Cytokines in the Progression of Pancreaticβ-Cell Dysfunction

Targeted Disruption of Pancreatic-Derived Factor (PANDER, FAM3B) Impairs Pancreatic  -Cell Function

(2010) C. E. Robert-Cooperman et al.   DIABETES

Plasma concentration of visfatin is a new surrogate marker of systemic inflammation in type 2 diabetic patients

(2010) Young Sun Kang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling

(2010) Sarah L. Gray et al.   ENDOCRINOLOGY

Lack of direct insulin-like action of visfatin/Nampt/PBEF1 in human adipocytes

(2010) E. Wanecq et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Central infusion of leptin improves insulin resistance and suppresses β-cell function, but not β-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model

(2010) Sunmin Park et al.   LIFE SCIENCES

Characterization of the expression, localization, and secretion of PANDER in α-cells

(2010) Jason R. Carnegie et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Leucine metabolism in regulation of insulin secretion from pancreatic beta cells

(2010) Jichun Yang et al.   NUTRITION REVIEWS

Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin

(2010) James E.P. Brown et al.   PEPTIDES

Cytokine production by islets in health and diabetes: cellular origin, regulation and function

(2010) Marc Y. Donath et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Plasma adiponectin levels are related to obesity, inflammation, blood lipids and insulin in type 2 diabetic and non-diabetic Trinidadians

(2010) B. Shivananda Nayak et al.   Primary Care Diabetes

Leptin: a pivotal regulator of human energy homeostasis

(2009) I Sadaf Farooqi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

Declining  -Cell Compensation for Insulin Resistance in Hispanic Women With Recent Gestational Diabetes Mellitus: Association with changes in weight, adiponectin, and C-reactive protein

(2009) A. H. Xiang et al.   DIABETES CARE

Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic β-cell function

(2009) Wing-Yee So et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia

(2009) R. Retnakaran et al.   DIABETOLOGIA

Regulation of Adiponectin Receptor 2 Expression via PPAR-α in NIT-1 Cells

(2009) Tae Woo JUNG et al.   ENDOCRINE JOURNAL

PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells

(2009) Jichun Yang et al.   FEBS LETTERS

Adipocyte-specific Expression of Murine Resistin Is Mediated by Synergism between Peroxisome Proliferator-activated Receptor γ and CCAAT/Enhancer-binding Proteins

(2009) Takuya Tomaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Study of the proinflammatory role of human differentiated omental adipocytes

(2009) Judit Bassols et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic β-cells

(2009) James E P Brown et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

IL-1β caused pancreatic β-cells apoptosis is mediated in part by endoplasmic reticulum stress via the induction of endoplasmic reticulum Ca2+ release through the c-Jun N-terminal kinase pathway

(2009) Q. Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Leptin Deficiency and Beta-Cell Dysfunction Underlie Type 2 Diabetes in Compound Akt Knockout Mice

(2009) W. S. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Islet Endothelial Activation and Oxidative Stress Gene Expression Is Reduced by IL-1Ra Treatment in the Type 2 Diabetic GK Rat

(2009) Grégory Lacraz et al.   PLoS One

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin Reduces Glucotoxicity-Induced Apoptosis of INS-1 Rat Insulin-Secreting Cells on a Microfluidic Chip

(2009) Peng Lin et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

PDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter

(2008) B BURKHARDT et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Role of PPARγ in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential: Figure 1

(2008) Jichun Yang et al.   CLINICAL SCIENCE

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

(2008) O. Osborn et al.   CYTOKINE

Adiponectin: An update

(2008) M. Guerre-Millo   DIABETES & METABOLISM

Insulin Stimulates Interleukin-6 Expression and Release in LS14 Human Adipocytes through Multiple Signaling Pathways

(2008) Christopher R. LaPensee et al.   ENDOCRINOLOGY

The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia

(2008) Nadine S. Sauter et al.   ENDOCRINOLOGY

Glucose and leptin induce apoptosis in human β-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

(2008) Kathrin Maedler et al.   FASEB JOURNAL

Intensive Glycemic Control Lowers Plasma Visfatin Levels in Patients with Type 2 Diabetes

(2008) J. Zhu et al.   HORMONE AND METABOLIC RESEARCH

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adiponectin Receptor-1 Expression Is Decreased in the Pancreas of Obese Mice

(2008) Terence E. Wade et al.   JOURNAL OF SURGICAL RESEARCH

Guggulsterone, a plant sterol, inhibits NF-κB activation and protects pancreatic β cells from cytokine toxicity

(2008) Na Lv et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Resistin induces rat insulinoma cell RINm5F apoptosis

(2008) Chun-lin Gao et al.   MOLECULAR BIOLOGY REPORTS

Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway

(2008) Mi-Young Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus

(2008) Marc Y Donath et al.   Nature clinical practice. Endocrinology & metabolism

Mechanisms of Glucose-Induced Expression of Pancreatic-Derived Factor in Pancreatic β-Cells

(2007) Oumei Wang et al.   ENDOCRINOLOGY