes-Juarez et al.   Scientific Reports

Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells

(2014) Swapnil V. Bhujbal et al.   Journal of the Mechanical Behavior of Biomedical Materials

Necroptosis in health and diseases

(2014) Wen Zhou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necrostatin-1 inhibits Hmgb1-IL-23/IL-17 pathway and attenuates cardiac ischemia reperfusion injury

(2014) Anbin Zhang et al.   TRANSPLANT INTERNATIONAL

Inflammatory Response in Islet Transplantation

(2014) Mazhar A. Kanak et al.   International Journal of Endocrinology

A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells

(2014) Swapnil V. Bhujbal et al.   Scientific Reports

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

Redox-Relevant Aspects of the Extracellular Matrix and Its Cellular Contacts via Integrins

(2013) Johannes A. Eble et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival

(2013) Antonio Citro et al.   Current Diabetes Reports

Mitochondrial function and insulin secretion

(2013) Pierre Maechler   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Collagen IV-Modified Scaffolds Improve Islet Survival and Function and Reduce Time to Euglycemia

(2013) Woon Teck Yap et al.   TISSUE ENGINEERING PART A

Mitochondrial dynamics and morphology in beta-cells

(2012) Linsey Stiles et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial signal transduction in pancreatic β-cells

(2012) Pierre Maechler   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel

(2012) Nicolynn E. Davis et al.   BIOMATERIALS

Long-Term Metabolic and Immunological Follow-Up of Nonimmunosuppressed Patients With Type 1 Diabetes Treated With Microencapsulated Islet Allografts: Four cases

(2011) G. Basta et al.   DIABETES CARE

NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells

(2011) Yoshiaki Tamura et al.   FEBS LETTERS

Cytokines in the Progression of Pancreaticβ-Cell Dysfunction

(2010) Chunjiong Wang et al.   International Journal of Endocrinology

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES