Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism

The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

(2021) Thuy Van Lam van et al.   ACS Medicinal Chemistry Letters

OFF-State-Specific Inhibition of the Proprotein Convertase Furin

(2021) Sven O. Dahms et al.   ACS Chemical Biology

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases

(2019) Gonzalo Izaguirre   Viruses-Basel

MALDI-TOF Mass Spectrometry-Based High-Throughput Screening for Inhibitors of the Cytosolic DNA Sensor cGAS

(2019) Roman P. Simon et al.   SLAS Discovery

X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket

(2018) Sven O. Dahms et al.   BIOCHEMISTRY

Establishing MALDI-TOF as Versatile Drug Discovery Readout to Dissect the PTP1B Enzymatic Reaction

(2018) Martin Winter et al.   SLAS Discovery

Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry–Based Screening for Drug Discovery

(2018) Martin Winter et al.   SLAS Technology

Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure

(2016) Gisela Schnapp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

(2016) Sven O. Dahms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Furin Inhibitors with Potent Anti-infectious Activity

(2015) Kornelia Hardes et al.   ChemMedChem

X-ray Structures of Human Furin in Complex with Competitive Inhibitors

(2014) Sven O. Dahms et al.   ACS Chemical Biology

Novel microscale approaches for easy, rapid determination of protein stability in academic and commercial settings

(2014) Crispin G. Alexander et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Proprotein Convertases in Health and Disease

(2011) Andrew W. Artenstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

New furin inhibitors based on weakly basic amidinohydrazones

(2010) Frank Sielaff et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development and characterisation of an assay for furin activity

(2010) Gemma L. Bourne et al.   JOURNAL OF IMMUNOLOGICAL METHODS