CXCL13 in Cancer and Other Diseases: Biological Functions, Clinical Significance, and Therapeutic Opportunities

CXCL13 promotes intestinal tumorigenesis through the activation of epithelial AKT signaling

(2021) Qun Zhao et al.   CANCER LETTERS

CXCL13/CXCR5 axis facilitates endothelial progenitor cell homing and angiogenesis during rheumatoid arthritis progression

(2021) Chun-Hao Tsai et al.   Cell Death & Disease

Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

(2021) Yuanyuan Zhang et al.   CANCER CELL

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Serum CXCL13 levels are associated with lymphoma risk and lymphoma occurrence in primary Sjögren’s syndrome

(2020) Emmanuella Young Traianos et al.   RHEUMATOLOGY INTERNATIONAL

PD-1 regulates CXCR5+ CD4 T cell-mediated proinflammatory functions in non-small cell lung cancer patients

(2020) Weiwei Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TNF-α and IL-10 Control CXCL13 Expression in Human Macrophages

(2020) Nessrine Bellamri et al.   JOURNAL OF IMMUNOLOGY

Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood–brain barrier model

(2020) Carolin J. Curtaz et al.   Fluids and Barriers of the CNS

ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC

(2020) Sangeeta Goswami et al.   Science Translational Medicine

Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer

(2020) Senlin Zhao et al.   Journal of Hematology & Oncology

CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis

(2020) Maria Chiara Trolese et al.   EBioMedicine

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CXCL13/CXCR5 Axis Predicts Poor Prognosis and Promotes Progression Through PI3K/AKT/mTOR Pathway in Clear Cell Renal Cell Carcinoma

(2019) Zaosong Zheng et al.   Frontiers in Oncology

A transcriptionally distinct CXCL13+CD103+CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer

(2019) Hagma H Workel et al.   Cancer Immunology Research

Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma

(2019) Luc-Matthieu Fornecker et al.   Scientific Reports

Type I interferon induces CXCL13 to support ectopic germinal center formation

(2019) Alice E. Denton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL13/CXCR5 signaling contributes to diabetes-induced tactile allodynia via activating pERK, pSTAT3, pAKT pathways and pro-inflammatory cytokines production in the spinal cord of male mice

(2019) Sisi Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

CXCL13 as biomarker for histological involvement in Sjögren’s syndrome

(2019) Serena Colafrancesco et al.   RHEUMATOLOGY

CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond

(2019) Marcelo G. Kazanietz et al.   Frontiers in Endocrinology

Mesenchymal stem cells from bone marrow regulate invasion and drug resistance of multiple myeloma cells by secreting chemokine CXCL13

(2019) Guihua Zhang et al.   Bosnian Journal of Basic Medical Sciences

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

(2019) Motoyoshi Nagai et al.   CELL

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

(2019) Stefan Jordan et al.   CELL

Increased circulating CXCL13 levels in systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis

(2019) Yu-Qing Bao et al.   CLINICAL RHEUMATOLOGY

CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction

(2019) Joji Kusuyama et al.   BIOCHEMICAL JOURNAL

Oral cancer‐associated tertiary lymphoid structures: gene expression profile and prognostic value

(2019) K. Li et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1

(2019) Crescenzo D’Alterio et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CXCL13-mediated recruitment of intrahepatic CXCR5+CD8+ T cells favors viral control in chronic HBV infection

(2019) Yongyin Li et al.   JOURNAL OF HEPATOLOGY

Transcriptome Network Analysis Identifies CXCL13-CXCR5 Signaling Modules in the Prostate Tumor Immune Microenvironment

(2019) Adaugo Q. Ohandjo et al.   Scientific Reports

Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor

(2019) Bao-Hua Li et al.   MOLECULAR IMMUNOLOGY

Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development

(2019) Emiel P. C. van der Vorst et al.   THROMBOSIS AND HAEMOSTASIS

CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer

(2019) Guolin Zhang et al.   Cancer Research and Treatment

Interleukin-30/IL27p28 Shapes Prostate Cancer Stem-like Cell Behavior and Is Critical for Tumor Onset and Metastasization

(2018) Carlo Sorrentino et al.   CANCER RESEARCH

Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer

(2018) Si-si Wang et al.   Cellular & Molecular Immunology

Diagnostic value of cerebrospinal fluid CXCL13 for acute Lyme neuroborreliosis. A systematic review and meta-analysis

(2018) T.A. Rupprecht et al.   CLINICAL MICROBIOLOGY AND INFECTION

T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate

(2018) Wataru Ise et al.   IMMUNITY

The prevalence and function of CD4 + CXCR5 + Foxp3 + follicular regulatory T cells in diffuse large B cell lymphoma

(2018) Zhanshan Cha et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer

(2018) Licheng Xu et al.   Oncology Letters

Distribution of circulating follicular helper T cells and expression of interleukin‑21 and chemokine C‑X‑C ligand 13 in gastric cancer

(2018) Xinying Meng et al.   Oncology Letters

A Novel Role for C5a in B-1 Cell Homeostasis

(2018) Katharina Bröker et al.   Frontiers in Immunology

CXCR5 overexpression in HL-60 cells enhances chemotaxis toward CXCL13 without anticipated interaction partners or enhanced MAPK signaling

(2018) Robert J. MacDonald et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

RelA driven co-expression of CXCL13 and CXCR5 is governed by a multifaceted transcriptional program regulating breast cancer progression

(2018) Subir Biswas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Circulating CXCR5+CD4+ T cells assist in the survival and growth of primary diffuse large B cell lymphoma cells through interleukin 10 pathway

(2017) Zhanshan Cha et al.   EXPERIMENTAL CELL RESEARCH

Aberrant Humoral Immune Responses in Neurosyphilis: CXCL13/CXCR5 Play a Pivotal Role for B-Cell Recruitment to the Cerebrospinal Fluid

(2017) Qian Yu et al.   JOURNAL OF INFECTIOUS DISEASES

Ectopic lymphoid neogenesis in rheumatic autoimmune diseases

(2017) Michele Bombardieri et al.   Nature Reviews Rheumatology

Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice

(2017) Hu Huang et al.   PLoS One

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

CXCL13 is androgen-responsive and involved in androgen induced prostate cancer cell migration and invasion

(2017) Long Fan et al.   Oncotarget

Pneumocystis -Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity

(2017) Taylor Eddens et al.   Cell Reports

Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway

(2017) Rachana Garg et al.   Cell Reports

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival

(2017) Vanessa Stache et al.   OncoImmunology

Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer

(2017) Xiaowei Chen et al.   OncoImmunology

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

(2016) S. H. Swerdlow et al.   BLOOD

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5

(2016) Bao-Chun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: LL-37–Mediated Formyl Peptide Receptor-2 Signaling in Follicular Dendritic Cells Contributes to B Cell Activation in Peyer’s Patch Germinal Centers

(2016) Sae-Hae Kim et al.   JOURNAL OF IMMUNOLOGY

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

(2016) Ran He et al.   NATURE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

CXCL13 is a plasma biomarker of germinal center activity

(2016) Colin Havenar-Daughton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomics of human fatty liver disease reveal mechanistically linked lipid droplet–associated gene regulations in bland steatosis and nonalcoholic steatohepatitis

(2016) Nishika Sahini et al.   Translational Research

MDC and BLC are independently associated with the significant risk of early stage lung adenocarcinoma

(2016) Yanwei Zhang et al.   Oncotarget

CXCL13 Promotes Proliferation of Mesangial Cells by Combination with CXCR5 in SLE

(2016) Zhanyun Da et al.   Journal of Immunology Research

The Expression and Significance of CXCR5 and MMP-13 in Colorectal Cancer

(2015) Qin Yan et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The serum CXCL13 level is associated with the Glasgow Prognostic Score in extranodal NK/T-cell lymphoma patients

(2015) Seok Jin Kim et al.   Journal of Hematology & Oncology

The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer

(2015) Lujia Chen et al.   Journal of Translational Medicine

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

(2015) Y. Pylayeva-Gupta et al.   Cancer Discovery

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

(2015) K. E. Lee et al.   Cancer Discovery

CD40 controls CXCR5-induced recruitment of myeloid-derived suppressor cells to gastric cancer

(2015) Yixin Ding et al.   Oncotarget

p53-dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cells

(2015) Nikita A. Mitkin et al.   Scientific Reports

The Effect of C-X-C Motif Chemokine 13 on Hepatocellular Carcinoma Associates with Wnt Signaling

(2015) Chunyan Li et al.   Biomed Research International

The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

(2015) Gui-Zhen Wang et al.   eLife

CXCL13 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Inhibiting miR-23a Expression

(2015) Feng Tian et al.   Stem Cells International

IRF5 is a novel regulator of CXCL13 expression in breast cancer that regulates CXCR5+ B- and T-cell trafficking to tumor-conditioned media

(2014) Erica Maria Pimenta et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression and clinical significance of CXCR5/CXCL13 in human non-small cell lung carcinoma

(2014) RAJESH SINGH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway

(2014) Zhenyu Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection

(2014) K Yamamoto et al.   Mucosal Immunology

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

(2014) M. Ammirante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation

(2014) K. Heinig et al.   Cancer Discovery

Role of CXCL13 in Cigarette Smoke–induced Lymphoid Follicle Formation and Chronic Obstructive Pulmonary Disease

(2013) Ken R. Bracke et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma

(2013) J. L. Rubenstein et al.   BLOOD

A prospective study of 67 serum immune and inflammation markers and risk of non-Hodgkin lymphoma

(2013) M. P. Purdue et al.   BLOOD

CXCL13–CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis

(2013) Subir Biswas et al.   BREAST CANCER RESEARCH AND TREATMENT

CXCR5 polymorphisms in non-Hodgkin lymphoma risk and prognosis

(2013) Bridget Charbonneau et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Nuclear Raf-1 kinase regulates theCXCR5promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation

(2013) Wendy M. Geil et al.   FEBS Journal

An IKK -E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence

(2013) M. Ammirante et al.   GENES & DEVELOPMENT

CD4+ follicular helper T cell infiltration predicts breast cancer survival

(2013) Chunyan Gu-Trantien et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating Inflammation Markers and Prospective Risk for Lung Cancer

(2013) Meredith S. Shiels et al.   JNCI-Journal of the National Cancer Institute

Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5

(2013) Christelle P El-Haibi et al.   Molecular Cancer

The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies

(2013) Jan A. Burger et al.   SEMINARS IN CANCER BIOLOGY

How the microenvironment wires the natural history of chronic lymphocytic leukemia

(2013) Federico Caligaris-Cappio et al.   SEMINARS IN CANCER BIOLOGY

Lung Tumor Microenvironment Induces Specific Gene Expression Signature in Intratumoral NK Cells

(2013) Mélanie Gillard-Bocquet et al.   Frontiers in Immunology

Serum Levels of the Chemokine CXCL13, Genetic Variation in CXCL13 and Its Receptor CXCR5, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk

(2012) S. K. Hussain et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells

(2012) Kathy W.K. Tse et al.   CELLULAR IMMUNOLOGY

Improved Outcome of High-Risk Early HER2 Positive Breast Cancer With High CXCL13-CXCR5 Messenger RNA Expression

(2012) Evangelia Razis et al.   Clinical Breast Cancer

EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5

(2012) Rubén Barroso et al.   FASEB JOURNAL

Mesenchymal stromal cells protect mantle cell lymphoma cells from spontaneous and drug-induced apoptosis through secretion of B-cell activating factor and activation of the canonical and non-canonical nuclear factor  B pathways

(2012) D. J. Medina et al.   HAEMATOLOGICA

Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells

(2012) Beatriz León et al.   NATURE IMMUNOLOGY

CXCL13 activation of c-Myc induces RANK ligand expression in stromal/preosteoblast cells in the oral squamous cell carcinoma tumor–bone microenvironment

(2012) Y Sambandam et al.   ONCOGENE

Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma

(2012) DP Widney et al.   Infectious Agents and Cancer

CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics

(2011) J. Saez de Guinoa et al.   BLOOD

Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

(2011) L. de Chaisemartin et al.   CANCER RESEARCH

CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation

(2011) C. P. El-Haibi et al.   CELL PROLIFERATION

C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway

(2011) LINGYUN ZHANG et al.   Oncology Letters

Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia

(2010) Yu-Ming Shiao et al.   JOURNAL OF NEUROIMMUNOLOGY

The Role of Inflammation in the Pathogenesis of Non-small Cell Lung Cancer

(2010) Dermot S. O'Callaghan et al.   Journal of Thoracic Oncology

PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells

(2010) Christelle P El Haibi et al.   Molecular Cancer

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

Chemokines and chemokine receptors: new insights into cancer-related inflammation

(2010) Gwendal Lazennec et al.   TRENDS IN MOLECULAR MEDICINE

Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting

(2009) Antonina V. Kurtova et al.   BLOOD

Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion

(2009) Shailesh Singh et al.   CANCER LETTERS

Role of CXC chemokine ligand 13 in oral squamous cell carcinoma associated osteolysis in athymic mice

(2009) Subramanya N.M. Pandruvada et al.   INTERNATIONAL JOURNAL OF CANCER

Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines

(2009) Shailesh Singh et al.   INTERNATIONAL JOURNAL OF CANCER

A Novel Function of CXCL13 to Stimulate RANK Ligand Expression in Oral Squamous Cell Carcinoma Cells

(2009) S. Yuvaraj et al.   MOLECULAR CANCER RESEARCH

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

(2009) Adam J Bass et al.   NATURE GENETICS

Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients

(2008) J Panse et al.   BRITISH JOURNAL OF CANCER

Helicobacter pylori and Antrum Erosion-Specific Gene Expression Patterns: The Discriminative Role of CXCL13 and VCAM1 Transcripts

(2008) Orsolya Galamb et al.   HELICOBACTER