The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Respiratory syncytial virus entry and how to block it

(2019) Michael B. Battles et al.   NATURE REVIEWS MICROBIOLOGY

Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin

(2019) Thuy Van Lam van et al.   ChemMedChem

A novel cell‐based sensor detecting the activity of individual basic proprotein convertases

(2019) Karin Löw et al.   FEBS Journal

X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket

(2018) Sven O. Dahms et al.   BIOCHEMISTRY

State of the Art in Respiratory Syncytial Virus Drug Discovery and Development

(2018) G. Stuart Cockerill et al.   JOURNAL OF MEDICINAL CHEMISTRY

Entry, Replication, Immune Evasion, and Neurotoxicity of Synthetically Engineered Bat-Borne Mumps Virus

(2018) Nadine Krüger et al.   Cell Reports

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

(2017) Jenny Kouretova et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel Insights into Structure-Activity Relationships of N-Terminally Modified PACE4 Inhibitors

(2016) Anna Kwiatkowska et al.   ChemMedChem

Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

(2016) Sven O. Dahms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells

(2015) Yinghui Lu et al.   ANTIVIRAL RESEARCH

Novel Furin Inhibitors with Potent Anti-infectious Activity

(2015) Kornelia Hardes et al.   ChemMedChem

Optimization of Furin Inhibitors To Protect against the Activation of Influenza Hemagglutinin H5 and Shiga Toxin

(2013) Hugo Gagnon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

(2012) Gero L. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY