Redox-Relevant Aspects of the Extracellular Matrix and Its Cellular Contacts via Integrins

Regulation of Platelet Activity in a Changing Redox Environment

(2013) Desmond D. Murphy et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases in Redox Regulation of Cell Adhesion and Migration

(2013) Katrin Schröder   ANTIOXIDANTS & REDOX SIGNALING

Redox Circuitries Driving Src Regulation

(2013) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles

(2013) Johanna Myllyharju et al.   BIOLOGICAL CHEMISTRY

The antagonistic roles of PDGF and integrin αvβ3 in regulating ROS production at focal adhesions

(2013) Li-Jung Lin et al.   BIOMATERIALS

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by InducingP4HA1, P4HA2,andPLOD2Expression in Fibroblasts

(2013) Daniele M. Gilkes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

The history of matrix metalloproteinases: milestones, myths, and misperceptions

(2012) Rugmani Padmanabhan Iyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cell migration and invasion in human disease: the Tks adaptor proteins

(2012) Sara A. Courtneidge   BIOCHEMICAL SOCIETY TRANSACTIONS

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

(2012) Kristin Moreth et al.   CELL CYCLE

Novel insights into leukocyte extravasation

(2012) Dietmar Vestweber   CURRENT OPINION IN HEMATOLOGY

The glomerular basement membrane

(2012) Jeffrey H. Miner   EXPERIMENTAL CELL RESEARCH

Glycosaminoglycans: key players in cancer cell biology and treatment

(2012) Nikos Afratis et al.   FEBS Journal

Integrin α7β1 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesion

(2012) Flávia Figueiredo de Rezende et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of N-acetylcysteine and GSH redox system on total and active MMP-2 in intestinal myofibroblasts of Crohn's disease patients

(2012) Cecilia Romagnoli et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Unique Disulfide Bonds in Epidermal Growth Factor (EGF) Domains of β3 Affect Structure and Function of αIIbβ3 and αvβ3 Integrins in Different Manner

(2012) Ronit Mor-Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

The myofibroblast matrix: implications for tissue repair and fibrosis

(2012) Franco Klingberg et al.   JOURNAL OF PATHOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Knockdown of hypoxia-inducible factor-1α accelerates peritoneal dissemination via the upregulation of MMP-1 expression in gastric cancer cell lines

(2012) MASATSUGU HIRAKI et al.   Experimental and Therapeutic Medicine

The role of the myofibroblast in tumor stroma remodeling

(2012) Marcela Otranto et al.   Cell Adhesion & Migration

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation

(2011) Carlos Mas-Moruno et al.   Anti-Cancer Agents in Medicinal Chemistry

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

(2011) Stephanie Carnesecchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hypoxia-inducible factor signaling in the development of tissue fibrosis

(2011) Debra F. Higgins et al.   CELL CYCLE

Redox signaling at invasive microdomains in cancer cells

(2011) Begoña Díaz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

(2011) A. R. Grassian et al.   GENES & DEVELOPMENT

Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth

(2011) Ellen Van Obberghen-Schilling et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Fibronectin splice variants: Understanding their multiple roles in health and disease using engineered mouse models

(2011) Eric S. White et al.   IUBMB LIFE

Vicinal thiols are required for activation of the αIIbβ3 platelet integrin

(2011) N. MANICKAM et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

(2011) Jeffrey L. Barnes et al.   KIDNEY INTERNATIONAL

Extracellular Matrix Proteins in Hemostasis and Thrombosis

(2011) W. Bergmeier et al.   Cold Spring Harbor Perspectives in Biology

Labile disulfide bonds are common at the leucocyte cell surface

(2011) C. Metcalfe et al.   Open Biology

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

Does Cellular Hydrogen Peroxide Diffuse or Act Locally?

(2010) Natalia M. Mishina et al.   ANTIOXIDANTS & REDOX SIGNALING

Dissociation of the α-Subunit Calf-2 Domain and the β-Subunit I-EGF4 Domain in Integrin Activation and Signaling

(2010) Wei Wang et al.   BIOCHEMISTRY

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Basement membranes in development and disease

(2010) Fenny Wiradjaja et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Stimulation of Reactive Oxygen Species and Collagen Synthesis by Angiotensin II in Cardiac Fibroblasts

(2010) Paul J. Lijnen et al.   Cardiovascular Therapeutics

Regulation of matrix metalloproteinase activity in health and disease

(2010) Elin Hadler-Olsen et al.   FEBS Journal

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans

(2010) Renato V. Iozzo et al.   FEBS Journal

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Effects of Limiting Extension at the αIIb Genu on Ligand Binding to Integrin αIIbβ3

(2010) Robert Blue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Requirements for Activation in αIIbβ3 Integrin

(2010) Tetsuji Kamata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibulin-5 Is Up-regulated by Hypoxia in Endothelial Cells through a Hypoxia-inducible Factor-1 (HIF-1α)-dependent Mechanism

(2010) Anna Guadall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advances in imaging cell-matrix adhesions

(2010) D. C. Worth et al.   JOURNAL OF CELL SCIENCE

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase

(2010) Jaya Dasgupta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NMR analysis of the  IIb 3 cytoplasmic interaction suggests a mechanism for integrin regulation

(2010) D. G. Metcalf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox-control of matrix metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease

(2010) Supriya Kar et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The Human NADPH Oxidase: Primary and Secondary Defects Impairing the Respiratory Burst Function and the Microbicidal Ability of Phagocytes

(2010) E. B. de Oliveira-Junior et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Tissue elasticity and the ageing elastic fibre

(2009) Michael J. Sherratt   AGE

Receptor Activation of NADPH Oxidases

(2009) Andreas Petry et al.   ANTIOXIDANTS & REDOX SIGNALING

Suprastructures of extracellular matrices: paradigms of functions controlled by aggregates rather than molecules

(2009) Peter Bruckner   CELL AND TISSUE RESEARCH

Extracellular matrix genes as hypoxia-inducible targets

(2009) Johanna Myllyharju et al.   CELL AND TISSUE RESEARCH

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Developmental and Pathogenic Mechanisms of Basement Membrane Assembly

(2009) Peter Yurchenco et al.   CURRENT PHARMACEUTICAL DESIGN

Structure of an integrin with an αI domain, complement receptor type 4

(2009) Can Xie et al.   EMBO JOURNAL

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

(2009) Jian-Ping Xiong et al.   JOURNAL OF CELL BIOLOGY

NAD(P)H Oxidase Mediates TGF- 1-Induced Activation of Kidney Myofibroblasts

(2009) C. D. Bondi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

A Sulfilimine Bond Identified in Collagen IV

(2009) R. Vanacore et al.   SCIENCE

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

(2009) B. Diaz et al.   Science Signaling

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

(2008) Johanna Myllyharju   ANNALS OF MEDICINE

UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin  IIb 3

(2008) R. Verhaar et al.   BLOOD

Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells

(2008) D. Meng et al.   CARDIOVASCULAR RESEARCH

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Discovering mechanisms of signaling-mediated cysteine oxidation

(2008) Leslie B Poole et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations

(2008) E SCHRODER et al.   CURRENT OPINION IN PHARMACOLOGY

Interaction and functional association of protein disulfide isomerase with αVβ3 integrin on endothelial cells

(2008) Maria Swiatkowska et al.   FEBS Journal

Nox4 NAD(P)H Oxidase Mediates Src-dependent Tyrosine Phosphorylation of PDK-1 in Response to Angiotensin II

(2008) Karen Block et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Cysteines in β3 Are Involved in Disulfide Bond Exchange-dependent and -independent Activation of αIIbβ3

(2008) Ronit Mor-Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new redox-dependent mechanism of MMP-1 activity control comprising reduced low-molecular-weight thiols and oxidizing radicals

(2008) Sabine Koch et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mammalian collagen IV

(2008) Jamshid Khoshnoodi et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Glutathione regulates integrin αIIbβ3-mediated cell adhesion under flow conditions

(2008) Chalmette Ball et al.   THROMBOSIS AND HAEMOSTASIS

Breaching the basement membrane: who, when and how?

(2008) R. Grant Rowe et al.   TRENDS IN CELL BIOLOGY

The C-terminus of the γ2 chain but not of the β3 chain of laminin-332 is indirectly but indispensably necessary for integrin-mediated cell reactions

(2007) Alexei Navdaev et al.   EXPERIMENTAL CELL RESEARCH