Article
Clinical Neurology
Aurelian Ungureanu, Magali Le Garff-Tavernier, Myrto Costopoulos, Timothee Parratte, Abdelmalek Brinet, Helene Durand, Claude Gaultier, Remy Hurstel, Isabelle Alamome, Francois Sellal, Guido Ahle
Summary: The study indicates that CSF IL-6 levels could serve as a useful biomarker in the differential diagnosis of CNSID and suspected PCNSL, in addition to CSF IL-10.
JOURNAL OF NEUROLOGY
(2021)
Article
Hematology
Andres J. M. Ferreri, Teresa Calimeri, Paolo Lopedote, Ilaria Francaviglia, Rita Daverio, Chiara Iacona, Cristina Belloni, Sara Steffanoni, Alessandro Gulino, Elena Anghileri, Angelo Diffidenti, Annamaria Finardi, Filippo Gagliardi, Nicoletta Anzalone, Alessandro Nonis, Roberto Furlan, Daniela De Lorenzo, Maria R. Terreni, Vittorio Martinelli, Marianna Sassone, Marco Foppoli, Piera Angelillo, Elena Guggiari, Andrea Falini, Pietro Mortini, Massimo Filippi, Vittoria Tarantino, Marica Eoli, Fabio Ciceri, Claudio Doglioni, Claudio Tripodo, Massimo Locatelli, Maria Giulia Cangi, Maurilio Ponzoni
Summary: This study found that high levels of mut-MYD88 and IL-10 in the CSF of patients with PCNSL reflect the MYD88 mutational status and expression of this IL in PCNSL tissue, showing very high sensitivity and specificity for detecting PCNSL at initial diagnosis and relapse. These biomarkers could have implications for patients with lesions unsuitable for biopsy.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Medical Laboratory Technology
Kun Chen, Xiangyu Li, Di Wang, Yanchun Ma, Bobin Chen, Qingping Wang, Jingjing Ma, Ming Guan
Summary: Aqueous humor can serve as a potential sample type for the diagnosis of intraocular lymphoma when detecting IL-6 and IL-10, showing higher diagnostic value and lower operating risk compared to vitreous specimens.
CLINICA CHIMICA ACTA
(2021)
Article
Cell Biology
Kristina-Ana Klaric, Nazia Riaz, Karama Asleh, Xiu Qing Wang, Tadros Atalla, Sarah Strickland, Torsten O. Nielsen, Zuzana Kos
Summary: The study found that SOX10 is a moderately sensitive but highly specific immunohistochemical biomarker for the basal-like intrinsic subtype of breast cancer, independent of hormone receptor status, outperforming other tested basal markers.
Article
Hematology
M. K. Gandhi, T. Hoang, S. C. Law, S. Brosda, K. O'Rourke, J. W. D. Tobin, F. Vari, V Murigneux, L. Fink, J. Gunawardana, C. Gould, H. Oey, K. Bednarska, S. Delecluse, R. U. Trappe, L. Merida de Long, M. B. Sabdia, G. Bhagat, G. Hapgood, E. Blyth, L. Clancy, J. Wight, E. Hawkes, L. M. Rimsza, A. Maguire, K. Bojarczuk, B. Chapuy, C. Keane
Summary: Primary central nervous system lymphoma (PCNSL) is a rare brain lymphoma that has distinct immunobiological differences between EBV-associated PCNSL in immunosuppressed individuals and EBV-negative PCNSL. These differences are evident in cellular mutations and immune environments.
Article
Cell Biology
Nir Yogev, Tanja Bedke, Yasushi Kobayashi, Leonie Brockmann, Dominika Lukas, Tommy Regen, Andrew L. Croxford, Alexei Nikolav, Nadine Hovelmeyer, Esther von Stebut, Marco Prinz, Carles Ubeda, Kevin J. Maloy, Nicola Gagliani, Richard A. Flavell, Ari Waisman, Samuel Huber
Summary: Interleukin (IL)-10 is a prototypical anti-inflammatory cytokine that plays a role in immune homeostasis. In CNS inflammation, T-cell-derived IL-10 can promote inflammation and enhance autoimmunity.
Review
Oncology
Clemens Seidel, Christine Viehweger, Rolf-Dieter Kortmann
Summary: Current evidence suggests that radiotherapy has a role in the treatment of PCNSL patients, especially for those who are not suitable for ASCT. Consolidating reduced dose WBRT after complete remission is a feasible option, while further research is needed for local stereotactic radiotherapy for residual disease.
Article
Clinical Neurology
Anastasia Geladaris, Silke Haeusser-Kinzel, Roxanne Pretzsch, Nitzan Nissimov, Klaus Lehmann-Horn, Darius Haeusler, Martin S. Weber
Summary: B cells contribute to chronic inflammatory conditions, but removal of B cells may enhance the activity of monocytes. B cell-provided interleukin-10 (IL-10) plays a key role in controlling the pro-inflammatory activity of peripheral myeloid cells and microglia. Depleting B cells in a mouse model of multiple sclerosis (MS) accelerates disease severity, while adoptive transfer of IL-10-providing B cells reverses clinical exacerbation.
ACTA NEUROPATHOLOGICA
(2023)
Article
Oncology
Clement Desjardins, Delphine Larrieu-Ciron, Sylvain Choquet, Karima Mokhtari, Frederic Charlotte, Lucia Nichelli, Bertrand Mathon, Guido Ahle, Magali Le Garff-Tavernier, Andrea Morales-Martinez, Caroline Dehais, Khe Hoang-Xuan, Caroline Houillier
Summary: This study retrospectively selected 11 patients with primary CNS MALT lymphoma and found that chemotherapy is an effective treatment with excellent long-term outcome and absence of neurotoxicity.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Qing Li, Yan Ma, Zhiguang Lin, Jingjing Ma, Hui Kang, Mengxue Zhang, Huiwen Xu, Bobin Chen
Summary: This study evaluated the efficacy and adverse effects of HD-MTX plus IDA compared to HD-MTX monotherapy in newly diagnosed immunocompetent PCNSL patients. The results showed no significant difference in response rates and progression-free survival between the two treatment groups. The combination therapy did not offer any therapeutic advantage over HD-MTX monotherapy.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yilin Liu, Li Zhan, Zhenpeng Qin, James Sackrison, John C. Bischof
Summary: LFAs, paper-based point-of-care diagnostic tools, have traditionally lower sensitivities and specificities than standard laboratory tests. Recent efforts have focused on optimizing assay kinetics, signal amplification, and sample preamplification to increase sensitivities, as well as improving specificity through high-affinity molecules and assay optimization. With continuing improvements, LFAs may soon offer performance competitive with laboratory techniques while retaining a rapid format.
Article
Clinical Neurology
Joakim Wismann, Rune Horlykke Sommer-Sorensen, Mikkel Seremet Kofoed, Bo Halle, Christian Bonde Pedersen, Mette Katrine Schulz, Mads Hjortdal Gronhoj, Thomas Stauffer Larsen, Michael Boe Moller, Frantz Rom Poulsen
Summary: This study evaluated the management and outcome of PCNSL patients diagnosed by biopsy, finding that age, performance score at diagnosis, and treatment modality were important factors affecting overall survival.
ACTA NEUROCHIRURGICA
(2022)
Article
Engineering, Environmental
Ting Liu, Xi Zhang, Lizhen He, Zehang Zhang, Yuhan Sun, Junmei Feng, Zhiming Lin, Tianfeng Chen
Summary: This study developed a selenium nanosystem with surface decoration of calf thymus DNA to specifically recognize and remove anti-dsDNA autoantibodies in SLE patients. The nanotherapeutics showed excellent biocompatibility and safety, and had higher clearance ratio compared to other clinical products. Furthermore, the nanotherapeutics could visualize the distribution of anti-dsDNA antibodies in kidney lesions and semi-quantify the antibody deposition.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Li Fan, Chaoying Tong, Yuanxin Cao, Ruiqing Long, Qisheng Wei, Fang Wang, Xia Tong, Shuyun Shi, Ying Guo
Summary: This paper presents a novel esterase-activatable aggregation-induced emission (AIE) plus excited-state intramolecular proton transfer (ESIPT) probe for the ratiometric sensing of carbaryl. The strategy demonstrated high selectivity and reliability with a low limit of detection, making it a facile, sensitive, and accurate method for the detection of carbaryl in real complex samples.
Article
Cell Biology
Wen-Xing Li, Shao-Xing Dai, San-Qi An, Tingting Sun, Justin Liu, Jun Wang, Leyna G. Liu, Yang Xun, Hua Yang, Li-Xia Fan, Xiao-Li Zhang, Wan-Qin Liao, Hua You, Luca Tamagnone, Fang Liu, Jing-Fei Huang, Dahai Liu
Summary: This study identified transcriptome differences between HL, DLBCL, and MCL by screening lymphoma marker genes and constructed lymphoma-specific diagnostic models. The optimal diagnostic models for HL, DLBCL, and MCL contain specific marker genes with high AUC values, which may be helpful for clinical diagnosis and prognosis when combined with other clinical markers.
Article
Clinical Neurology
R. F. Barajas, G. Rufener, J. Starkey, T. Duncan, C. Fuss
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Article
Oncology
Ramon F. Barajas, Letterio S. Politi, Nicoletta Anzalone, Heiko Schoder, Christopher P. Fox, Jerrold L. Boxerman, Timothy J. Kaufmann, C. Chad Quarles, Benjamin M. Ellingson, Dorothee Auer, Ovidiu C. Andronesi, Andres J. M. Ferreri, Maciej M. Mrugala, Christian Grommes, Edward A. Neuwelt, Prakash Ambady, James L. Rubenstein, Gerald Illerhaus, Motoo Nagane, Tracy T. Batchelor, Leland S. Hu
Summary: The article discusses the molecular and pathophysiologic characteristics of PCNSL, as well as critically reviewing the use of PET and MRI in diagnosis and treatment of PCNSL. Recommendations on standardized imaging practices are provided, along with ideal and minimum standard protocols for 3T and 1.5T MR systems to facilitate widespread adoption.
Article
Clinical Neurology
Zachary D. Threlkeld, Brian J. Scott
NEUROLOGIC CLINICS
(2021)
Article
Clinical Neurology
Carl A. Gold, Brian J. Scott, Yingjie Weng, Eric Bernier, Kathryn A. Kvam
Summary: This study aims to evaluate the impact of an academic neurohospitalist service on clinical outcomes. The results showed that implementing a neurohospitalist service was associated with a significant increase in patient complexity and acuity, and a trend towards reduced readmissions.
Article
Clinical Neurology
Ramon F. Barajas, Prakash Ambady, Jeanne Link, Kenneth A. Krohn, Ahmed Raslan, Nadine Mallak, Randy Woltjer, Leslie Muldoon, Edward A. Neuwelt
Summary: This study aimed to explore the role of [F-18]-fluoromisonidazole (FMISO) positron emission tomography (PET) in response assessment after immunotherapy in glioblastoma. By conducting FMISO PET and Gd-MRI evaluations on six patients, it was found that hypoxic fraction might serve as a biologically specific metric for identifying immunotherapeutic failure.
NEURO-ONCOLOGY PRACTICE
(2022)
Article
Clinical Neurology
David S. Rogawski, Jeffrey J. Nirschl, Jamie McDonald, Esther Nie, Nicholas U. Schwartz, Hannes Vogel, Brian J. Scott, Carl A. Gold, Lucas B. Kipp
Summary: This study reports a rare case of primary CNS histiocytic sarcoma that presented with clinical and radiological features mimicking neuromyelitis optica spectrum disorder, underscoring the importance of evaluating for infiltrative diseases in atypical cases of seronegative NMOSD.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Sammita Satyanarayan, Jay Spiegel, Dominic Hovsepian, Matthew Markert, Reena Thomas, Lori Muffly, David Miklos, Kevin Graber, Brian J. Scott
Summary: In this study, the incidence of seizures and EEG abnormalities in patients with ICANS receiving axi-cel therapy was characterized. The results showed that 7.1% of the total cohort and 12% of patients with ICANS experienced seizures. Ictal-interictal continuum abnormalities, especially generalized periodic discharges, were also frequently observed in ICANS patients.
Article
Clinical Neurology
David P. Lerner, Aleksey Tadevosyan, Brian J. Scott, Anil Ramineni, Ribal Bassil, Joseph D. Burns, James A. Russell
Summary: The objective of this study was to determine the effect of implementing a standardized DNC/BD checklist in the electronic medical record (EMR) on adherence to institutional policies. The study found that the implementation of the checklist significantly improved adherence to the policies.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Esther H. Nie, Saman S. Ahmadian, Sushma N. Bharadwaj, Lehi Acosta-Alvarez, Zachary D. Threlkeld, Matthew J. Frank, David B. Miklos, Michelle Monje, Brian J. Scott, Hannes Vogel
Summary: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common condition following CAR T therapy and other cancer cell therapies, but its underlying pathophysiology and neuropathology are not fully understood. This study presents the cellular and tissue neuropathologic analysis of a patient with severe ICANS after anti-CD19 CAR T therapy, revealing a pattern of multifocal demyelinating leukoencephalopathy associated with severe ICANS. The loss of region-specific oligodendrocyte lineage cells is proposed as a potential cellular and pathophysiologic factor in severe ICANS. Elucidation of the mechanistic processes underlying ICANS is crucial for minimizing neurotoxicity in CAR T-cell and immunotherapy treatments.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Neuroimaging
Cymon N. Kersch, Leslie L. Muldoon, Cheryl J. Claunch, Rongwei Fu, Daniel Schwartz, Soonmee Cha, Jay Starkey, Edward A. Neuwelt, Ramon F. Barajas Jr
Summary: This study found that gene expression networks related to the immune microenvironment in glioblastoma can be characterized non-invasively using MRI phenotypes, which could be used for patient stratification and treatment evaluation.
NEURORADIOLOGY JOURNAL
(2023)
Article
Medicine, Research & Experimental
Hao Tan, Caleb Nerison, Cooper Stateler, Stephen G. Bowden, Ahmed M. Raslan, Prakash Ambady, Ramon F. Barajas Jr, Matthew D. Wood
Summary: Pathogenic mutations in MLH1, MSH2, PMS2, and MSH6 genes can lead to Lynch syndrome and increase the risk of various types of cancers. In rare cases, germline pathogenic aberrations in these genes can also be associated with the development of primary central nervous system tumors. This case report highlights the importance of genetic profiling in understanding the molecular mechanisms underlying multicentric gliomas and emphasizes the oncogenic potential of germline mismatch repair gene pathogenic alterations within central nervous system gliomas.
COLD SPRING HARBOR MOLECULAR CASE STUDIES
(2023)
Article
Oncology
Jared Stoller, Cymon N. Kersch, Leslie L. Muldoon, Prakash Ambady, Christina A. Harrington, Rongwei Fu, Ahmed M. Raslan, Aclan Dogan, Edward A. Neuwelt, Ramon F. Barajas Jr
Summary: This study demonstrates that Fe and Gd-enhanced MRI phenotypes have the potential to reveal spatially distinct immune processes within glioblastoma. Fe improves upon the standard of care Gd enhancement by specifically localizing glioblastoma-associated inflammatory processes, providing valuable insights into tumor biology.
NEURO-ONCOLOGY ADVANCES
(2023)
Meeting Abstract
Clinical Neurology
Esther Nie, Saman Ahmadian, Sushma Bharadwaj, Lehi Acosta-Alvarez, Zachary Threlkeld, Matthew Frank, David Miklos, Donald Born, Brian Scott, Michelle Monje, Hannes Vogel
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Jeffrey Nirschl, David Rogawski, Jamie McDonald, Esther Nie, Nicholas Schwartz, Brian Scott, Dita Gratzinger, Carl Gold, Lucas Kipp, Hannes Vogel
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Rosyli Reveron-Thornton, Brian J. Scott, David Post, Anna Finley Caulfield, Katherine Werbaneth, Dominic A. Hovsepian, Jay Spiegel, David Miklos, Reena P. Thomas, Chirag B. Patel
Summary: This case illustrates the clinical management challenges of a complex and rare neurotoxic side effect of CAR-T cell therapy, namely nonconvulsive status epilepticus (NCSE) following status epilepticus.