Novel Furin Inhibitors with Potent Anti-infectious Activity

A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness

(2015) Julia M. Coppola et al.   NEOPLASIA

X-ray Structures of Human Furin in Complex with Competitive Inhibitors

(2014) Sven O. Dahms et al.   ACS Chemical Biology

Development of Novel Potent Orally Bioavailable Oseltamivir Derivatives Active against Resistant Influenza A

(2014) Dennis Schade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Summary of bi-shRNAfurin/GM-CSF Augmented Autologous Tumor Cell Immunotherapy (FANG™) in Advanced Cancer of the Liver

(2014) John Nemunaitis et al.   ONCOLOGY

Anthrax lethal and edema toxins in anthrax pathogenesis

(2014) Shihui Liu et al.   TRENDS IN MICROBIOLOGY

Viral envelope glycoprotein processing by proprotein convertases

(2013) Antonella Pasquato et al.   ANTIVIRAL RESEARCH

Optimization of Furin Inhibitors To Protect against the Activation of Influenza Hemagglutinin H5 and Shiga Toxin

(2013) Hugo Gagnon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Studies of a Potent PACE4 Inhibitor

(2013) Anna Kwiatkowska et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Approaches to the Treatment of Systemic Anthrax

(2012) A. W. Artenstein et al.   CLINICAL INFECTIOUS DISEASES

Cell-penetrating peptides: classes, origin, and current landscape

(2012) Francesca Milletti   DRUG DISCOVERY TODAY

Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

(2012) Gero L. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin

(2012) Uwe Mueller et al.   JOURNAL OF SYNCHROTRON RADIATION

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

New substrate analogue furin inhibitors derived from 4-amidinobenzylamide

(2011) Gero L. Becker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer

(2011) Neil Senzer et al.   MOLECULAR THERAPY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites

(2010) Praveen K. Madala et al.   CHEMICAL REVIEWS

Acylation of octaarginine: Implication to the use of intracellular delivery vectors

(2010) Sayaka Katayama et al.   JOURNAL OF CONTROLLED RELEASE

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Raxibacumab

(2010) Sohini Mazumdar   mAbs

Structural basis of substrate specificity in the serine proteases

(2010) John J. Perona et al.   PROTEIN SCIENCE

Inhibition of Furin/Proprotein Convertase-catalyzed Surface and Intracellular Processing by Small Molecules

(2009) Tomoko Komiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics

(2009) Gero L. Becker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition

(2009) Eva Böttcher et al.   VACCINE

Knock-out mouse models of proprotein convertases: unique functions or redundancy?

(2008) John et al.   Frontiers in Bioscience-Landmark

Pathogenesis and immunopathology of systemic and nervous canine distemper

(2008) A. Beineke et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY